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RETRACTED ARTICLE

Prophylactic antiemetic therapy with granisetron-droperidol combination in patients undergoing laparoscopic cholecystectomy.
Can J Anaesth. 1998 Jun; 45(6):541-4.CJ

Abstract

PURPOSE

A relatively high incidence of postoperative nausea and vomiting (PONV) occurs in patients undergoing laparoscopic cholecystectomy. This study was undertaken to compare the efficacy of granisetron-droperidol combination with each drug alone for the prevention of PONV after laparoscopic cholecystectomy.

METHODS

In a randomized, double-blind manner, 150 female inpatients received 3 mg granisetron (Group G), 1.25 mg droperidol (Group D) or 3 mg granisetron plus 1.25 mg droperidol (Group GD)(n = 50 for each) i.v. immediately before the induction of anaesthesia. The same standard general anaesthetic technique, which consisted of isoflurane and nitrous oxide in oxygen, was used. Nausea, vomiting and safety assessments were performed continuously during the first 24 hr after anaesthesia.

RESULTS

Complete response, defined as no PONV and no administration of rescue antiemetic medication, was 86% in Group G, 64% in Group D and 98% in Group GD (P = 0.03 vs Group G, P = 0.001 vs Group D). No clinically adverse events were observed in any group.

CONCLUSION

Granisetron-droperidol combination is more effective than each antiemetic alone in the prevention of PONV after laparoscopic cholecystectomy.

Authors+Show Affiliations

Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Ibaraki, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Retracted Publication

Language

eng

PubMed ID

9669007

Citation

Fujii, Y, et al. "Prophylactic Antiemetic Therapy With Granisetron-droperidol Combination in Patients Undergoing Laparoscopic Cholecystectomy." Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, vol. 45, no. 6, 1998, pp. 541-4.
Fujii Y, Saitoh Y, Tanaka H, et al. Prophylactic antiemetic therapy with granisetron-droperidol combination in patients undergoing laparoscopic cholecystectomy. Can J Anaesth. 1998;45(6):541-4.
Fujii, Y., Saitoh, Y., Tanaka, H., & Toyooka, H. (1998). Prophylactic antiemetic therapy with granisetron-droperidol combination in patients undergoing laparoscopic cholecystectomy. Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, 45(6), 541-4.
Fujii Y, et al. Prophylactic Antiemetic Therapy With Granisetron-droperidol Combination in Patients Undergoing Laparoscopic Cholecystectomy. Can J Anaesth. 1998;45(6):541-4. PubMed PMID: 9669007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prophylactic antiemetic therapy with granisetron-droperidol combination in patients undergoing laparoscopic cholecystectomy. AU - Fujii,Y, AU - Saitoh,Y, AU - Tanaka,H, AU - Toyooka,H, PY - 1998/7/21/pubmed PY - 1998/7/21/medline PY - 1998/7/21/entrez SP - 541 EP - 4 JF - Canadian journal of anaesthesia = Journal canadien d'anesthesie JO - Can J Anaesth VL - 45 IS - 6 N2 - PURPOSE: A relatively high incidence of postoperative nausea and vomiting (PONV) occurs in patients undergoing laparoscopic cholecystectomy. This study was undertaken to compare the efficacy of granisetron-droperidol combination with each drug alone for the prevention of PONV after laparoscopic cholecystectomy. METHODS: In a randomized, double-blind manner, 150 female inpatients received 3 mg granisetron (Group G), 1.25 mg droperidol (Group D) or 3 mg granisetron plus 1.25 mg droperidol (Group GD)(n = 50 for each) i.v. immediately before the induction of anaesthesia. The same standard general anaesthetic technique, which consisted of isoflurane and nitrous oxide in oxygen, was used. Nausea, vomiting and safety assessments were performed continuously during the first 24 hr after anaesthesia. RESULTS: Complete response, defined as no PONV and no administration of rescue antiemetic medication, was 86% in Group G, 64% in Group D and 98% in Group GD (P = 0.03 vs Group G, P = 0.001 vs Group D). No clinically adverse events were observed in any group. CONCLUSION: Granisetron-droperidol combination is more effective than each antiemetic alone in the prevention of PONV after laparoscopic cholecystectomy. SN - 0832-610X UR - https://www.unboundmedicine.com/medline/citation/9669007/Prophylactic_antiemetic_therapy_with_granisetron_droperidol_combination_in_patients_undergoing_laparoscopic_cholecystectomy_ L2 - https://dx.doi.org/10.1007/BF03012704 DB - PRIME DP - Unbound Medicine ER -