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Antibody response to human cytomegalovirus (HCMV) glycoprotein B (gB) in AIDS patients with HCMV end-organ disease.
J Med Virol. 1998 Aug; 55(4):272-80.JM

Abstract

Human cytomegalovirus (HCMV)-specific antibody responses in HIV-1 infected individuals either with or without HCMV end-organ disease were examined to determine the whether development of HCMV disease was associated with a particular deficit in the antibody response. Antiwhole HCMV, anti-glycoprotein B (gB), and neutralizing antibody levels were higher in HIV-1 infected individuals than in healthy immunocompetent subjects, particularly in patients with AIDS either with or without HCMV-associated disease. Irrespective of location and spread of HCMV disease, patients who had received anti-HCMV therapy prior to sampling exhibited significantly higher anti-gB and neutralizing antibody titers than those who remained untreated. Likewise, patients with HCMV disease who were antigenemic or viremic had significantly lower anti-gB and neutralizing antibody titers than those who tested negative in either assay. Patients with untreated HCMV disease had significantly lower antibody titers than AIDS patients without disease. Analysis of the IgG subclass antibody responses to gB revealed no significant differences among HIV-1 infected individuals. These results suggest that levels of detectable anti-gB and HCMV neutralizing antibodies are inversely related to systemic viral load. Thus, antibodies with such specificities may be relevant in preventing the establishment of HCMV-associated disease or in modulating its progression.

Authors+Show Affiliations

Department of Microbiology, School of Medicine, University of Valencia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9661835

Citation

Alberola, J, et al. "Antibody Response to Human Cytomegalovirus (HCMV) Glycoprotein B (gB) in AIDS Patients With HCMV End-organ Disease." Journal of Medical Virology, vol. 55, no. 4, 1998, pp. 272-80.
Alberola J, Domínguez V, Cardeñoso L, et al. Antibody response to human cytomegalovirus (HCMV) glycoprotein B (gB) in AIDS patients with HCMV end-organ disease. J Med Virol. 1998;55(4):272-80.
Alberola, J., Domínguez, V., Cardeñoso, L., López-Aldeguer, J., Blanes, M., Estellés, F., Ricart, C., Pastor, A., Igual, R., & Navarro, D. (1998). Antibody response to human cytomegalovirus (HCMV) glycoprotein B (gB) in AIDS patients with HCMV end-organ disease. Journal of Medical Virology, 55(4), 272-80.
Alberola J, et al. Antibody Response to Human Cytomegalovirus (HCMV) Glycoprotein B (gB) in AIDS Patients With HCMV End-organ Disease. J Med Virol. 1998;55(4):272-80. PubMed PMID: 9661835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibody response to human cytomegalovirus (HCMV) glycoprotein B (gB) in AIDS patients with HCMV end-organ disease. AU - Alberola,J, AU - Domínguez,V, AU - Cardeñoso,L, AU - López-Aldeguer,J, AU - Blanes,M, AU - Estellés,F, AU - Ricart,C, AU - Pastor,A, AU - Igual,R, AU - Navarro,D, PY - 1998/7/14/pubmed PY - 2000/6/20/medline PY - 1998/7/14/entrez SP - 272 EP - 80 JF - Journal of medical virology JO - J Med Virol VL - 55 IS - 4 N2 - Human cytomegalovirus (HCMV)-specific antibody responses in HIV-1 infected individuals either with or without HCMV end-organ disease were examined to determine the whether development of HCMV disease was associated with a particular deficit in the antibody response. Antiwhole HCMV, anti-glycoprotein B (gB), and neutralizing antibody levels were higher in HIV-1 infected individuals than in healthy immunocompetent subjects, particularly in patients with AIDS either with or without HCMV-associated disease. Irrespective of location and spread of HCMV disease, patients who had received anti-HCMV therapy prior to sampling exhibited significantly higher anti-gB and neutralizing antibody titers than those who remained untreated. Likewise, patients with HCMV disease who were antigenemic or viremic had significantly lower anti-gB and neutralizing antibody titers than those who tested negative in either assay. Patients with untreated HCMV disease had significantly lower antibody titers than AIDS patients without disease. Analysis of the IgG subclass antibody responses to gB revealed no significant differences among HIV-1 infected individuals. These results suggest that levels of detectable anti-gB and HCMV neutralizing antibodies are inversely related to systemic viral load. Thus, antibodies with such specificities may be relevant in preventing the establishment of HCMV-associated disease or in modulating its progression. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/9661835/Antibody_response_to_human_cytomegalovirus__HCMV__glycoprotein_B__gB__in_AIDS_patients_with_HCMV_end_organ_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0146-6615&date=1998&volume=55&issue=4&spage=272 DB - PRIME DP - Unbound Medicine ER -