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CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor.
Semin Immunol. 1998 Aug; 10(4):287-97.SI

Abstract

The CD22 cell-surface adhesion molecule is capable of modulating B lymphocyte antigen receptor (BCR)-mediated signals, as well as the generation of BCR-independent signals. Within the cytoplasmic domain of CD22 are motifs that are structurally homologous to known activation and inhibitory motifs. These motifs demonstrate physiologic significance via associations with known effector proteins that likely mediate their corresponding inhibitory and activation roles. Furthermore, the targeted deletion of CD22 in mice results in phenotypic changes and alterations in BCR-mediated signal transduction that are consistent with both positive and negative roles for CD22 in B cell development and activation.

Authors+Show Affiliations

Department of Dermatology, Kanazawa University School of Medicine, Ishikawa, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

9695185

Citation

Sato, S, et al. "CD22 Negatively and Positively Regulates Signal Transduction Through the B Lymphocyte Antigen Receptor." Seminars in Immunology, vol. 10, no. 4, 1998, pp. 287-97.
Sato S, Tuscano JM, Inaoki M, et al. CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor. Semin Immunol. 1998;10(4):287-97.
Sato, S., Tuscano, J. M., Inaoki, M., & Tedder, T. F. (1998). CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor. Seminars in Immunology, 10(4), 287-97.
Sato S, et al. CD22 Negatively and Positively Regulates Signal Transduction Through the B Lymphocyte Antigen Receptor. Semin Immunol. 1998;10(4):287-97. PubMed PMID: 9695185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor. AU - Sato,S, AU - Tuscano,J M, AU - Inaoki,M, AU - Tedder,T F, PY - 1998/8/8/pubmed PY - 1998/8/8/medline PY - 1998/8/8/entrez SP - 287 EP - 97 JF - Seminars in immunology JO - Semin Immunol VL - 10 IS - 4 N2 - The CD22 cell-surface adhesion molecule is capable of modulating B lymphocyte antigen receptor (BCR)-mediated signals, as well as the generation of BCR-independent signals. Within the cytoplasmic domain of CD22 are motifs that are structurally homologous to known activation and inhibitory motifs. These motifs demonstrate physiologic significance via associations with known effector proteins that likely mediate their corresponding inhibitory and activation roles. Furthermore, the targeted deletion of CD22 in mice results in phenotypic changes and alterations in BCR-mediated signal transduction that are consistent with both positive and negative roles for CD22 in B cell development and activation. SN - 1044-5323 UR - https://www.unboundmedicine.com/medline/citation/9695185/CD22_negatively_and_positively_regulates_signal_transduction_through_the_B_lymphocyte_antigen_receptor_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1044-5323(98)90121-X DB - PRIME DP - Unbound Medicine ER -