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Warfarin sensitivity after mechanical heart valve replacement.
Pharmacotherapy. 1998 Jul-Aug; 18(4):856-9.P

Abstract

We performed a retrospective chart review of 60 patients after mechanical heart valve replacement to assess warfarin sensitivity. The overall international normalized ratio (INR) on day 3 of therapy was 4.1+/-3.9 (range 1.1-17.1). In a control group of 100 patients who received anticoagulation for atrial fibrillation, pulmonary embolism, and deep vein thrombosis, the overall mean INR at day 3 was 1.9+/-0.7 (range 1.0-4.9). The difference between groups was statistically significant (p<0.05). We conclude that patients receiving warfarin after mechanical heart valve replacement are more sensitive to the drug than those receiving it for other indications, and reduced dosages may be necessary during the first 3 days after valve replacement.

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Authors+Show Affiliations

Rose JP
Department of Pharmacy, Allegheny University Hospitals, Allegheny General, Pittsburgh, Pennsylvania, USA.
Rihn TL
No affiliation info available
Long SF
No affiliation info available

MeSH

AdultAgedAged, 80 and overAnalysis of VarianceAnticoagulantsDose-Response Relationship, DrugFemaleHeart Valve Prosthesis ImplantationHumansInternational Normalized RatioMaleMiddle AgedProthrombin TimeRetrospective StudiesWarfarin

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9692661

Citation

Rose, J P., et al. "Warfarin Sensitivity After Mechanical Heart Valve Replacement." Pharmacotherapy, vol. 18, no. 4, 1998, pp. 856-9.
Rose JP, Rihn TL, Long SF. Warfarin sensitivity after mechanical heart valve replacement. Pharmacotherapy. 1998;18(4):856-9.
Rose, J. P., Rihn, T. L., & Long, S. F. (1998). Warfarin sensitivity after mechanical heart valve replacement. Pharmacotherapy, 18(4), 856-9.
Rose JP, Rihn TL, Long SF. Warfarin Sensitivity After Mechanical Heart Valve Replacement. Pharmacotherapy. 1998 Jul-Aug;18(4):856-9. PubMed PMID: 9692661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Warfarin sensitivity after mechanical heart valve replacement. AU - Rose,J P, AU - Rihn,T L, AU - Long,S F, PY - 1998/8/6/pubmed PY - 1998/8/6/medline PY - 1998/8/6/entrez SP - 856 EP - 9 JF - Pharmacotherapy JO - Pharmacotherapy VL - 18 IS - 4 N2 - We performed a retrospective chart review of 60 patients after mechanical heart valve replacement to assess warfarin sensitivity. The overall international normalized ratio (INR) on day 3 of therapy was 4.1+/-3.9 (range 1.1-17.1). In a control group of 100 patients who received anticoagulation for atrial fibrillation, pulmonary embolism, and deep vein thrombosis, the overall mean INR at day 3 was 1.9+/-0.7 (range 1.0-4.9). The difference between groups was statistically significant (p<0.05). We conclude that patients receiving warfarin after mechanical heart valve replacement are more sensitive to the drug than those receiving it for other indications, and reduced dosages may be necessary during the first 3 days after valve replacement. SN - 0277-0008 UR - https://www.unboundmedicine.com/medline/citation/9692661/Warfarin_sensitivity_after_mechanical_heart_valve_replacement_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0277-0008&amp;date=1998&amp;volume=18&amp;issue=4&amp;spage=856 DB - PRIME DP - Unbound Medicine ER -