Tags

Type your tag names separated by a space and hit enter

Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans.
Am J Clin Nutr 1998; 68(1):52-9AJ

Abstract

The hemodynamic effects of highly purified eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) have not been evaluated in humans. We therefore conducted a randomized, double-blind, parallel-design intervention study to assess possible separate effects of EPA and DHA on blood pressure, heart rate, and cardiac mechanics. Healthy, nonsmoking men aged 36-56 y (n = 224) were randomly assigned to dietary supplementation with 4 g/d of ethyl ester concentrates of DHA or EPA or 4 g corn oil/d (control). Mean blood pressure at baseline was 122/77 mm Hg and was positively associated with concentrations of serum phospholipid saturated fatty acids. Blood pressure did not change during the intervention. Mean heart rate at baseline was 63.4 beats/min; it decreased 2.2 beats/min in the DHA group (P = 0.006 compared with control), increased 1.9 beats/min in the EPA group (P = 0.04 compared with control), and remained practically unchanged in the control group. In a pooled analysis, changes in heart rate were independent of baseline heart rate and were associated with changes in concentrations of serum phospholipid DHA and docosapentaenoic acid (22:5n-3). Echocardiography in a subsample of 52 men showed improved left ventricular diastolic filling in the marine oil groups compared with the corn oil group (P = 0.02). In contrast, an increase in plasma concentrations of saturated fatty acids was associated with delayed diastolic filling. We conclude that dietary DHA and EPA influence heart rate and that the fatty acid composition of plasma phospholipids may affect cardiac mechanics in humans.

Authors+Show Affiliations

Institute of Community Medicine, University of Tromsø, Norway. Sameline.Grimsgaard@ism.uit.noNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9665096

Citation

Grimsgaard, S, et al. "Effects of Highly Purified Eicosapentaenoic Acid and Docosahexaenoic Acid On Hemodynamics in Humans." The American Journal of Clinical Nutrition, vol. 68, no. 1, 1998, pp. 52-9.
Grimsgaard S, Bønaa KH, Hansen JB, et al. Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans. Am J Clin Nutr. 1998;68(1):52-9.
Grimsgaard, S., Bønaa, K. H., Hansen, J. B., & Myhre, E. S. (1998). Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans. The American Journal of Clinical Nutrition, 68(1), pp. 52-9.
Grimsgaard S, et al. Effects of Highly Purified Eicosapentaenoic Acid and Docosahexaenoic Acid On Hemodynamics in Humans. Am J Clin Nutr. 1998;68(1):52-9. PubMed PMID: 9665096.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans. AU - Grimsgaard,S, AU - Bønaa,K H, AU - Hansen,J B, AU - Myhre,E S, PY - 1998/7/17/pubmed PY - 1998/7/17/medline PY - 1998/7/17/entrez SP - 52 EP - 9 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 68 IS - 1 N2 - The hemodynamic effects of highly purified eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) have not been evaluated in humans. We therefore conducted a randomized, double-blind, parallel-design intervention study to assess possible separate effects of EPA and DHA on blood pressure, heart rate, and cardiac mechanics. Healthy, nonsmoking men aged 36-56 y (n = 224) were randomly assigned to dietary supplementation with 4 g/d of ethyl ester concentrates of DHA or EPA or 4 g corn oil/d (control). Mean blood pressure at baseline was 122/77 mm Hg and was positively associated with concentrations of serum phospholipid saturated fatty acids. Blood pressure did not change during the intervention. Mean heart rate at baseline was 63.4 beats/min; it decreased 2.2 beats/min in the DHA group (P = 0.006 compared with control), increased 1.9 beats/min in the EPA group (P = 0.04 compared with control), and remained practically unchanged in the control group. In a pooled analysis, changes in heart rate were independent of baseline heart rate and were associated with changes in concentrations of serum phospholipid DHA and docosapentaenoic acid (22:5n-3). Echocardiography in a subsample of 52 men showed improved left ventricular diastolic filling in the marine oil groups compared with the corn oil group (P = 0.02). In contrast, an increase in plasma concentrations of saturated fatty acids was associated with delayed diastolic filling. We conclude that dietary DHA and EPA influence heart rate and that the fatty acid composition of plasma phospholipids may affect cardiac mechanics in humans. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/9665096/Effects_of_highly_purified_eicosapentaenoic_acid_and_docosahexaenoic_acid_on_hemodynamics_in_humans_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/68.1.52 DB - PRIME DP - Unbound Medicine ER -