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Prevalence of Helicobacter pylori infection and gastric mucosal abnormalities in chronic pancreatitis.
Am J Gastroenterol. 1998 Jul; 93(7):1097-100.AJ

Abstract

OBJECTIVE

Chronic pancreatitis is often associated with abnormal gastric acid secretion. However, previous studies have taken into consideration neither the potential role of Helicobacter pylori (H. pylori) infection nor histological features of the gastric mucosa in this context. The aim of this study was to analyze the prevalence of H. pylori infection as well as the pattern of gastritis in patients with chronic pancreatitis.

METHODS

Forty patients with chronic alcoholic pancreatitis were included in the study: 40 patients with alcoholic liver cirrhosis and normal exocrine pancreatic function and 40 asymptomatic nonalcoholic subjects matched for age and sex used as control subjects. Endoscopy was performed in all patients, and five biopsy specimens from the antrum (three from the gastric body and two from the cardia) were taken for histological grading of gastritis and H. pylori assessment.

RESULTS

Prevalence of H. pylori infection was similar in subjects with chronic pancreatitis (38%), asymptomatic subjects (28%) and liver cirrhosis (30%). Topography and expression of H. pylori-associated chronic gastritis was also not different among the three groups of subjects. In H. pylori-negative subjects, the presence of moderate to severe chronic antral gastritis was significantly more common in patients with chronic pancreatitis (40%) than in subjects with liver cirrhosis (18%) and in asymptomatic subjects (14%) (p < 0.05). No difference was found among the three groups of patients with regard to gastritis activity, atrophy, and intestinal metaplasia in the various gastric regions. The chronicity grade of gastritis did not correlate with the severity of pancreatic insufficiency.

CONCLUSION

Prevalence of H. pylori infection is not different in patients with chronic pancreatitis as compared with subjects alcoholic liver cirrhosis and asymptomatic subjects. A severe H. pylori-negative chronic gastritis is more common in patients with chronic pancreatitis. This chronic inflammation of the gastric mucosa could contribute to determining the changes in gastric physiology described in patients with chronic pancreatitis.

Authors+Show Affiliations

Department of Gastroenterology and Pathology, University of Magdeburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9672337

Citation

Manes, G, et al. "Prevalence of Helicobacter Pylori Infection and Gastric Mucosal Abnormalities in Chronic Pancreatitis." The American Journal of Gastroenterology, vol. 93, no. 7, 1998, pp. 1097-100.
Manes G, Dominguez-Muñoz JE, Hackelsberger A, et al. Prevalence of Helicobacter pylori infection and gastric mucosal abnormalities in chronic pancreatitis. Am J Gastroenterol. 1998;93(7):1097-100.
Manes, G., Dominguez-Muñoz, J. E., Hackelsberger, A., Leodolter, A., Rössner, A., & Malfertheiner, P. (1998). Prevalence of Helicobacter pylori infection and gastric mucosal abnormalities in chronic pancreatitis. The American Journal of Gastroenterology, 93(7), 1097-100.
Manes G, et al. Prevalence of Helicobacter Pylori Infection and Gastric Mucosal Abnormalities in Chronic Pancreatitis. Am J Gastroenterol. 1998;93(7):1097-100. PubMed PMID: 9672337.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of Helicobacter pylori infection and gastric mucosal abnormalities in chronic pancreatitis. AU - Manes,G, AU - Dominguez-Muñoz,J E, AU - Hackelsberger,A, AU - Leodolter,A, AU - Rössner,A, AU - Malfertheiner,P, PY - 1998/7/22/pubmed PY - 1998/7/22/medline PY - 1998/7/22/entrez SP - 1097 EP - 100 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 93 IS - 7 N2 - OBJECTIVE: Chronic pancreatitis is often associated with abnormal gastric acid secretion. However, previous studies have taken into consideration neither the potential role of Helicobacter pylori (H. pylori) infection nor histological features of the gastric mucosa in this context. The aim of this study was to analyze the prevalence of H. pylori infection as well as the pattern of gastritis in patients with chronic pancreatitis. METHODS: Forty patients with chronic alcoholic pancreatitis were included in the study: 40 patients with alcoholic liver cirrhosis and normal exocrine pancreatic function and 40 asymptomatic nonalcoholic subjects matched for age and sex used as control subjects. Endoscopy was performed in all patients, and five biopsy specimens from the antrum (three from the gastric body and two from the cardia) were taken for histological grading of gastritis and H. pylori assessment. RESULTS: Prevalence of H. pylori infection was similar in subjects with chronic pancreatitis (38%), asymptomatic subjects (28%) and liver cirrhosis (30%). Topography and expression of H. pylori-associated chronic gastritis was also not different among the three groups of subjects. In H. pylori-negative subjects, the presence of moderate to severe chronic antral gastritis was significantly more common in patients with chronic pancreatitis (40%) than in subjects with liver cirrhosis (18%) and in asymptomatic subjects (14%) (p < 0.05). No difference was found among the three groups of patients with regard to gastritis activity, atrophy, and intestinal metaplasia in the various gastric regions. The chronicity grade of gastritis did not correlate with the severity of pancreatic insufficiency. CONCLUSION: Prevalence of H. pylori infection is not different in patients with chronic pancreatitis as compared with subjects alcoholic liver cirrhosis and asymptomatic subjects. A severe H. pylori-negative chronic gastritis is more common in patients with chronic pancreatitis. This chronic inflammation of the gastric mucosa could contribute to determining the changes in gastric physiology described in patients with chronic pancreatitis. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/9672337/Prevalence_of_Helicobacter_pylori_infection_and_gastric_mucosal_abnormalities_in_chronic_pancreatitis_ L2 - https://Insights.ovid.com/pubmed?pmid=9672337 DB - PRIME DP - Unbound Medicine ER -