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Efficacy of pentoxifylline with aspirin in the treatment of frostbite in rats.
Indian J Med Res. 1998 May; 107:239-45.IJ

Abstract

The efficacy of pentoxifylline--a haemorrheologic agent along with aspirin--an analgesic agent was evaluated in the amelioration of the tissue damage due to experimentally induced frostbite in 5 groups (20 each) of rats with body weights ranging between 175 and 200 g. Frostbite was produced experimentally in the hind limbs by exposing the animals to -15 +/- 1 degrees C for 1 h using the harness technique, with simultaneous recording of rectal and environmental temperatures. The degree of tissue damage was assessed on the basis of tissue necrosis after 15 days. Administration of pentoxifylline (40 mg/kg bw) 30 min before and 30 min after the cold exposure followed by two doses of the same daily for the next 5 days along with aspirin (5 mg/kg bw) twice daily for the same duration only after cold exposure, resulted in significant improvement in the degree of tissue preservation. The findings of this preliminary study have brought to light the potential usefulness of these drugs in the treatment of frostbite. The combined pharmacological properties of these two drugs might have altered the haemorrheologic status of blood and produced the curative beneficial effect in improving tissue survival following experimentally induced frostbite in rats.

Authors+Show Affiliations

Department of Cold Physiology, Defence Institute of Physiology & Allied Sciences, Delhi.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9670622

Citation

Purkayastha, S S., et al. "Efficacy of Pentoxifylline With Aspirin in the Treatment of Frostbite in Rats." The Indian Journal of Medical Research, vol. 107, 1998, pp. 239-45.
Purkayastha SS, Roy A, Chauhan SK, et al. Efficacy of pentoxifylline with aspirin in the treatment of frostbite in rats. Indian J Med Res. 1998;107:239-45.
Purkayastha, S. S., Roy, A., Chauhan, S. K., Verma, S. S., & Selvamurthy, W. (1998). Efficacy of pentoxifylline with aspirin in the treatment of frostbite in rats. The Indian Journal of Medical Research, 107, 239-45.
Purkayastha SS, et al. Efficacy of Pentoxifylline With Aspirin in the Treatment of Frostbite in Rats. Indian J Med Res. 1998;107:239-45. PubMed PMID: 9670622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of pentoxifylline with aspirin in the treatment of frostbite in rats. AU - Purkayastha,S S, AU - Roy,A, AU - Chauhan,S K, AU - Verma,S S, AU - Selvamurthy,W, PY - 1998/7/22/pubmed PY - 1998/7/22/medline PY - 1998/7/22/entrez SP - 239 EP - 45 JF - The Indian journal of medical research JO - Indian J. Med. Res. VL - 107 N2 - The efficacy of pentoxifylline--a haemorrheologic agent along with aspirin--an analgesic agent was evaluated in the amelioration of the tissue damage due to experimentally induced frostbite in 5 groups (20 each) of rats with body weights ranging between 175 and 200 g. Frostbite was produced experimentally in the hind limbs by exposing the animals to -15 +/- 1 degrees C for 1 h using the harness technique, with simultaneous recording of rectal and environmental temperatures. The degree of tissue damage was assessed on the basis of tissue necrosis after 15 days. Administration of pentoxifylline (40 mg/kg bw) 30 min before and 30 min after the cold exposure followed by two doses of the same daily for the next 5 days along with aspirin (5 mg/kg bw) twice daily for the same duration only after cold exposure, resulted in significant improvement in the degree of tissue preservation. The findings of this preliminary study have brought to light the potential usefulness of these drugs in the treatment of frostbite. The combined pharmacological properties of these two drugs might have altered the haemorrheologic status of blood and produced the curative beneficial effect in improving tissue survival following experimentally induced frostbite in rats. SN - 0971-5916 UR - https://www.unboundmedicine.com/medline/citation/9670622/Efficacy_of_pentoxifylline_with_aspirin_in_the_treatment_of_frostbite_in_rats_ L2 - https://medlineplus.gov/bloodthinners.html DB - PRIME DP - Unbound Medicine ER -