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The additive effect of sclerotherapy to patients receiving repeated endoscopic variceal ligation: a prospective, randomized trial.
Hepatology. 1998 Aug; 28(2):391-5.Hep

Abstract

Endoscopic variceal ligation (EVL) is a new technique designed to manage esophageal varices. The effect of sclerotherapy following repeated banding ligation remains unknown. Seventy-two patients with a history of esophageal variceal bleeding received regular EVL until variceal disappearance or until left with residual small varices. Subsequently, patients were randomized to receive sclerotherapy (Group 1, 37 patients) or serve as a control (Group 2, 35 patients). Group 1 received one to two sessions of low-dose sclerotherapy to achieve complete variceal disappearance. After a mean follow-up of 2 years, 4 months, recurrent esophageal varices developed in 14% of Group 1 and 43% of Group 2 (P < .02). Rebleeding was encountered in 8% of Group 1 versus 31% of Group 2 (P = .01). One case of esophageal stricture (2.7%) was encountered in Group 1. One patient in Group 1, compared with 3 patients in Group 2, died of massive variceal bleeding (P > .05). The multivariate Cox model indicated that treatment was the only factor predictive of variceal recurrence, and both Child-Pugh class and treatment were factors predictive of variceal rebleeding. The addition of low-dose sclerotherapy following repeated banding ligations proved safe and effective in the prevention of recurrence of esophageal varices and rebleeding.

Authors+Show Affiliations

Division of Gastroenterology, Department of Medicine, Veterans General Hospital-Kaohsiung, National Yang-Ming University, Taipei, Taiwan, Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9696002

Citation

Lo, G H., et al. "The Additive Effect of Sclerotherapy to Patients Receiving Repeated Endoscopic Variceal Ligation: a Prospective, Randomized Trial." Hepatology (Baltimore, Md.), vol. 28, no. 2, 1998, pp. 391-5.
Lo GH, Lai KH, Cheng JS, et al. The additive effect of sclerotherapy to patients receiving repeated endoscopic variceal ligation: a prospective, randomized trial. Hepatology. 1998;28(2):391-5.
Lo, G. H., Lai, K. H., Cheng, J. S., Lin, C. K., Huang, J. S., Hsu, P. I., Huang, H. C., & Chiang, H. T. (1998). The additive effect of sclerotherapy to patients receiving repeated endoscopic variceal ligation: a prospective, randomized trial. Hepatology (Baltimore, Md.), 28(2), 391-5.
Lo GH, et al. The Additive Effect of Sclerotherapy to Patients Receiving Repeated Endoscopic Variceal Ligation: a Prospective, Randomized Trial. Hepatology. 1998;28(2):391-5. PubMed PMID: 9696002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The additive effect of sclerotherapy to patients receiving repeated endoscopic variceal ligation: a prospective, randomized trial. AU - Lo,G H, AU - Lai,K H, AU - Cheng,J S, AU - Lin,C K, AU - Huang,J S, AU - Hsu,P I, AU - Huang,H C, AU - Chiang,H T, PY - 1998/8/8/pubmed PY - 1998/8/8/medline PY - 1998/8/8/entrez SP - 391 EP - 5 JF - Hepatology (Baltimore, Md.) JO - Hepatology VL - 28 IS - 2 N2 - Endoscopic variceal ligation (EVL) is a new technique designed to manage esophageal varices. The effect of sclerotherapy following repeated banding ligation remains unknown. Seventy-two patients with a history of esophageal variceal bleeding received regular EVL until variceal disappearance or until left with residual small varices. Subsequently, patients were randomized to receive sclerotherapy (Group 1, 37 patients) or serve as a control (Group 2, 35 patients). Group 1 received one to two sessions of low-dose sclerotherapy to achieve complete variceal disappearance. After a mean follow-up of 2 years, 4 months, recurrent esophageal varices developed in 14% of Group 1 and 43% of Group 2 (P < .02). Rebleeding was encountered in 8% of Group 1 versus 31% of Group 2 (P = .01). One case of esophageal stricture (2.7%) was encountered in Group 1. One patient in Group 1, compared with 3 patients in Group 2, died of massive variceal bleeding (P > .05). The multivariate Cox model indicated that treatment was the only factor predictive of variceal recurrence, and both Child-Pugh class and treatment were factors predictive of variceal rebleeding. The addition of low-dose sclerotherapy following repeated banding ligations proved safe and effective in the prevention of recurrence of esophageal varices and rebleeding. SN - 0270-9139 UR - https://www.unboundmedicine.com/medline/citation/9696002/The_additive_effect_of_sclerotherapy_to_patients_receiving_repeated_endoscopic_variceal_ligation:_a_prospective_randomized_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0270913998003164 DB - PRIME DP - Unbound Medicine ER -