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[The effect of carbamazepine on the content of monoamines and their metabolites in the brain structures of rats with audiogenic epilepsy].
Eksp Klin Farmakol. 1998 May-Jun; 61(3):25-7.EK

Abstract

It was shown that the content of serotonin (5-OT) and 5-oxyindoleacetic acid (5-OIAA) in the temporal cortex, hippocampus and medulla oblongata and the content of dopamine and 3,4-dihydroxyphenilacetic acid in the striatum are increased initially, while the level of norepinephrine in the striatum is reduced in Krushinskiĭ-Molodkina rats genetically predisposed to audiogenic epilepsy in comparison with Wistar rats. Carbamazepine levelled out the changes in the 5-OT and 5-OIAA levels at the peak of the audiogenic attack in the temporal cortex and hippocampus, causing at the same time a sum increase in the content of all monoamines and their metabolites in the medulla oblongata and striatum.

Authors+Show Affiliations

Kosacheva ES
Laboratory of Neurochemical Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Kudrin VS
No affiliation info available
Fedotova IB
No affiliation info available
Semiokhina AF
No affiliation info available
Raevskiĭ KS
No affiliation info available

MeSH

Acoustic StimulationAnimalsAnticonvulsantsBiogenic MonoaminesBrainBrain ChemistryCarbamazepineDose-Response Relationship, DrugEpilepsyMaleRatsRats, Inbred StrainsRats, WistarSeizures

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

rus

PubMed ID

9690071

Citation

Kosacheva, E S., et al. "[The Effect of Carbamazepine On the Content of Monoamines and Their Metabolites in the Brain Structures of Rats With Audiogenic Epilepsy]." Eksperimental'naia I Klinicheskaia Farmakologiia, vol. 61, no. 3, 1998, pp. 25-7.
Kosacheva ES, Kudrin VS, Fedotova IB, et al. [The effect of carbamazepine on the content of monoamines and their metabolites in the brain structures of rats with audiogenic epilepsy]. Eksp Klin Farmakol. 1998;61(3):25-7.
Kosacheva, E. S., Kudrin, V. S., Fedotova, I. B., Semiokhina, A. F., & Raevskiĭ, K. S. (1998). [The effect of carbamazepine on the content of monoamines and their metabolites in the brain structures of rats with audiogenic epilepsy]. Eksperimental'naia I Klinicheskaia Farmakologiia, 61(3), 25-7.
Kosacheva ES, et al. [The Effect of Carbamazepine On the Content of Monoamines and Their Metabolites in the Brain Structures of Rats With Audiogenic Epilepsy]. Eksp Klin Farmakol. 1998 May-Jun;61(3):25-7. PubMed PMID: 9690071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effect of carbamazepine on the content of monoamines and their metabolites in the brain structures of rats with audiogenic epilepsy]. AU - Kosacheva,E S, AU - Kudrin,V S, AU - Fedotova,I B, AU - Semiokhina,A F, AU - Raevskiĭ,K S, PY - 1998/8/5/pubmed PY - 1998/8/5/medline PY - 1998/8/5/entrez SP - 25 EP - 7 JF - Eksperimental'naia i klinicheskaia farmakologiia JO - Eksp Klin Farmakol VL - 61 IS - 3 N2 - It was shown that the content of serotonin (5-OT) and 5-oxyindoleacetic acid (5-OIAA) in the temporal cortex, hippocampus and medulla oblongata and the content of dopamine and 3,4-dihydroxyphenilacetic acid in the striatum are increased initially, while the level of norepinephrine in the striatum is reduced in Krushinskiĭ-Molodkina rats genetically predisposed to audiogenic epilepsy in comparison with Wistar rats. Carbamazepine levelled out the changes in the 5-OT and 5-OIAA levels at the peak of the audiogenic attack in the temporal cortex and hippocampus, causing at the same time a sum increase in the content of all monoamines and their metabolites in the medulla oblongata and striatum. SN - 0869-2092 UR - https://www.unboundmedicine.com/medline/citation/9690071/[The_effect_of_carbamazepine_on_the_content_of_monoamines_and_their_metabolites_in_the_brain_structures_of_rats_with_audiogenic_epilepsy]_ L2 - https://medlineplus.gov/seizures.html DB - PRIME DP - Unbound Medicine ER -