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Propofol and methohexital as anesthetic agents for electroconvulsive therapy (ECT): a comparison of seizure-quality measures and vital signs.
J ECT. 1998 Mar; 14(1):28-35.JE

Abstract

In a randomized crossover study, the influence of the anesthetics methohexital and propofol on EEG seizure parameters, seizure-quality measures, vital signs, and oxygen saturation (SpO2) and end-tidal carbon dioxide tension (ETCO2) was investigated; 146 treatments of 31 patients were analyzed. Significant differences were observed between agents for mean postictal pulse and blood pressure values. With methohexital, there was a clear postictal increase of mean blood pressure from 126/78 mm Hg to 161/102 mm Hg, whereas there was no increase with propofol (p = 0.00), and with methohexital, a postictal increase of the mean pulse rate from 81 to 90 beats/min and a slight decrease with propofol (79 to 78 beats/min). There were no differences in the SpO2 and ETCO2. The mean seizure duration for unilateral treatments was significantly longer with methohexital (52.7 s) compared with propofol (34.1 s; p = 0.000), but there was no difference for the seizure-quality measures: postictal suppression index (propofol 79.7%, methohexital 77.4%) and mean integrated amplitude (30.2/31.8) were the same for both anesthetic agents. The results show that differences in seizure duration are unrelated to seizure-quality measures.

Authors+Show Affiliations

Department of Psychiatry, Landesnervenklinik Salzburg, Austria.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9661091

Citation

Geretsegger, C, et al. "Propofol and Methohexital as Anesthetic Agents for Electroconvulsive Therapy (ECT): a Comparison of Seizure-quality Measures and Vital Signs." The Journal of ECT, vol. 14, no. 1, 1998, pp. 28-35.
Geretsegger C, Rochowanski E, Kartnig C, et al. Propofol and methohexital as anesthetic agents for electroconvulsive therapy (ECT): a comparison of seizure-quality measures and vital signs. J ECT. 1998;14(1):28-35.
Geretsegger, C., Rochowanski, E., Kartnig, C., & Unterrainer, A. F. (1998). Propofol and methohexital as anesthetic agents for electroconvulsive therapy (ECT): a comparison of seizure-quality measures and vital signs. The Journal of ECT, 14(1), 28-35.
Geretsegger C, et al. Propofol and Methohexital as Anesthetic Agents for Electroconvulsive Therapy (ECT): a Comparison of Seizure-quality Measures and Vital Signs. J ECT. 1998;14(1):28-35. PubMed PMID: 9661091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Propofol and methohexital as anesthetic agents for electroconvulsive therapy (ECT): a comparison of seizure-quality measures and vital signs. AU - Geretsegger,C, AU - Rochowanski,E, AU - Kartnig,C, AU - Unterrainer,A F, PY - 1998/7/14/pubmed PY - 1998/7/14/medline PY - 1998/7/14/entrez SP - 28 EP - 35 JF - The journal of ECT JO - J ECT VL - 14 IS - 1 N2 - In a randomized crossover study, the influence of the anesthetics methohexital and propofol on EEG seizure parameters, seizure-quality measures, vital signs, and oxygen saturation (SpO2) and end-tidal carbon dioxide tension (ETCO2) was investigated; 146 treatments of 31 patients were analyzed. Significant differences were observed between agents for mean postictal pulse and blood pressure values. With methohexital, there was a clear postictal increase of mean blood pressure from 126/78 mm Hg to 161/102 mm Hg, whereas there was no increase with propofol (p = 0.00), and with methohexital, a postictal increase of the mean pulse rate from 81 to 90 beats/min and a slight decrease with propofol (79 to 78 beats/min). There were no differences in the SpO2 and ETCO2. The mean seizure duration for unilateral treatments was significantly longer with methohexital (52.7 s) compared with propofol (34.1 s; p = 0.000), but there was no difference for the seizure-quality measures: postictal suppression index (propofol 79.7%, methohexital 77.4%) and mean integrated amplitude (30.2/31.8) were the same for both anesthetic agents. The results show that differences in seizure duration are unrelated to seizure-quality measures. SN - 1095-0680 UR - https://www.unboundmedicine.com/medline/citation/9661091/Propofol_and_methohexital_as_anesthetic_agents_for_electroconvulsive_therapy__ECT_:_a_comparison_of_seizure_quality_measures_and_vital_signs_ L2 - https://Insights.ovid.com/pubmed?pmid=9661091 DB - PRIME DP - Unbound Medicine ER -