Tags

Type your tag names separated by a space and hit enter

Microbiology of common infections in the upper respiratory tract.
Prim Care. 1998 Sep; 25(3):633-48.PC

Abstract

The management of upper respiratory tract infections has become more difficult because of the recent increase in the number of penicillin-resistant organisms. The bacteria that predominate in otitis media and sinusitis can resist penicillin through the production of the enzyme beta-lactamase (Haemophilus influenzae and Moraxella catarrhalis in acute infections and Staphylococcus aureus and Prevotella and Fusobacteria spp in chronic infections) or through changes in penicillin-binding sites (Streptococcus pneumoniae). beta-lactamase-producing bacteria can express their pathogenicity directly through their ability to cause infections and indirectly by production of the enzyme, thus protecting penicillin-susceptible pathogens from penicillins. This phenomenon may explain penicillin's failure in the treatment of Group A beta-hemolytic streptococcal (GABHS) tonsillitis. An additional cause for penicillin failure is the absence among the normal tonsillar bacterial flora of streptococcal species that are capable of interfering with the growth of GABHS. Proper use of antimicrobial therapy, including those therapies that are effective against penicillin-resistant bacteria, is the cornerstone of management of upper respiratory tract infections.

Links

Publisher Full Text

Authors+Show Affiliations

Brook I
Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA.

MeSH

AdultAnti-Bacterial AgentsChildDrug Resistance, MicrobialHumansOtitis MediaRespiratory Tract InfectionsSinusitisTonsillitis

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9673324

Citation

Brook, I. "Microbiology of Common Infections in the Upper Respiratory Tract." Primary Care, vol. 25, no. 3, 1998, pp. 633-48.
Brook I. Microbiology of common infections in the upper respiratory tract. Prim Care. 1998;25(3):633-48.
Brook, I. (1998). Microbiology of common infections in the upper respiratory tract. Primary Care, 25(3), 633-48.
Brook I. Microbiology of Common Infections in the Upper Respiratory Tract. Prim Care. 1998;25(3):633-48. PubMed PMID: 9673324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microbiology of common infections in the upper respiratory tract. A1 - Brook,I, PY - 1998/7/23/pubmed PY - 1998/7/23/medline PY - 1998/7/23/entrez SP - 633 EP - 48 JF - Primary care JO - Prim Care VL - 25 IS - 3 N2 - The management of upper respiratory tract infections has become more difficult because of the recent increase in the number of penicillin-resistant organisms. The bacteria that predominate in otitis media and sinusitis can resist penicillin through the production of the enzyme beta-lactamase (Haemophilus influenzae and Moraxella catarrhalis in acute infections and Staphylococcus aureus and Prevotella and Fusobacteria spp in chronic infections) or through changes in penicillin-binding sites (Streptococcus pneumoniae). beta-lactamase-producing bacteria can express their pathogenicity directly through their ability to cause infections and indirectly by production of the enzyme, thus protecting penicillin-susceptible pathogens from penicillins. This phenomenon may explain penicillin's failure in the treatment of Group A beta-hemolytic streptococcal (GABHS) tonsillitis. An additional cause for penicillin failure is the absence among the normal tonsillar bacterial flora of streptococcal species that are capable of interfering with the growth of GABHS. Proper use of antimicrobial therapy, including those therapies that are effective against penicillin-resistant bacteria, is the cornerstone of management of upper respiratory tract infections. SN - 0095-4543 UR - https://www.unboundmedicine.com/medline/citation/9673324/Microbiology_of_common_infections_in_the_upper_respiratory_tract_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0095-4543(15)30006-3 DB - PRIME DP - Unbound Medicine ER -