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Effect of medium- and long-chain triglycerides on lower esophageal sphincter pressure: role of CCK.
Am J Physiol. 1998 06; 274(6):G1160-5.AJ

Abstract

Fat meals are known to decrease lower esophageal sphincter (LES) pressure, possibly through postprandial CCK release. Dietary fat consists mainly of long-chain triglycerides (LCT), which potently stimulate CCK secretion. This effect contrasts with that of medium-chain triglycerides (MCT), which do not induce CCK release. We recorded LES pressure and gallbladder volume in six healthy subjects on five separate occasions during intraduodenal administration of 1) saline control, 2) LCT, 3) MCT, 4) LCT during intravenous infusion of the CCK receptor antagonist loxiglumide, and 5) MCT together with loxiglumide. LES pressure decreased significantly during administration of both LCT and MCT. Loxiglumide completely prevented the reduction in LES pressure during intraduodenal LCT, but not during intraduodenal MCT. Gallbladder volume decreased during LCT, but not during MCT. It is concluded that intraduodenal administration of equimolar amounts of both LCT and MCT significantly reduces LES pressure. The effect of LCT on LES pressure is mediated by CCK. The effect of MCT is not dependent on CCK, since MCT does not release CCK and loxiglumide does not prevent the MCT-induced reduction in LES pressure.

Authors+Show Affiliations

Department of Gastroenterology-Hepatology, Leiden University Medical Center, Leiden, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9696717

Citation

Ledeboer, M, et al. "Effect of Medium- and Long-chain Triglycerides On Lower Esophageal Sphincter Pressure: Role of CCK." The American Journal of Physiology, vol. 274, no. 6, 1998, pp. G1160-5.
Ledeboer M, Masclee AA, Biemond I, et al. Effect of medium- and long-chain triglycerides on lower esophageal sphincter pressure: role of CCK. Am J Physiol. 1998;274(6):G1160-5.
Ledeboer, M., Masclee, A. A., Biemond, I., & Lamers, C. B. (1998). Effect of medium- and long-chain triglycerides on lower esophageal sphincter pressure: role of CCK. The American Journal of Physiology, 274(6), G1160-5. https://doi.org/10.1152/ajpgi.1998.274.6.G1160
Ledeboer M, et al. Effect of Medium- and Long-chain Triglycerides On Lower Esophageal Sphincter Pressure: Role of CCK. Am J Physiol. 1998;274(6):G1160-5. PubMed PMID: 9696717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of medium- and long-chain triglycerides on lower esophageal sphincter pressure: role of CCK. AU - Ledeboer,M, AU - Masclee,A A, AU - Biemond,I, AU - Lamers,C B, PY - 1998/8/8/pubmed PY - 1998/8/8/medline PY - 1998/8/8/entrez SP - G1160 EP - 5 JF - The American journal of physiology JO - Am J Physiol VL - 274 IS - 6 N2 - Fat meals are known to decrease lower esophageal sphincter (LES) pressure, possibly through postprandial CCK release. Dietary fat consists mainly of long-chain triglycerides (LCT), which potently stimulate CCK secretion. This effect contrasts with that of medium-chain triglycerides (MCT), which do not induce CCK release. We recorded LES pressure and gallbladder volume in six healthy subjects on five separate occasions during intraduodenal administration of 1) saline control, 2) LCT, 3) MCT, 4) LCT during intravenous infusion of the CCK receptor antagonist loxiglumide, and 5) MCT together with loxiglumide. LES pressure decreased significantly during administration of both LCT and MCT. Loxiglumide completely prevented the reduction in LES pressure during intraduodenal LCT, but not during intraduodenal MCT. Gallbladder volume decreased during LCT, but not during MCT. It is concluded that intraduodenal administration of equimolar amounts of both LCT and MCT significantly reduces LES pressure. The effect of LCT on LES pressure is mediated by CCK. The effect of MCT is not dependent on CCK, since MCT does not release CCK and loxiglumide does not prevent the MCT-induced reduction in LES pressure. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/9696717/Effect_of_medium__and_long_chain_triglycerides_on_lower_esophageal_sphincter_pressure:_role_of_CCK_ L2 - https://journals.physiology.org/doi/10.1152/ajpgi.1998.274.6.G1160?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -