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Stress response dampening: effects of gender and family history of alcoholism and anxiety disorders.
Psychopharmacology (Berl) 1998; 137(4):311-20P

Abstract

One hundred and fifteen non-alcoholic social drinkers, ages 21-30 years, were selected on the basis of parental history of alcoholism and/or anxiety disorders to participate in a laboratory study of stress response dampening (SRD) effects of alcohol. The following four risk groups were identified based on the diagnoses of both parents: 1) alcoholism (ALC+), (2) alcoholism and anxiety disorder (ALCANX+), (3) anxiety (ANX+), and (4) no psychiatric diagnoses (FH-). Subjects were randomly assigned to receive a placebo or alcohol (0.85 g/kg) beverage, following which cardiovascular measures and self-reports of anxiety were monitored prior to, during and after a speech stressor. Women with a family history of alcoholism and women with a family history of anxiety disorders showed strong SRD effects of alcohol on heart rate and pulse transit time. Men with a family history of anxiety disorders showed evidence of increased subjective response to stress during the alcohol beverage condition. Finally, SRD effects of alcohol were not found for male subjects, and this was attributed to their heavier drinking histories and lower breath alcohol levels as compared to women. Implications of the SRD effects in women are discussed in the context of the comorbid association between alcoholism and anxiety disorders.

Authors+Show Affiliations

Yale University School of Medicine, New Haven, CT 06511, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9676889

Citation

Sinha, R, et al. "Stress Response Dampening: Effects of Gender and Family History of Alcoholism and Anxiety Disorders." Psychopharmacology, vol. 137, no. 4, 1998, pp. 311-20.
Sinha R, Robinson J, O'Malley S. Stress response dampening: effects of gender and family history of alcoholism and anxiety disorders. Psychopharmacology (Berl). 1998;137(4):311-20.
Sinha, R., Robinson, J., & O'Malley, S. (1998). Stress response dampening: effects of gender and family history of alcoholism and anxiety disorders. Psychopharmacology, 137(4), pp. 311-20.
Sinha R, Robinson J, O'Malley S. Stress Response Dampening: Effects of Gender and Family History of Alcoholism and Anxiety Disorders. Psychopharmacology (Berl). 1998;137(4):311-20. PubMed PMID: 9676889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stress response dampening: effects of gender and family history of alcoholism and anxiety disorders. AU - Sinha,R, AU - Robinson,J, AU - O'Malley,S, PY - 1998/7/24/pubmed PY - 1998/7/24/medline PY - 1998/7/24/entrez SP - 311 EP - 20 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 137 IS - 4 N2 - One hundred and fifteen non-alcoholic social drinkers, ages 21-30 years, were selected on the basis of parental history of alcoholism and/or anxiety disorders to participate in a laboratory study of stress response dampening (SRD) effects of alcohol. The following four risk groups were identified based on the diagnoses of both parents: 1) alcoholism (ALC+), (2) alcoholism and anxiety disorder (ALCANX+), (3) anxiety (ANX+), and (4) no psychiatric diagnoses (FH-). Subjects were randomly assigned to receive a placebo or alcohol (0.85 g/kg) beverage, following which cardiovascular measures and self-reports of anxiety were monitored prior to, during and after a speech stressor. Women with a family history of alcoholism and women with a family history of anxiety disorders showed strong SRD effects of alcohol on heart rate and pulse transit time. Men with a family history of anxiety disorders showed evidence of increased subjective response to stress during the alcohol beverage condition. Finally, SRD effects of alcohol were not found for male subjects, and this was attributed to their heavier drinking histories and lower breath alcohol levels as compared to women. Implications of the SRD effects in women are discussed in the context of the comorbid association between alcoholism and anxiety disorders. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/9676889/Stress_response_dampening:_effects_of_gender_and_family_history_of_alcoholism_and_anxiety_disorders_ L2 - https://dx.doi.org/10.1007/s002130050624 DB - PRIME DP - Unbound Medicine ER -