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On the employment of lambda carrageenan in a matrix system. III. Optimization of a lambda carrageenan-HPMC hydrophilic matrix.
J Control Release. 1998 Feb 12; 51(2-3):231-9.JC

Abstract

The lambda carrageenan/HPMC ratio in matrix tablets has been optimized in order to obtain pH-independent release profiles of chlorpheniramine maleate, a freely soluble drug. Release profiles in acidic (pH1.2) and neutral (pH 6.8) media were fitted according to the Weibull and the power law models. Model independent parameters(t50% and the percentage of drug released after 2 h) were also calculated. The Weibull parameters were found suitable to describe the dependence of the release profiles on matrix composition. Preparation and testing of the optimized formulation showed linear and pH-independent release profiles lasting about 24 h, in good accordance with the values predicted by the optimization procedure.

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Authors+Show Affiliations

Bonferoni MC
Department of Pharmaceutical Chemistry, University of Pavia, Italy.
Rossi S
No affiliation info available
Ferrari F
No affiliation info available
Bertoni M
No affiliation info available
Bolhuis GK
No affiliation info available
Caramella C
No affiliation info available

MeSH

CarrageenanDelayed-Action PreparationsHydrogen-Ion ConcentrationLactoseMethylcelluloseModels, TheoreticalOxazinesRegression Analysis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9685921

Citation

Bonferoni, M C., et al. "On the Employment of Lambda Carrageenan in a Matrix System. III. Optimization of a Lambda carrageenan-HPMC Hydrophilic Matrix." Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 51, no. 2-3, 1998, pp. 231-9.
Bonferoni MC, Rossi S, Ferrari F, et al. On the employment of lambda carrageenan in a matrix system. III. Optimization of a lambda carrageenan-HPMC hydrophilic matrix. J Control Release. 1998;51(2-3):231-9.
Bonferoni, M. C., Rossi, S., Ferrari, F., Bertoni, M., Bolhuis, G. K., & Caramella, C. (1998). On the employment of lambda carrageenan in a matrix system. III. Optimization of a lambda carrageenan-HPMC hydrophilic matrix. Journal of Controlled Release : Official Journal of the Controlled Release Society, 51(2-3), 231-9.
Bonferoni MC, et al. On the Employment of Lambda Carrageenan in a Matrix System. III. Optimization of a Lambda carrageenan-HPMC Hydrophilic Matrix. J Control Release. 1998 Feb 12;51(2-3):231-9. PubMed PMID: 9685921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - On the employment of lambda carrageenan in a matrix system. III. Optimization of a lambda carrageenan-HPMC hydrophilic matrix. AU - Bonferoni,M C, AU - Rossi,S, AU - Ferrari,F, AU - Bertoni,M, AU - Bolhuis,G K, AU - Caramella,C, PY - 1998/8/1/pubmed PY - 1998/8/1/medline PY - 1998/8/1/entrez SP - 231 EP - 9 JF - Journal of controlled release : official journal of the Controlled Release Society JO - J Control Release VL - 51 IS - 2-3 N2 - The lambda carrageenan/HPMC ratio in matrix tablets has been optimized in order to obtain pH-independent release profiles of chlorpheniramine maleate, a freely soluble drug. Release profiles in acidic (pH1.2) and neutral (pH 6.8) media were fitted according to the Weibull and the power law models. Model independent parameters(t50% and the percentage of drug released after 2 h) were also calculated. The Weibull parameters were found suitable to describe the dependence of the release profiles on matrix composition. Preparation and testing of the optimized formulation showed linear and pH-independent release profiles lasting about 24 h, in good accordance with the values predicted by the optimization procedure. SN - 0168-3659 UR - https://www.unboundmedicine.com/medline/citation/9685921/On_the_employment_of_lambda_carrageenan_in_a_matrix_system__III__Optimization_of_a_lambda_carrageenan_HPMC_hydrophilic_matrix_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-3659(97)00175-2 DB - PRIME DP - Unbound Medicine ER -