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Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid.
Prostaglandins Leukot Essent Fatty Acids. 1998 May; 58(5):353-64.PL

Abstract

Three diets containing either borage oil (BO) and southern hemisphere fish oil Marinol (MO), or BO and tuna orbital oil (TO), or a northern hemisphere fish oil (FO) were fed to duplicate groups of turbot (Scophthalmus maximus) of initial mean weight 1.2 g for a period of 12 weeks. The BO/MO and BO/TO diets were enriched in gamma-linolenic (18:3n-6, GLA) and eicosapentaenoic (20:5n-3, EPA) acids, and GLA and docosahexaenoic acid (22:6n-3, DHA), respectively. No differences were observed in final weights or growth rates, either between duplicate tanks or between dietary treatments. Half of the FO-fed fish sampled showed a histopathological lesion indicative of lipoid liver degeneration while the other treatments only showed a slight incidence of the same pathology. The fatty acid compositions of carcass and tissues broadly reflected the dietary input. In general, fish fed the BO/MO diet had increased levels of 18:2n-6, 18:3n-6, 20:3n-6 and 20:5n-3, but a lower level of 22:6n-3, compared to fish fed FO. In fish fed the BO/TO diet, levels of 18:2n-6, 18:3n-6, 20:3n-6 and 20:4n-6 were increased while levels of 20:5n-3 and 22:5n-3 were reduced, compared to fish fed FO. Concentrations of thromboxanes B (TXB) and leukotrienes B (LTB), derived from 20:4n-6 and 20:5n-3, were measured in plasma and stimulated blood cells. Levels of TXB2 were greatest in fish fed the BO/TO diet compared to both other treatments, while LTB4 was decreased in fish fed the BO/MO diet compared to both other treatments. In a stress test which involved anaesthesia followed by measurement of recovery times, fish fed the BO/MO diet had significantly lower recovery times compared to fish fed the FO diet.

Authors+Show Affiliations

Department of Biological and Molecular Sciences, University of Stirling, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9690713

Citation

Bell, J G., et al. "Growth, Mortality, Tissue Histopathology and Fatty Acid Compositions, Eicosanoid Production and Response to Stress, in Juvenile Turbot Fed Diets Rich in Gamma-linolenic Acid in Combination With Eicosapentaenoic Acid or Docosahexaenoic Acid." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 58, no. 5, 1998, pp. 353-64.
Bell JG, Tocher DR, Farndale BM, et al. Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. Prostaglandins Leukot Essent Fatty Acids. 1998;58(5):353-64.
Bell, J. G., Tocher, D. R., Farndale, B. M., & Sargent, J. R. (1998). Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 58(5), 353-64.
Bell JG, et al. Growth, Mortality, Tissue Histopathology and Fatty Acid Compositions, Eicosanoid Production and Response to Stress, in Juvenile Turbot Fed Diets Rich in Gamma-linolenic Acid in Combination With Eicosapentaenoic Acid or Docosahexaenoic Acid. Prostaglandins Leukot Essent Fatty Acids. 1998;58(5):353-64. PubMed PMID: 9690713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. AU - Bell,J G, AU - Tocher,D R, AU - Farndale,B M, AU - Sargent,J R, PY - 1998/8/5/pubmed PY - 1998/8/5/medline PY - 1998/8/5/entrez SP - 353 EP - 64 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 58 IS - 5 N2 - Three diets containing either borage oil (BO) and southern hemisphere fish oil Marinol (MO), or BO and tuna orbital oil (TO), or a northern hemisphere fish oil (FO) were fed to duplicate groups of turbot (Scophthalmus maximus) of initial mean weight 1.2 g for a period of 12 weeks. The BO/MO and BO/TO diets were enriched in gamma-linolenic (18:3n-6, GLA) and eicosapentaenoic (20:5n-3, EPA) acids, and GLA and docosahexaenoic acid (22:6n-3, DHA), respectively. No differences were observed in final weights or growth rates, either between duplicate tanks or between dietary treatments. Half of the FO-fed fish sampled showed a histopathological lesion indicative of lipoid liver degeneration while the other treatments only showed a slight incidence of the same pathology. The fatty acid compositions of carcass and tissues broadly reflected the dietary input. In general, fish fed the BO/MO diet had increased levels of 18:2n-6, 18:3n-6, 20:3n-6 and 20:5n-3, but a lower level of 22:6n-3, compared to fish fed FO. In fish fed the BO/TO diet, levels of 18:2n-6, 18:3n-6, 20:3n-6 and 20:4n-6 were increased while levels of 20:5n-3 and 22:5n-3 were reduced, compared to fish fed FO. Concentrations of thromboxanes B (TXB) and leukotrienes B (LTB), derived from 20:4n-6 and 20:5n-3, were measured in plasma and stimulated blood cells. Levels of TXB2 were greatest in fish fed the BO/TO diet compared to both other treatments, while LTB4 was decreased in fish fed the BO/MO diet compared to both other treatments. In a stress test which involved anaesthesia followed by measurement of recovery times, fish fed the BO/MO diet had significantly lower recovery times compared to fish fed the FO diet. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/9690713/Growth_mortality_tissue_histopathology_and_fatty_acid_compositions_eicosanoid_production_and_response_to_stress_in_juvenile_turbot_fed_diets_rich_in_gamma_linolenic_acid_in_combination_with_eicosapentaenoic_acid_or_docosahexaenoic_acid_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(98)90071-0 DB - PRIME DP - Unbound Medicine ER -