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Ketoconazole shampoo: effect of long-term use in androgenic alopecia.
Dermatology. 1998; 196(4):474-7.D

Abstract

BACKGROUND

The pathogenesis of androgenic alopecia is not fully understood. A microbial-driven inflammatory reaction abutting on the hair follicles might participate in the hair status anomaly.

OBJECTIVE

The aim of our study was to determine if ketoconazole (KCZ) which is active against the scalp microflora and shows some intrinsic anti-inflammatory activity might improve alopecia.

METHOD

The effect of 2% KCZ shampoo was compared to that of an unmedicated shampoo used in combination with or without 2% minoxidil therapy.

RESULTS

Hair density and size and proportion of anagen follicles were improved almost similarly by both KCZ and minoxidil regimens. The sebum casual level appeared to be decreased by KCZ.

CONCLUSION

Comparative data suggest that there may be a significant action of KCZ upon the course of androgenic alopecia and that Malassezia spp. may play a role in the inflammatory reaction. The clinical significance of the results awaits further controlled study in a larger group of subjects.

Authors+Show Affiliations

Department of Dermatopathology, University of Liège, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

9669136

Citation

Piérard-Franchimont, C, et al. "Ketoconazole Shampoo: Effect of Long-term Use in Androgenic Alopecia." Dermatology (Basel, Switzerland), vol. 196, no. 4, 1998, pp. 474-7.
Piérard-Franchimont C, De Doncker P, Cauwenbergh G, et al. Ketoconazole shampoo: effect of long-term use in androgenic alopecia. Dermatology (Basel). 1998;196(4):474-7.
Piérard-Franchimont, C., De Doncker, P., Cauwenbergh, G., & Piérard, G. E. (1998). Ketoconazole shampoo: effect of long-term use in androgenic alopecia. Dermatology (Basel, Switzerland), 196(4), 474-7.
Piérard-Franchimont C, et al. Ketoconazole Shampoo: Effect of Long-term Use in Androgenic Alopecia. Dermatology (Basel). 1998;196(4):474-7. PubMed PMID: 9669136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ketoconazole shampoo: effect of long-term use in androgenic alopecia. AU - Piérard-Franchimont,C, AU - De Doncker,P, AU - Cauwenbergh,G, AU - Piérard,G E, PY - 1998/7/21/pubmed PY - 2000/10/6/medline PY - 1998/7/21/entrez SP - 474 EP - 7 JF - Dermatology (Basel, Switzerland) JO - Dermatology (Basel) VL - 196 IS - 4 N2 - BACKGROUND: The pathogenesis of androgenic alopecia is not fully understood. A microbial-driven inflammatory reaction abutting on the hair follicles might participate in the hair status anomaly. OBJECTIVE: The aim of our study was to determine if ketoconazole (KCZ) which is active against the scalp microflora and shows some intrinsic anti-inflammatory activity might improve alopecia. METHOD: The effect of 2% KCZ shampoo was compared to that of an unmedicated shampoo used in combination with or without 2% minoxidil therapy. RESULTS: Hair density and size and proportion of anagen follicles were improved almost similarly by both KCZ and minoxidil regimens. The sebum casual level appeared to be decreased by KCZ. CONCLUSION: Comparative data suggest that there may be a significant action of KCZ upon the course of androgenic alopecia and that Malassezia spp. may play a role in the inflammatory reaction. The clinical significance of the results awaits further controlled study in a larger group of subjects. SN - 1018-8665 UR - https://www.unboundmedicine.com/medline/citation/9669136/Ketoconazole_shampoo:_effect_of_long_term_use_in_androgenic_alopecia_ L2 - https://www.karger.com?DOI=10.1159/000017954 DB - PRIME DP - Unbound Medicine ER -