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Rehydration following exercise: effects of administration of water versus an isotonic oral rehydration solution (ORS).
Vet J. 1998 Jul; 156(1):41-9.VJ

Abstract

The effects of administering (1) 6L isotonic oral rehydration solution (ORS), similar in composition to plasma (except for an elevated potassium concentration) and with an osmotic skeleton and (2) 6L water (no osmotic skeleton), were evaluated in five thoroughbred horses following exercise-induced dehydration. The horses were exercised on a treadmill for 10 min at walk (1.7 m.s-1; approximately 15% VO2max), 40 min at trot (3.7 m.s-1; approximately 25% VO2max) and 10 min at walk (1.7 m.s-1; approximately 15% VO2max). Exercise was undertaken on a 3 degrees incline at 30 degrees C/80% RH. Solutions of water or ORS at 20 degrees C were administered by nasogastric tube over 60s 5 min following exercise. Mean weight loss following exercise was 9.2 +/- 1.7 kg (2.0 +/- 0.4% body weight; mean +/- SEM) with water and 9.2 +/- 1.1 kg (2.0 +/- 0.2% body weight) with ORS and was not different between treatments (P > 0.05). Water treatment resulted in a fall in plasma [Na+] (approximately 3 mmol.L-1) and C1- (1-2 mmol.L-1) concentrations by 30 min after administration and the effect persisted until the end of the study (300 min post fluids). There was little change in plasma total protein (TP) from that at the end of exercise, suggesting a failure of water to restore or maintain PV. In contrast, ORS administration resulted in a small increase in plasma [Na+] (1-2 mmol.L-1) and [Cl-] (2-3 mmol.L-1) with a corresponding decrease in plasma TP. By 120 min post ORS, plasma TP and PV were no longer significantly different from rest or pre-exercise (P > 0.05), whilst with water, TP was elevated (approximately 3-4 g.L-1) and PV reduced (approximately 4-5 mL.kg-1). Total urine output was not significantly different between water (1096 +/- 135 mL) and ORS (750 +/- 215 mL, P > 0.05). Estimates of expected plasma volume and electrolyte concentration changes as a result of either treatment compared well with measured changes of TP and PV. On the basis of calculated or measured changes, it was estimated that only 1L of water contributed to rehydration following exercise compared to 4L isotonic, plasma-like ORS. The administration of 6L ORS restored the PV deficit induced by exercise with minimal or no disturbance of plasma electrolyte concentrations. In contrast, water alone resulted in minimal improvement in PV. When fluid intake after periods of fluid loss, such as induced by exercise or transport, is not accompanied by food intake, the present study has clearly demonstrated that water alone is ineffective in promoting rehydration compared with an isotonic, plasma-like ORS.

Authors+Show Affiliations

Marlin DJ
Centre for Equine Studies, Animal Health Trust, Kentford, Newmarket, Suffolk, UK.
Scott CM
No affiliation info available
Mills PC
No affiliation info available
Louwes H
No affiliation info available
Vaarten J
No affiliation info available

MeSH

AnimalsBlood Chemical AnalysisDehydrationFluid TherapyHorse DiseasesHorsesMalePhysical Conditioning, AnimalTransportationWaterWater-Electrolyte Balance

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9691850

Citation

Marlin, D J., et al. "Rehydration Following Exercise: Effects of Administration of Water Versus an Isotonic Oral Rehydration Solution (ORS)." Veterinary Journal (London, England : 1997), vol. 156, no. 1, 1998, pp. 41-9.
Marlin DJ, Scott CM, Mills PC, et al. Rehydration following exercise: effects of administration of water versus an isotonic oral rehydration solution (ORS). Vet J. 1998;156(1):41-9.
Marlin, D. J., Scott, C. M., Mills, P. C., Louwes, H., & Vaarten, J. (1998). Rehydration following exercise: effects of administration of water versus an isotonic oral rehydration solution (ORS). Veterinary Journal (London, England : 1997), 156(1), 41-9.
Marlin DJ, et al. Rehydration Following Exercise: Effects of Administration of Water Versus an Isotonic Oral Rehydration Solution (ORS). Vet J. 1998;156(1):41-9. PubMed PMID: 9691850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rehydration following exercise: effects of administration of water versus an isotonic oral rehydration solution (ORS). AU - Marlin,D J, AU - Scott,C M, AU - Mills,P C, AU - Louwes,H, AU - Vaarten,J, PY - 1998/8/6/pubmed PY - 1998/8/6/medline PY - 1998/8/6/entrez SP - 41 EP - 9 JF - Veterinary journal (London, England : 1997) JO - Vet J VL - 156 IS - 1 N2 - The effects of administering (1) 6L isotonic oral rehydration solution (ORS), similar in composition to plasma (except for an elevated potassium concentration) and with an osmotic skeleton and (2) 6L water (no osmotic skeleton), were evaluated in five thoroughbred horses following exercise-induced dehydration. The horses were exercised on a treadmill for 10 min at walk (1.7 m.s-1; approximately 15% VO2max), 40 min at trot (3.7 m.s-1; approximately 25% VO2max) and 10 min at walk (1.7 m.s-1; approximately 15% VO2max). Exercise was undertaken on a 3 degrees incline at 30 degrees C/80% RH. Solutions of water or ORS at 20 degrees C were administered by nasogastric tube over 60s 5 min following exercise. Mean weight loss following exercise was 9.2 +/- 1.7 kg (2.0 +/- 0.4% body weight; mean +/- SEM) with water and 9.2 +/- 1.1 kg (2.0 +/- 0.2% body weight) with ORS and was not different between treatments (P > 0.05). Water treatment resulted in a fall in plasma [Na+] (approximately 3 mmol.L-1) and C1- (1-2 mmol.L-1) concentrations by 30 min after administration and the effect persisted until the end of the study (300 min post fluids). There was little change in plasma total protein (TP) from that at the end of exercise, suggesting a failure of water to restore or maintain PV. In contrast, ORS administration resulted in a small increase in plasma [Na+] (1-2 mmol.L-1) and [Cl-] (2-3 mmol.L-1) with a corresponding decrease in plasma TP. By 120 min post ORS, plasma TP and PV were no longer significantly different from rest or pre-exercise (P > 0.05), whilst with water, TP was elevated (approximately 3-4 g.L-1) and PV reduced (approximately 4-5 mL.kg-1). Total urine output was not significantly different between water (1096 +/- 135 mL) and ORS (750 +/- 215 mL, P > 0.05). Estimates of expected plasma volume and electrolyte concentration changes as a result of either treatment compared well with measured changes of TP and PV. On the basis of calculated or measured changes, it was estimated that only 1L of water contributed to rehydration following exercise compared to 4L isotonic, plasma-like ORS. The administration of 6L ORS restored the PV deficit induced by exercise with minimal or no disturbance of plasma electrolyte concentrations. In contrast, water alone resulted in minimal improvement in PV. When fluid intake after periods of fluid loss, such as induced by exercise or transport, is not accompanied by food intake, the present study has clearly demonstrated that water alone is ineffective in promoting rehydration compared with an isotonic, plasma-like ORS. SN - 1090-0233 UR - https://www.unboundmedicine.com/medline/citation/9691850/Rehydration_following_exercise:_effects_of_administration_of_water_versus_an_isotonic_oral_rehydration_solution__ORS__ L2 - https://medlineplus.gov/dehydration.html DB - PRIME DP - Unbound Medicine ER -