TY - JOUR T1 - Duration of effects of dietary fish oil supplementation on serum eicosapentaenoic acid and docosahexaenoic acid concentrations in dogs. AU - Hansen,R A, AU - Ogilvie,G K, AU - Davenport,D J, AU - Gross,K L, AU - Walton,J A, AU - Richardson,K L, AU - Mallinckrodt,C H, AU - Hand,M S, AU - Fettman,M J, PY - 1998/7/11/pubmed PY - 1998/7/11/medline PY - 1998/7/11/entrez SP - 864 EP - 8 JF - American journal of veterinary research JO - Am J Vet Res VL - 59 IS - 7 N2 - OBJECTIVE: To determine how long serum concentrations of omega-3 fatty acids remain elevated after cessation of dietary fish oil supplementation. ANIMALS: 12 healthy Beagles. PROCEDURE: Baseline serum concentrations of linoleic acid, linolenic acid, arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) were measured. Dogs were then fed a diet supplemented with soybean oil or fish oil for 8 weeks, and serum fatty acid concentrations were measured while dogs were fed the experimental diets and for 18 weeks after they were switched to a maintenance diet. RESULTS: For dogs fed the fish oil diet, serum EPA and DHA concentrations were significantly increased by week 1 and remained increased for 7 (DHA concentration) or 3 (EPA concentration) weeks after dietary fish oil supplementation was discontinued. CONCLUSIONS: In dogs, supplementation of the diet with fish oil may have effects for several weeks after dietary supplementation is discontinued. CLINICAL RELEVANCE: Studies of the effects of fish oil supplementation that use a crossover design should allow for an appropriate washout period. SN - 0002-9645 UR - https://www.unboundmedicine.com/medline/citation/9659553/Duration_of_effects_of_dietary_fish_oil_supplementation_on_serum_eicosapentaenoic_acid_and_docosahexaenoic_acid_concentrations_in_dogs_ L2 - https://antibodies.cancer.gov/detail/CPTC-TIMP1-2 DB - PRIME DP - Unbound Medicine ER -