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[The influence of correction of acidosis on plasma level of branched-chain amino acids in chronic hemodialysis patients].
Nihon Jinzo Gakkai Shi. 1998 May; 40(4):258-62.NJ

Abstract

Seven patients undergoing chronic hemodialysis three times a week and whose plasma bicarbonate concentration on predialysis was consistently under 18 mmol/l due to bicarbonate dialysis (BCD), were treated with BCD for 2 weeks, then switched to acetate-free biofiltration (AFB) for 8 weeks. In both periods, the same high flux dialyzer (AN69HF) was used. The treatment time, dialysate flow rate and blood flow rate were kept constant in each patient during both periods. Plasma bicarbonate concentration (HCO3-), serum urea nitrogen (SUN), serum creatinine (Cr) and plasma amino acids concentrations (AA) were measured before dialysis and KT/V was calculated on the 2nd days of the last week in both periods. HCO3- on AFB was significantly higher than that on BCD (16.4 +/- 0.9 vs 19.9 +/- 1.8 mmol/l; p < 0.05). SUN on AFB was significantly lower than that on BCD even though the dialysis schedule and dietary content were not changed (84.7 +/- 3.7 vs 76.6 +/- 3.8 mg/dl; p < 0.05). TP, Cr and KT/V were not significantly different. Plasma total amino acid concentration (TAA) and plasma essential amino acid concentration (EAA) were not significantly different in both periods. In contrast, plasma branched-chain amino acid concentrations (BCAA) on AFB were significantly higher than that on BCD (313.5 +/- 44.3 vs 390.3 +/- 50.7 mumol/l; p < 0.05). Plasma BCAA concentrations, valine (VAL), leucine (LEU) and isoleucine (ILE), were significantly higher on AFB than that on BCD, respectively (p < 0.05). These findings suggest that optimal correction of the metabolic acidosis in chronic hemodialysis patients by AFB leads to a significant increase in plasma BCAA concentration.

Authors+Show Affiliations

2nd Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

9654909

Citation

Kikuchi, F, et al. "[The Influence of Correction of Acidosis On Plasma Level of Branched-chain Amino Acids in Chronic Hemodialysis Patients]." Nihon Jinzo Gakkai Shi, vol. 40, no. 4, 1998, pp. 258-62.
Kikuchi F, Kuno T, Nagura Y, et al. [The influence of correction of acidosis on plasma level of branched-chain amino acids in chronic hemodialysis patients]. Nihon Jinzo Gakkai Shi. 1998;40(4):258-62.
Kikuchi, F., Kuno, T., Nagura, Y., Takahashi, S., & Kanmatsuse, K. (1998). [The influence of correction of acidosis on plasma level of branched-chain amino acids in chronic hemodialysis patients]. Nihon Jinzo Gakkai Shi, 40(4), 258-62.
Kikuchi F, et al. [The Influence of Correction of Acidosis On Plasma Level of Branched-chain Amino Acids in Chronic Hemodialysis Patients]. Nihon Jinzo Gakkai Shi. 1998;40(4):258-62. PubMed PMID: 9654909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The influence of correction of acidosis on plasma level of branched-chain amino acids in chronic hemodialysis patients]. AU - Kikuchi,F, AU - Kuno,T, AU - Nagura,Y, AU - Takahashi,S, AU - Kanmatsuse,K, PY - 1998/7/9/pubmed PY - 1998/7/9/medline PY - 1998/7/9/entrez SP - 258 EP - 62 JF - Nihon Jinzo Gakkai shi JO - Nihon Jinzo Gakkai Shi VL - 40 IS - 4 N2 - Seven patients undergoing chronic hemodialysis three times a week and whose plasma bicarbonate concentration on predialysis was consistently under 18 mmol/l due to bicarbonate dialysis (BCD), were treated with BCD for 2 weeks, then switched to acetate-free biofiltration (AFB) for 8 weeks. In both periods, the same high flux dialyzer (AN69HF) was used. The treatment time, dialysate flow rate and blood flow rate were kept constant in each patient during both periods. Plasma bicarbonate concentration (HCO3-), serum urea nitrogen (SUN), serum creatinine (Cr) and plasma amino acids concentrations (AA) were measured before dialysis and KT/V was calculated on the 2nd days of the last week in both periods. HCO3- on AFB was significantly higher than that on BCD (16.4 +/- 0.9 vs 19.9 +/- 1.8 mmol/l; p < 0.05). SUN on AFB was significantly lower than that on BCD even though the dialysis schedule and dietary content were not changed (84.7 +/- 3.7 vs 76.6 +/- 3.8 mg/dl; p < 0.05). TP, Cr and KT/V were not significantly different. Plasma total amino acid concentration (TAA) and plasma essential amino acid concentration (EAA) were not significantly different in both periods. In contrast, plasma branched-chain amino acid concentrations (BCAA) on AFB were significantly higher than that on BCD (313.5 +/- 44.3 vs 390.3 +/- 50.7 mumol/l; p < 0.05). Plasma BCAA concentrations, valine (VAL), leucine (LEU) and isoleucine (ILE), were significantly higher on AFB than that on BCD, respectively (p < 0.05). These findings suggest that optimal correction of the metabolic acidosis in chronic hemodialysis patients by AFB leads to a significant increase in plasma BCAA concentration. SN - 0385-2385 UR - https://www.unboundmedicine.com/medline/citation/9654909/[The_influence_of_correction_of_acidosis_on_plasma_level_of_branched_chain_amino_acids_in_chronic_hemodialysis_patients]_ L2 - https://medlineplus.gov/dialysis.html DB - PRIME DP - Unbound Medicine ER -