Tags

Type your tag names separated by a space and hit enter

Stability of vancomycin in an extemporaneously compounded ophthalmic solution.
Am J Health Syst Pharm 1998; 55(13):1386-8AJ

Abstract

The stability of vancomycin 31 mg/mL (as the hydrochloride) in an artificial tears solution at -10, 4, 25, and 40 degrees C was studied. Vancomycin power was reconstituted with sterile water for injection to a concentration of 50 mg/mL. Artificial tears solution containing 0.3% hydroxypropyl methylcellulose, 0.1% dextran 70, 0.01% benzalkonium chloride, and 0.05% edetate disodium was used to produce a final concentration of 31 mg/mL. Triplicate solutions for each storage temperature and sampling time were prepared. The solutions were stored at -10, 4, 25, and 40 degrees C. Samples were taken initially and at 3, 7, 10, 21, 30, 45, and 60 days for visual inspection and analysis by high-performance liquid chromatography. All solutions remained clear and colorless at -10, 4, and 25 degrees C throughout the study period. By day 3, crystalline particles formed in the solutions stored at 40 degrees C. No substantial change in pH was observed at any time. At -10 degrees C, the solutions retained more than 90% of their initial vancomycin concentrations throughout the study period. The solutions retained a mean of at least 90% of the initial drug concentration for 21 days at 4 degrees C and for 7 days at 25 degrees C. For the solutions stored at 25 or 40 degrees C, less than 85% of the initial vancomycin concentration remained after 10 and 3 days, respectively. Vancomycin 31 mg/mL (as the hydrochloride) in an artificial tears solution was stable for 45 days at -10 degrees C, 10 days at 4 degrees C, and 7 days at 25 degrees C in the tears solution's original container.

Authors+Show Affiliations

Department of Pharmacy Practice, College of Pharmacy, University of South Carolina, Columbia 29208, USA. fuhrman@phar2.pharm.sc.eduNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9659967

Citation

Fuhrman, L C., and R T. Stroman. "Stability of Vancomycin in an Extemporaneously Compounded Ophthalmic Solution." American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists, vol. 55, no. 13, 1998, pp. 1386-8.
Fuhrman LC, Stroman RT. Stability of vancomycin in an extemporaneously compounded ophthalmic solution. Am J Health Syst Pharm. 1998;55(13):1386-8.
Fuhrman, L. C., & Stroman, R. T. (1998). Stability of vancomycin in an extemporaneously compounded ophthalmic solution. American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists, 55(13), pp. 1386-8.
Fuhrman LC, Stroman RT. Stability of Vancomycin in an Extemporaneously Compounded Ophthalmic Solution. Am J Health Syst Pharm. 1998 Jul 1;55(13):1386-8. PubMed PMID: 9659967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stability of vancomycin in an extemporaneously compounded ophthalmic solution. AU - Fuhrman,L C,Jr AU - Stroman,R T, PY - 1998/7/11/pubmed PY - 2001/3/28/medline PY - 1998/7/11/entrez SP - 1386 EP - 8 JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists JO - Am J Health Syst Pharm VL - 55 IS - 13 N2 - The stability of vancomycin 31 mg/mL (as the hydrochloride) in an artificial tears solution at -10, 4, 25, and 40 degrees C was studied. Vancomycin power was reconstituted with sterile water for injection to a concentration of 50 mg/mL. Artificial tears solution containing 0.3% hydroxypropyl methylcellulose, 0.1% dextran 70, 0.01% benzalkonium chloride, and 0.05% edetate disodium was used to produce a final concentration of 31 mg/mL. Triplicate solutions for each storage temperature and sampling time were prepared. The solutions were stored at -10, 4, 25, and 40 degrees C. Samples were taken initially and at 3, 7, 10, 21, 30, 45, and 60 days for visual inspection and analysis by high-performance liquid chromatography. All solutions remained clear and colorless at -10, 4, and 25 degrees C throughout the study period. By day 3, crystalline particles formed in the solutions stored at 40 degrees C. No substantial change in pH was observed at any time. At -10 degrees C, the solutions retained more than 90% of their initial vancomycin concentrations throughout the study period. The solutions retained a mean of at least 90% of the initial drug concentration for 21 days at 4 degrees C and for 7 days at 25 degrees C. For the solutions stored at 25 or 40 degrees C, less than 85% of the initial vancomycin concentration remained after 10 and 3 days, respectively. Vancomycin 31 mg/mL (as the hydrochloride) in an artificial tears solution was stable for 45 days at -10 degrees C, 10 days at 4 degrees C, and 7 days at 25 degrees C in the tears solution's original container. SN - 1079-2082 UR - https://www.unboundmedicine.com/medline/citation/9659967/Stability_of_vancomycin_in_an_extemporaneously_compounded_ophthalmic_solution_ L2 - https://academic.oup.com/ajhp/article-lookup/doi/10.1093/ajhp/55.13.1386 DB - PRIME DP - Unbound Medicine ER -