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Antisense targeting of the urokinase receptor blocks urokinase-dependent proliferation, chemoinvasion, and chemotaxis of human synovial cells and chondrocytes in vitro.
Proc Assoc Am Physicians. 1998 Jul-Aug; 110(4):340-50.PA

Abstract

Proliferation and invasion of synovial pannus in rheumatoid arthritis and cartilage remodeling in osteoarthritis are key events in development of disability of arthritic joints. The mechanisms that trigger these events are still poorly understood. The production of urokinase-type plasminogen activator (u-PA) by synovial cells and chondrocytes and the subsequent interaction of u-PA with its membrane receptor (u-PAR) is under the control of a variety of growth factors and cytokines released within the inflamed joints. Here we show that u-PA, on interaction with the specific receptor, regulates movement and invasion as well as proliferation of human synovial cells and chondrocytes. Targeting the urokinase receptor with an antisense oligonucleotide blocks the u-PA-dependent synoviocyte and chondrocyte proliferation and chemoinvasion, suggesting a possible use for this new class of drugs in the progression of the disease in rheumatoid arthritis and osteoarthritis.

Authors+Show Affiliations

Fibbi G
Institute of General Pathology of Florence University, Firenze, Italy.
Pucci M
No affiliation info available
Serni U
No affiliation info available
Cerinic MM
No affiliation info available
Del Rosso M
No affiliation info available

MeSH

Cartilage, ArticularCell DivisionCells, CulturedChemotaxisChondrocytesDose-Response Relationship, DrugExtracellular MatrixGrowth InhibitorsHumansOligonucleotides, AntisenseRNA, MessengerReceptors, Cell SurfaceReceptors, Urokinase Plasminogen ActivatorSynovial FluidUrokinase-Type Plasminogen Activator

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9686682

Citation

Fibbi, G, et al. "Antisense Targeting of the Urokinase Receptor Blocks Urokinase-dependent Proliferation, Chemoinvasion, and Chemotaxis of Human Synovial Cells and Chondrocytes in Vitro." Proceedings of the Association of American Physicians, vol. 110, no. 4, 1998, pp. 340-50.
Fibbi G, Pucci M, Serni U, et al. Antisense targeting of the urokinase receptor blocks urokinase-dependent proliferation, chemoinvasion, and chemotaxis of human synovial cells and chondrocytes in vitro. Proc Assoc Am Physicians. 1998;110(4):340-50.
Fibbi, G., Pucci, M., Serni, U., Cerinic, M. M., & Del Rosso, M. (1998). Antisense targeting of the urokinase receptor blocks urokinase-dependent proliferation, chemoinvasion, and chemotaxis of human synovial cells and chondrocytes in vitro. Proceedings of the Association of American Physicians, 110(4), 340-50.
Fibbi G, et al. Antisense Targeting of the Urokinase Receptor Blocks Urokinase-dependent Proliferation, Chemoinvasion, and Chemotaxis of Human Synovial Cells and Chondrocytes in Vitro. Proc Assoc Am Physicians. 1998 Jul-Aug;110(4):340-50. PubMed PMID: 9686682.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antisense targeting of the urokinase receptor blocks urokinase-dependent proliferation, chemoinvasion, and chemotaxis of human synovial cells and chondrocytes in vitro. AU - Fibbi,G, AU - Pucci,M, AU - Serni,U, AU - Cerinic,M M, AU - Del Rosso,M, PY - 1998/8/1/pubmed PY - 1998/8/1/medline PY - 1998/8/1/entrez SP - 340 EP - 50 JF - Proceedings of the Association of American Physicians JO - Proc Assoc Am Physicians VL - 110 IS - 4 N2 - Proliferation and invasion of synovial pannus in rheumatoid arthritis and cartilage remodeling in osteoarthritis are key events in development of disability of arthritic joints. The mechanisms that trigger these events are still poorly understood. The production of urokinase-type plasminogen activator (u-PA) by synovial cells and chondrocytes and the subsequent interaction of u-PA with its membrane receptor (u-PAR) is under the control of a variety of growth factors and cytokines released within the inflamed joints. Here we show that u-PA, on interaction with the specific receptor, regulates movement and invasion as well as proliferation of human synovial cells and chondrocytes. Targeting the urokinase receptor with an antisense oligonucleotide blocks the u-PA-dependent synoviocyte and chondrocyte proliferation and chemoinvasion, suggesting a possible use for this new class of drugs in the progression of the disease in rheumatoid arthritis and osteoarthritis. SN - 1081-650X UR - https://www.unboundmedicine.com/medline/citation/9686682/Antisense_targeting_of_the_urokinase_receptor_blocks_urokinase_dependent_proliferation_chemoinvasion_and_chemotaxis_of_human_synovial_cells_and_chondrocytes_in_vitro_ DB - PRIME DP - Unbound Medicine ER -