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Inwardly rectifying K+ currents in intermediate cells in the cochlea of gerbils: a possible contribution to the endocochlear potential.
Neurosci Lett. 1998 May 15; 247(2-3):175-8.NL

Abstract

The stria vascularis in the cochlea generates the endocochlear potential (EP) and secretes K+-rich endolymph; both are indispensable for normal sound transduction by hair cells. K+ conductance in the intermediate cell, one of the several types of cells constituting the stria vascularis, was investigated by the whole-cell patch-clamp technique. Inwardly-rectifying K+ (Kir) currents were the major currents observed. The currents were inhibited dose-dependently by Ba2+, quinine, verapamil and Cs+, but not by tetraethylammonium (20 mM), 4-aminopyridine (5 mM) or Cd2+ (1 mM). The similarity between the effect of inhibitors on Kir currents and on the EP (Takeuchi et al., Hearing Res., 101 (1996) 181-185) suggests a direct contribution of the Kir conductance to the generation of the EP.

Authors+Show Affiliations

Department of Physiology, Kochi Medical School, Nankoku, Japan. takeuchi@kochi-ms.ac.jpNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9655621

Citation

Takeuchi, S, and M Ando. "Inwardly Rectifying K+ Currents in Intermediate Cells in the Cochlea of Gerbils: a Possible Contribution to the Endocochlear Potential." Neuroscience Letters, vol. 247, no. 2-3, 1998, pp. 175-8.
Takeuchi S, Ando M. Inwardly rectifying K+ currents in intermediate cells in the cochlea of gerbils: a possible contribution to the endocochlear potential. Neurosci Lett. 1998;247(2-3):175-8.
Takeuchi, S., & Ando, M. (1998). Inwardly rectifying K+ currents in intermediate cells in the cochlea of gerbils: a possible contribution to the endocochlear potential. Neuroscience Letters, 247(2-3), 175-8.
Takeuchi S, Ando M. Inwardly Rectifying K+ Currents in Intermediate Cells in the Cochlea of Gerbils: a Possible Contribution to the Endocochlear Potential. Neurosci Lett. 1998 May 15;247(2-3):175-8. PubMed PMID: 9655621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inwardly rectifying K+ currents in intermediate cells in the cochlea of gerbils: a possible contribution to the endocochlear potential. AU - Takeuchi,S, AU - Ando,M, PY - 1998/7/9/pubmed PY - 1998/7/9/medline PY - 1998/7/9/entrez SP - 175 EP - 8 JF - Neuroscience letters JO - Neurosci Lett VL - 247 IS - 2-3 N2 - The stria vascularis in the cochlea generates the endocochlear potential (EP) and secretes K+-rich endolymph; both are indispensable for normal sound transduction by hair cells. K+ conductance in the intermediate cell, one of the several types of cells constituting the stria vascularis, was investigated by the whole-cell patch-clamp technique. Inwardly-rectifying K+ (Kir) currents were the major currents observed. The currents were inhibited dose-dependently by Ba2+, quinine, verapamil and Cs+, but not by tetraethylammonium (20 mM), 4-aminopyridine (5 mM) or Cd2+ (1 mM). The similarity between the effect of inhibitors on Kir currents and on the EP (Takeuchi et al., Hearing Res., 101 (1996) 181-185) suggests a direct contribution of the Kir conductance to the generation of the EP. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/9655621/Inwardly_rectifying_K+_currents_in_intermediate_cells_in_the_cochlea_of_gerbils:_a_possible_contribution_to_the_endocochlear_potential_ L2 - https://medlineplus.gov/potassium.html DB - PRIME DP - Unbound Medicine ER -