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Effect of pseudoephedrine on nasal airflow in patients with nasal congestion associated with common cold.

Abstract

The aim of this study was to investigate the efficacy of pseudoephedrine as a nasal decongestant. Patients with nasal congestion associated with common cold received two doses of medication separated by 4 hours, either 60 mg pseudoephedrine (n = 20), or placebo (n = 20). Unilateral nasal airflow was measured over a 7-hour period to record the spontaneous changes in nasal airflow associated with the nasal cycle. Minimum (F MIN) and maximum (F MAX) unilateral nasal airflows were defined as the minimum and maximum nasal airflow values for each nasal passage recorded during the 7-hour period of the study. There was no significant difference in F MAX between the two treatment groups yet there was a significant difference in F MIN (p < 0.05). No difference in total nasal airflow (TNAF) between treatment groups was found, either before or after treatment (p > 0.05). The results demonstrate that (TNAF) is not as sensitive a measure of decongestion as F MIN. The findings of this study show that pseudoephedrine had no effect on the decongestion phase of the nasal cycle, but did significantly limit the congestion phase. The decongestant action may be explained by the sympathomimetic supplementing the natural sympathetic nervous activity to the nasal blood vessels.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Common Cold Centre, Cardiff University, Wales, United Kingdom.

    Source

    Rhinology 36:2 1998 Jun pg 73-6

    MeSH

    Adolescent
    Adult
    Airway Resistance
    Common Cold
    Ephedrine
    Female
    Humans
    Male
    Nasal Cavity
    Nasal Decongestants
    Nasal Obstruction
    Sympathomimetics
    Treatment Outcome

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    9695162

    Citation

    Jawad, S S., and R Eccles. "Effect of Pseudoephedrine On Nasal Airflow in Patients With Nasal Congestion Associated With Common Cold." Rhinology, vol. 36, no. 2, 1998, pp. 73-6.
    Jawad SS, Eccles R. Effect of pseudoephedrine on nasal airflow in patients with nasal congestion associated with common cold. Rhinology. 1998;36(2):73-6.
    Jawad, S. S., & Eccles, R. (1998). Effect of pseudoephedrine on nasal airflow in patients with nasal congestion associated with common cold. Rhinology, 36(2), pp. 73-6.
    Jawad SS, Eccles R. Effect of Pseudoephedrine On Nasal Airflow in Patients With Nasal Congestion Associated With Common Cold. Rhinology. 1998;36(2):73-6. PubMed PMID: 9695162.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of pseudoephedrine on nasal airflow in patients with nasal congestion associated with common cold. AU - Jawad,S S, AU - Eccles,R, PY - 1998/8/8/pubmed PY - 1998/8/8/medline PY - 1998/8/8/entrez SP - 73 EP - 6 JF - Rhinology JO - Rhinology VL - 36 IS - 2 N2 - The aim of this study was to investigate the efficacy of pseudoephedrine as a nasal decongestant. Patients with nasal congestion associated with common cold received two doses of medication separated by 4 hours, either 60 mg pseudoephedrine (n = 20), or placebo (n = 20). Unilateral nasal airflow was measured over a 7-hour period to record the spontaneous changes in nasal airflow associated with the nasal cycle. Minimum (F MIN) and maximum (F MAX) unilateral nasal airflows were defined as the minimum and maximum nasal airflow values for each nasal passage recorded during the 7-hour period of the study. There was no significant difference in F MAX between the two treatment groups yet there was a significant difference in F MIN (p < 0.05). No difference in total nasal airflow (TNAF) between treatment groups was found, either before or after treatment (p > 0.05). The results demonstrate that (TNAF) is not as sensitive a measure of decongestion as F MIN. The findings of this study show that pseudoephedrine had no effect on the decongestion phase of the nasal cycle, but did significantly limit the congestion phase. The decongestant action may be explained by the sympathomimetic supplementing the natural sympathetic nervous activity to the nasal blood vessels. SN - 0300-0729 UR - https://www.unboundmedicine.com/medline/citation/9695162/Effect_of_pseudoephedrine_on_nasal_airflow_in_patients_with_nasal_congestion_associated_with_common_cold_ L2 - http://www.rhinologyjournal.com/Abstract.php?id=201 DB - PRIME DP - Unbound Medicine ER -