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Is Barrett's esophagus characterized by more pronounced acid reflux than severe esophagitis?
Am J Gastroenterol 1998; 93(7):1068-72AJ

Abstract

OBJECTIVE

Barrett's esophagus is related to gastroesophageal reflux disease (GERD). However, only a small fraction of patients with GERD develop Barrett's esophagus. We evaluated whether gastroesophageal acid reflux is more pronounced in Barrett's patients than in patients with moderate or severe endoscopic esophagitis.

METHODS

Retrospective evaluation of results of esophageal manometry and 24 hour ambulatory pH monitoring performed between 1990 and 1996 at the Leiden University Medical Center in those patients who also underwent endoscopy < or = 3 months before pH-metry. Included were 51 patients with Barrett's esophagus, 30 patients with severe esophagitis, 45 patients with moderate esophagitis, and 24 healthy control subjects.

RESULTS

Patients with Barrett's esophagus had significantly increased acid reflux time (p < 0.01-0.05) compared to patients with moderate, but not compared to patients with severe esophagitis. Distal esophageal body motility and LES pressure were significantly (p < 0.01-0.05) reduced in patients with Barrett's esophagus compared to patients with moderate esophagitis but not compared to those with severe esophagitis.

CONCLUSION

Although acid reflux is increased in patients with Barrett's esophagus and esophageal motility is impaired, other factors apart from acid exposure and motility contribute to the development of Barrett's esophagus.

Authors+Show Affiliations

Department of Gastroenterology-Hepatology, Leiden University Medical Center, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9672332

Citation

Coenraad, M, et al. "Is Barrett's Esophagus Characterized By More Pronounced Acid Reflux Than Severe Esophagitis?" The American Journal of Gastroenterology, vol. 93, no. 7, 1998, pp. 1068-72.
Coenraad M, Masclee AA, Straathof JW, et al. Is Barrett's esophagus characterized by more pronounced acid reflux than severe esophagitis? Am J Gastroenterol. 1998;93(7):1068-72.
Coenraad, M., Masclee, A. A., Straathof, J. W., Ganesh, S., Griffioen, G., & Lamers, C. B. (1998). Is Barrett's esophagus characterized by more pronounced acid reflux than severe esophagitis? The American Journal of Gastroenterology, 93(7), pp. 1068-72.
Coenraad M, et al. Is Barrett's Esophagus Characterized By More Pronounced Acid Reflux Than Severe Esophagitis. Am J Gastroenterol. 1998;93(7):1068-72. PubMed PMID: 9672332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is Barrett's esophagus characterized by more pronounced acid reflux than severe esophagitis? AU - Coenraad,M, AU - Masclee,A A, AU - Straathof,J W, AU - Ganesh,S, AU - Griffioen,G, AU - Lamers,C B, PY - 1998/7/22/pubmed PY - 1998/7/22/medline PY - 1998/7/22/entrez SP - 1068 EP - 72 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 93 IS - 7 N2 - OBJECTIVE: Barrett's esophagus is related to gastroesophageal reflux disease (GERD). However, only a small fraction of patients with GERD develop Barrett's esophagus. We evaluated whether gastroesophageal acid reflux is more pronounced in Barrett's patients than in patients with moderate or severe endoscopic esophagitis. METHODS: Retrospective evaluation of results of esophageal manometry and 24 hour ambulatory pH monitoring performed between 1990 and 1996 at the Leiden University Medical Center in those patients who also underwent endoscopy < or = 3 months before pH-metry. Included were 51 patients with Barrett's esophagus, 30 patients with severe esophagitis, 45 patients with moderate esophagitis, and 24 healthy control subjects. RESULTS: Patients with Barrett's esophagus had significantly increased acid reflux time (p < 0.01-0.05) compared to patients with moderate, but not compared to patients with severe esophagitis. Distal esophageal body motility and LES pressure were significantly (p < 0.01-0.05) reduced in patients with Barrett's esophagus compared to patients with moderate esophagitis but not compared to those with severe esophagitis. CONCLUSION: Although acid reflux is increased in patients with Barrett's esophagus and esophageal motility is impaired, other factors apart from acid exposure and motility contribute to the development of Barrett's esophagus. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/9672332/Is_Barrett's_esophagus_characterized_by_more_pronounced_acid_reflux_than_severe_esophagitis L2 - http://Insights.ovid.com/pubmed?pmid=9672332 DB - PRIME DP - Unbound Medicine ER -