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Regulation of netrin-1a expression by hedgehog proteins.
Mol Cell Neurosci. 1998 Jul; 11(4):194-205.MC

Abstract

Netrins, a family of growth cone guidance molecules, are expressed both in the ventral neural tube and in subsets of mesodermal cells. In an effort to better understand the regulation of netrins, we examined the expression of netrin-1a in mutant cyclops, no tail, and floating head zebrafish embryos, in which axial midline structures are perturbed. Netrin-1a expression requires signals present in notochord and floor plate cells. In the myotome, but not the neural tube, netrin-1a expression requires sonic hedgehog. In embryos lacking sonic hedgehog, the sonic-you locus, netrin-1a expression is reduced or absent in the myotomes but present in the neural tube. Embryos lacking sonic hedgehog express tiggy-winkle hedgehog in the floor plate, suggesting that, in the neural tube, tiggy-winkle hedgehog can compensate for the lack of sonic hedgehog in inducing netrin-1a expression. Ectopic expression of sonic hedgehog, tiggy-winkle hedgehog, or echidna hedgehog induces ectopic netrin-1a expression in the neural tube, and ectopic expression of sonic hedgehog or tiggy-winkle hedgehog, but not echidna hedgehog, induces ectopic netrin-1a expression in somites. These data demonstrate that in vertebrates netrin expression is regulated by Hedgehog signaling.

Authors+Show Affiliations

Department of Biology, University of Michigan, Ann Arbor, Michigan, 48109-1048, USA. jdlauder@umich.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9675051

Citation

Lauderdale, J D., et al. "Regulation of Netrin-1a Expression By Hedgehog Proteins." Molecular and Cellular Neurosciences, vol. 11, no. 4, 1998, pp. 194-205.
Lauderdale JD, Pasquali SK, Fazel R, et al. Regulation of netrin-1a expression by hedgehog proteins. Mol Cell Neurosci. 1998;11(4):194-205.
Lauderdale, J. D., Pasquali, S. K., Fazel, R., van Eeden, F. J., Schauerte, H. E., Haffter, P., & Kuwada, J. Y. (1998). Regulation of netrin-1a expression by hedgehog proteins. Molecular and Cellular Neurosciences, 11(4), 194-205.
Lauderdale JD, et al. Regulation of Netrin-1a Expression By Hedgehog Proteins. Mol Cell Neurosci. 1998;11(4):194-205. PubMed PMID: 9675051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of netrin-1a expression by hedgehog proteins. AU - Lauderdale,J D, AU - Pasquali,S K, AU - Fazel,R, AU - van Eeden,F J, AU - Schauerte,H E, AU - Haffter,P, AU - Kuwada,J Y, PY - 1998/7/24/pubmed PY - 1998/7/24/medline PY - 1998/7/24/entrez SP - 194 EP - 205 JF - Molecular and cellular neurosciences JO - Mol Cell Neurosci VL - 11 IS - 4 N2 - Netrins, a family of growth cone guidance molecules, are expressed both in the ventral neural tube and in subsets of mesodermal cells. In an effort to better understand the regulation of netrins, we examined the expression of netrin-1a in mutant cyclops, no tail, and floating head zebrafish embryos, in which axial midline structures are perturbed. Netrin-1a expression requires signals present in notochord and floor plate cells. In the myotome, but not the neural tube, netrin-1a expression requires sonic hedgehog. In embryos lacking sonic hedgehog, the sonic-you locus, netrin-1a expression is reduced or absent in the myotomes but present in the neural tube. Embryos lacking sonic hedgehog express tiggy-winkle hedgehog in the floor plate, suggesting that, in the neural tube, tiggy-winkle hedgehog can compensate for the lack of sonic hedgehog in inducing netrin-1a expression. Ectopic expression of sonic hedgehog, tiggy-winkle hedgehog, or echidna hedgehog induces ectopic netrin-1a expression in the neural tube, and ectopic expression of sonic hedgehog or tiggy-winkle hedgehog, but not echidna hedgehog, induces ectopic netrin-1a expression in somites. These data demonstrate that in vertebrates netrin expression is regulated by Hedgehog signaling. SN - 1044-7431 UR - https://www.unboundmedicine.com/medline/citation/9675051/Regulation_of_netrin_1a_expression_by_hedgehog_proteins_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1044-7431(98)90015-X DB - PRIME DP - Unbound Medicine ER -