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Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors.
Life Sci. 1998; 63(1):PL1-6.LS

Abstract

Delta9-tetrahydrocannabinol (delta9-THC), cannabinol and cannabidiol are three important natural cannabinoids from the Marijuana plant (Cannabis sativa). Using [35S]GTP-gamma-S binding on rat cerebellar homogenate as an index of cannabinoid receptor activation we show that: delta9-THC does not induce the maximal effect obtained by classical cannabinoid receptor agonists such as CP55940. Moreover at high concentration delta9-THC exhibits antagonist properties. Cannabinol is a weak agonist on rat cerebellar cannabinoid receptors and cannabidiol behaves as an antagonist acting in the micromolar range.

Authors+Show Affiliations

Rhône-Poulenc Rorer S.A., C.R.V.A., Vitry-sur-Seine, France. Francois.PETITET@RP-RORER.FRNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9667767

Citation

Petitet, F, et al. "Complex Pharmacology of Natural Cannabinoids: Evidence for Partial Agonist Activity of Delta9-tetrahydrocannabinol and Antagonist Activity of Cannabidiol On Rat Brain Cannabinoid Receptors." Life Sciences, vol. 63, no. 1, 1998, pp. PL1-6.
Petitet F, Jeantaud B, Reibaud M, et al. Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors. Life Sci. 1998;63(1):PL1-6.
Petitet, F., Jeantaud, B., Reibaud, M., Imperato, A., & Dubroeucq, M. C. (1998). Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors. Life Sciences, 63(1), PL1-6.
Petitet F, et al. Complex Pharmacology of Natural Cannabinoids: Evidence for Partial Agonist Activity of Delta9-tetrahydrocannabinol and Antagonist Activity of Cannabidiol On Rat Brain Cannabinoid Receptors. Life Sci. 1998;63(1):PL1-6. PubMed PMID: 9667767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors. AU - Petitet,F, AU - Jeantaud,B, AU - Reibaud,M, AU - Imperato,A, AU - Dubroeucq,M C, PY - 1998/7/17/pubmed PY - 1998/7/17/medline PY - 1998/7/17/entrez SP - PL1 EP - 6 JF - Life sciences JO - Life Sci VL - 63 IS - 1 N2 - Delta9-tetrahydrocannabinol (delta9-THC), cannabinol and cannabidiol are three important natural cannabinoids from the Marijuana plant (Cannabis sativa). Using [35S]GTP-gamma-S binding on rat cerebellar homogenate as an index of cannabinoid receptor activation we show that: delta9-THC does not induce the maximal effect obtained by classical cannabinoid receptor agonists such as CP55940. Moreover at high concentration delta9-THC exhibits antagonist properties. Cannabinol is a weak agonist on rat cerebellar cannabinoid receptors and cannabidiol behaves as an antagonist acting in the micromolar range. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/9667767/Complex_pharmacology_of_natural_cannabinoids:_evidence_for_partial_agonist_activity_of_delta9_tetrahydrocannabinol_and_antagonist_activity_of_cannabidiol_on_rat_brain_cannabinoid_receptors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024320598002380 DB - PRIME DP - Unbound Medicine ER -