Tags

Type your tag names separated by a space and hit enter

[Effects of dietary fat saturation on levels of plasma lipoprotein (a) and lipids].
Med Clin (Barc). 1998 May 16; 110(17):641-5.MC

Abstract

BACKGROUND

Lipoprotein (a) (Lp[a]) is a known risk factor for coronary heart disease. Lp(a) plasma concentration mainly depends on genetic polymorphism. The aim of this study was evaluate the effect of dietary fat saturation on Lp(a) plasma concentration.

SUBJECTS AND METHODS

Forty two subjects (eighteen women and twenty four men) were placed in four consecutive 5 weeks diet periods. Energy intake from proteins, carbohydrates and fats was constant during the study and there were only changes on fatty acids composition. First period was enriched in saturated fatty acids (SFA), second period in monounsaturated fatty acids (MUFA) and third and fourth periods were enriched in polyunsaturated fatty acids (PUFA). Fourth period was also enriched in PUFA n-3 (blue fish).

RESULTS

Changes on dietary fat saturation had a significant effect on plasma lipids and lipoproteins. Lp(a) plasma concentration was minimum in SFA phase (6.8 [SD 7.3] mg/dl), increasing during MUFA phase (8.7 [8.5] mg/dl) and was maximum in PUFA n-6 and PUFA n-3 (11.5 [11.1] and 12.7 [11.9] mg/dl, respectively) (p < 0.0001).

CONCLUSIONS

Changes on dietary fat saturation significantly modify Lp(a) plasma concentration. These variations went in opposite direction to LDL-cholesterol modifications and were clinically irrelevant.

Authors+Show Affiliations

Unidad de Investigación en Lípidos, Fundación Jiménez Díaz, Madrid.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

9656207

Citation

Lahoz, C, et al. "[Effects of Dietary Fat Saturation On Levels of Plasma Lipoprotein (a) and Lipids]." Medicina Clinica, vol. 110, no. 17, 1998, pp. 641-5.
Lahoz C, Alonso R, Porres A, et al. [Effects of dietary fat saturation on levels of plasma lipoprotein (a) and lipids]. Med Clin (Barc). 1998;110(17):641-5.
Lahoz, C., Alonso, R., Porres, A., & Mata, P. (1998). [Effects of dietary fat saturation on levels of plasma lipoprotein (a) and lipids]. Medicina Clinica, 110(17), 641-5.
Lahoz C, et al. [Effects of Dietary Fat Saturation On Levels of Plasma Lipoprotein (a) and Lipids]. Med Clin (Barc). 1998 May 16;110(17):641-5. PubMed PMID: 9656207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of dietary fat saturation on levels of plasma lipoprotein (a) and lipids]. AU - Lahoz,C, AU - Alonso,R, AU - Porres,A, AU - Mata,P, PY - 1998/7/10/pubmed PY - 1998/7/10/medline PY - 1998/7/10/entrez SP - 641 EP - 5 JF - Medicina clinica JO - Med Clin (Barc) VL - 110 IS - 17 N2 - BACKGROUND: Lipoprotein (a) (Lp[a]) is a known risk factor for coronary heart disease. Lp(a) plasma concentration mainly depends on genetic polymorphism. The aim of this study was evaluate the effect of dietary fat saturation on Lp(a) plasma concentration. SUBJECTS AND METHODS: Forty two subjects (eighteen women and twenty four men) were placed in four consecutive 5 weeks diet periods. Energy intake from proteins, carbohydrates and fats was constant during the study and there were only changes on fatty acids composition. First period was enriched in saturated fatty acids (SFA), second period in monounsaturated fatty acids (MUFA) and third and fourth periods were enriched in polyunsaturated fatty acids (PUFA). Fourth period was also enriched in PUFA n-3 (blue fish). RESULTS: Changes on dietary fat saturation had a significant effect on plasma lipids and lipoproteins. Lp(a) plasma concentration was minimum in SFA phase (6.8 [SD 7.3] mg/dl), increasing during MUFA phase (8.7 [8.5] mg/dl) and was maximum in PUFA n-6 and PUFA n-3 (11.5 [11.1] and 12.7 [11.9] mg/dl, respectively) (p < 0.0001). CONCLUSIONS: Changes on dietary fat saturation significantly modify Lp(a) plasma concentration. These variations went in opposite direction to LDL-cholesterol modifications and were clinically irrelevant. SN - 0025-7753 UR - https://www.unboundmedicine.com/medline/citation/9656207/[Effects_of_dietary_fat_saturation_on_levels_of_plasma_lipoprotein__a__and_lipids]_ L2 - http://www.elsevier.es/en/linksolver/ft/ivp/0025-7753/110/641 DB - PRIME DP - Unbound Medicine ER -