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Omeprazole is more effective than cimetidine in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis.
Aliment Pharmacol Ther. 1998 Jan; 12(1):41-7.AP

Abstract

BACKGROUND

There is documentation of the long-term use of omeprazole 10 mg o.d. in patients with reflux oesophagitis but not in the large number of gastrooesophageal reflux disease (GERD) patients without oesophagitis. There is also a paucity of data on the long-term use of cimetidine in GERD patients.

METHODS

One hundred and fifty-six patients (100 male) who previously had symptomatic non-ulcerative oesophagitis (81%) or symptoms without oesophagitis (19%), were recruited. All patients were in symptomatic remission following 4 weeks of omeprazole 20 mg o.d. or cimetidine 400 mg q.d.s. and, if required, a further 4 weeks of omeprazole 20 mg o.d. Patients were randomized to receive, double-blind, either omeprazole 10 mg o.m. (n = 77) or cimetidine 800 mg nocte (n = 79) for 24 weeks.

RESULTS

A greater proportion of patients receiving omeprazole, compared with cimetidine, were in symptomatic remission after 12 (69 vs. 27%) and 24 weeks (60 vs. 24%) (each P < 0.0001). The median time to symptomatic relapse was longer for patients receiving omeprazole (169 vs. 15 days) (P = 0.0001). Of patients leaving the study in symptomatic remission, a greater proportion receiving omeprazole, compared with cimetidine, was free of oesophagitis (84 vs. 53%) (P < 0.05).

CONCLUSION

Omeprazole 10 mg o.m. is more effective than cimetidine 800 mg nocte in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis.

Authors+Show Affiliations

Royal Albert Edward Infirmary, Wigan, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9692699

Citation

Bate, C M., et al. "Omeprazole Is More Effective Than Cimetidine in the Prevention of Recurrence of GERD-associated Heartburn and the Occurrence of Underlying Oesophagitis." Alimentary Pharmacology & Therapeutics, vol. 12, no. 1, 1998, pp. 41-7.
Bate CM, Green JR, Axon AT, et al. Omeprazole is more effective than cimetidine in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis. Aliment Pharmacol Ther. 1998;12(1):41-7.
Bate, C. M., Green, J. R., Axon, A. T., Tildesley, G., Murrays, F. E., Owen, S. M., Emmas, C., & Taylor, M. D. (1998). Omeprazole is more effective than cimetidine in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis. Alimentary Pharmacology & Therapeutics, 12(1), 41-7.
Bate CM, et al. Omeprazole Is More Effective Than Cimetidine in the Prevention of Recurrence of GERD-associated Heartburn and the Occurrence of Underlying Oesophagitis. Aliment Pharmacol Ther. 1998;12(1):41-7. PubMed PMID: 9692699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omeprazole is more effective than cimetidine in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis. AU - Bate,C M, AU - Green,J R, AU - Axon,A T, AU - Tildesley,G, AU - Murrays,F E, AU - Owen,S M, AU - Emmas,C, AU - Taylor,M D, PY - 1998/8/6/pubmed PY - 1998/8/6/medline PY - 1998/8/6/entrez SP - 41 EP - 7 JF - Alimentary pharmacology & therapeutics JO - Aliment Pharmacol Ther VL - 12 IS - 1 N2 - BACKGROUND: There is documentation of the long-term use of omeprazole 10 mg o.d. in patients with reflux oesophagitis but not in the large number of gastrooesophageal reflux disease (GERD) patients without oesophagitis. There is also a paucity of data on the long-term use of cimetidine in GERD patients. METHODS: One hundred and fifty-six patients (100 male) who previously had symptomatic non-ulcerative oesophagitis (81%) or symptoms without oesophagitis (19%), were recruited. All patients were in symptomatic remission following 4 weeks of omeprazole 20 mg o.d. or cimetidine 400 mg q.d.s. and, if required, a further 4 weeks of omeprazole 20 mg o.d. Patients were randomized to receive, double-blind, either omeprazole 10 mg o.m. (n = 77) or cimetidine 800 mg nocte (n = 79) for 24 weeks. RESULTS: A greater proportion of patients receiving omeprazole, compared with cimetidine, were in symptomatic remission after 12 (69 vs. 27%) and 24 weeks (60 vs. 24%) (each P < 0.0001). The median time to symptomatic relapse was longer for patients receiving omeprazole (169 vs. 15 days) (P = 0.0001). Of patients leaving the study in symptomatic remission, a greater proportion receiving omeprazole, compared with cimetidine, was free of oesophagitis (84 vs. 53%) (P < 0.05). CONCLUSION: Omeprazole 10 mg o.m. is more effective than cimetidine 800 mg nocte in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/9692699/Omeprazole_is_more_effective_than_cimetidine_in_the_prevention_of_recurrence_of_GERD_associated_heartburn_and_the_occurrence_of_underlying_oesophagitis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0269-2813&amp;date=1998&amp;volume=12&amp;issue=1&amp;spage=41 DB - PRIME DP - Unbound Medicine ER -