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Prevalence and genotypes of GB virus C/hepatitis G virus (GBV-C/HGV) and hepatitis C virus among patients infected with human immunodeficiency virus: evidence of GBV-C/HGV sexual transmission.
J Med Virol. 1998 Aug; 55(4):293-9.JM

Abstract

The development of new antiretroviral agents may improve survival of HIV-infected individuals, and therefore chronic viral hepatitis may become more relevant in these patients. The presence of GBV-C/HGV and hepatitis C virus (HCV) RNA were investigated by reverse transcriptase-nested polymerase chain reaction in plasma from 168 Spanish HIV-infected patients belonging to four different risk groups: intravenous drug users (IVDUs), hemophiliacs, homosexuals, and heterosexuals. GBV-C/HGV-RNA and HCV-RNA were detected in 18% and 43% of the patients, respectively. The prevalence of current infection with these viruses was notably high, 19% for GBV-C/HGV and 69% for HCV, among individuals with parenteral risk of infection (intravenous drug abusers and hemophiliacs), but sexual transmission with GBV-C/HGV was also suggested because 16.5% of patients with sexual risk, either homosexual or heterosexual, had GBV-C/HGV-RNA in plasma. Although investigation of GBV-C/HGV-RNA possibly underestimates the actual prevalence of infection with GBV-C/HGV, the above data suggest that sexual contact may play a relevant role in the spread of this virus. Phylogenetic analysis showed no evidence for clustering of NS3 sequences into different genotypes or subtypes of GBV-C/HGV.

Authors+Show Affiliations

Fundació IRSI-CAIXA, Laboratori de Retrovirologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9661838

Citation

Ibáñez, A, et al. "Prevalence and Genotypes of GB Virus C/hepatitis G Virus (GBV-C/HGV) and Hepatitis C Virus Among Patients Infected With Human Immunodeficiency Virus: Evidence of GBV-C/HGV Sexual Transmission." Journal of Medical Virology, vol. 55, no. 4, 1998, pp. 293-9.
Ibáñez A, Giménez-Barcons M, Tajahuerce A, et al. Prevalence and genotypes of GB virus C/hepatitis G virus (GBV-C/HGV) and hepatitis C virus among patients infected with human immunodeficiency virus: evidence of GBV-C/HGV sexual transmission. J Med Virol. 1998;55(4):293-9.
Ibáñez, A., Giménez-Barcons, M., Tajahuerce, A., Tural, C., Sirera, G., Clotet, B., Sánchez-Tapias, J. M., Rodés, J., Martínez, M. A., & Saiz, J. C. (1998). Prevalence and genotypes of GB virus C/hepatitis G virus (GBV-C/HGV) and hepatitis C virus among patients infected with human immunodeficiency virus: evidence of GBV-C/HGV sexual transmission. Journal of Medical Virology, 55(4), 293-9.
Ibáñez A, et al. Prevalence and Genotypes of GB Virus C/hepatitis G Virus (GBV-C/HGV) and Hepatitis C Virus Among Patients Infected With Human Immunodeficiency Virus: Evidence of GBV-C/HGV Sexual Transmission. J Med Virol. 1998;55(4):293-9. PubMed PMID: 9661838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and genotypes of GB virus C/hepatitis G virus (GBV-C/HGV) and hepatitis C virus among patients infected with human immunodeficiency virus: evidence of GBV-C/HGV sexual transmission. AU - Ibáñez,A, AU - Giménez-Barcons,M, AU - Tajahuerce,A, AU - Tural,C, AU - Sirera,G, AU - Clotet,B, AU - Sánchez-Tapias,J M, AU - Rodés,J, AU - Martínez,M A, AU - Saiz,J C, PY - 1998/7/14/pubmed PY - 2000/6/20/medline PY - 1998/7/14/entrez SP - 293 EP - 9 JF - Journal of medical virology JO - J Med Virol VL - 55 IS - 4 N2 - The development of new antiretroviral agents may improve survival of HIV-infected individuals, and therefore chronic viral hepatitis may become more relevant in these patients. The presence of GBV-C/HGV and hepatitis C virus (HCV) RNA were investigated by reverse transcriptase-nested polymerase chain reaction in plasma from 168 Spanish HIV-infected patients belonging to four different risk groups: intravenous drug users (IVDUs), hemophiliacs, homosexuals, and heterosexuals. GBV-C/HGV-RNA and HCV-RNA were detected in 18% and 43% of the patients, respectively. The prevalence of current infection with these viruses was notably high, 19% for GBV-C/HGV and 69% for HCV, among individuals with parenteral risk of infection (intravenous drug abusers and hemophiliacs), but sexual transmission with GBV-C/HGV was also suggested because 16.5% of patients with sexual risk, either homosexual or heterosexual, had GBV-C/HGV-RNA in plasma. Although investigation of GBV-C/HGV-RNA possibly underestimates the actual prevalence of infection with GBV-C/HGV, the above data suggest that sexual contact may play a relevant role in the spread of this virus. Phylogenetic analysis showed no evidence for clustering of NS3 sequences into different genotypes or subtypes of GBV-C/HGV. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/9661838/Prevalence_and_genotypes_of_GB_virus_C/hepatitis_G_virus__GBV_C/HGV__and_hepatitis_C_virus_among_patients_infected_with_human_immunodeficiency_virus:_evidence_of_GBV_C/HGV_sexual_transmission_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0146-6615&date=1998&volume=55&issue=4&spage=293 DB - PRIME DP - Unbound Medicine ER -