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Three new ellagic acid derivatives from the bark of Eschweilera coriacea from the Suriname rainforest.
J Nat Prod. 1998 Jul; 61(7):901-6.JN

Abstract

Bioassay-guided fractionation of Eschweilera coriacea collected in the lowland wet forest of Suriname yielded the new but only weakly active ellagic acid derivative eschweilenol A (1) and the two new but inactive ellagic acid derivatives eschweilenol B (2) and eschweilenol C (3). The four known compounds, sucrose, ellagic acid, 3-O-galloylepigallocatechin, and epigallocatechin, were also isolated. The structures of the three new compounds were determined by spectrometric methods, primarily from the HMQC, HMBC, NOESY, and ROESY NMR techniques, and chemical methods, including methylation and triethylsilylation. The location of a hydroxyl group in one ellagic acid derivative was determined by a new technique involving an NOE correlation of the protons of a triethylsilyl derivative with a proton on a neighboring aromatic ring.

Authors+Show Affiliations

Yang SW
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0212, USA.
Zhou BN
No affiliation info available
Wisse JH
No affiliation info available
Evans R
No affiliation info available
van der Werff H
No affiliation info available
Miller JS
No affiliation info available
Kingston DG
No affiliation info available

MeSH

Antifungal AgentsCarbohydrate SequenceChromatography, Thin LayerEllagic AcidMagnetic Resonance SpectroscopyMolecular Sequence DataPlant EpidermisPlants, MedicinalSpectrometry, Mass, Fast Atom BombardmentSpectrophotometry, UltravioletSurinameYeasts

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9677272

Citation

Yang, S W., et al. "Three New Ellagic Acid Derivatives From the Bark of Eschweilera Coriacea From the Suriname Rainforest." Journal of Natural Products, vol. 61, no. 7, 1998, pp. 901-6.
Yang SW, Zhou BN, Wisse JH, et al. Three new ellagic acid derivatives from the bark of Eschweilera coriacea from the Suriname rainforest. J Nat Prod. 1998;61(7):901-6.
Yang, S. W., Zhou, B. N., Wisse, J. H., Evans, R., van der Werff, H., Miller, J. S., & Kingston, D. G. (1998). Three new ellagic acid derivatives from the bark of Eschweilera coriacea from the Suriname rainforest. Journal of Natural Products, 61(7), 901-6.
Yang SW, et al. Three New Ellagic Acid Derivatives From the Bark of Eschweilera Coriacea From the Suriname Rainforest. J Nat Prod. 1998;61(7):901-6. PubMed PMID: 9677272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Three new ellagic acid derivatives from the bark of Eschweilera coriacea from the Suriname rainforest. AU - Yang,S W, AU - Zhou,B N, AU - Wisse,J H, AU - Evans,R, AU - van der Werff,H, AU - Miller,J S, AU - Kingston,D G, PY - 1998/7/25/pubmed PY - 1998/7/25/medline PY - 1998/7/25/entrez SP - 901 EP - 6 JF - Journal of natural products JO - J Nat Prod VL - 61 IS - 7 N2 - Bioassay-guided fractionation of Eschweilera coriacea collected in the lowland wet forest of Suriname yielded the new but only weakly active ellagic acid derivative eschweilenol A (1) and the two new but inactive ellagic acid derivatives eschweilenol B (2) and eschweilenol C (3). The four known compounds, sucrose, ellagic acid, 3-O-galloylepigallocatechin, and epigallocatechin, were also isolated. The structures of the three new compounds were determined by spectrometric methods, primarily from the HMQC, HMBC, NOESY, and ROESY NMR techniques, and chemical methods, including methylation and triethylsilylation. The location of a hydroxyl group in one ellagic acid derivative was determined by a new technique involving an NOE correlation of the protons of a triethylsilyl derivative with a proton on a neighboring aromatic ring. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/9677272/Three_new_ellagic_acid_derivatives_from_the_bark_of_Eschweilera_coriacea_from_the_Suriname_rainforest_ L2 - https://doi.org/10.1021/np980046u DB - PRIME DP - Unbound Medicine ER -