Abstract
OBJECTIVE
Inherited resistance to activated protein C (APC resistance), which is caused by a single point mutation in the factor V gene, is a frequent risk factor for venous thromboembolism. The aim of this study was to determine the prevalence of APC resistance and other coagulation disorders in fertile women with venous thromboembolism and also the risk factors these women had been exposed to in connection with thromboembolic events.
DESIGN
A retrospective, case-control study of 36 month duration.
SETTING
The study was carried out at Blekinge Hospital, Karlskrona, Sweden.
SUBJECTS
The study population comprised 27 fertile women age 16-47 years with thromboembolic complications, referred to the department of Internal Medicine at Blekinge Hospital in Karlskrona during a 36-month period.
RESULTS
APC resistance was found in 10 out of 27 women. APC resistance was associated with treatment with oral contraceptives in five out of six women and with pregnancy in one of seven women. All women with resistance to APC developed venous thrombosis in association with a predisposing situation (risk situation) such as surgery, trauma, immobilization, pregnancy, inflammatory state or the use of oral contraceptives. Amongst women not resistant to APC, all but one developed thrombosis in connection with a risk situation.
CONCLUSION
APC resistance was found to be highly prevalent amongst fertile women with a history of thromboembolic complication occurring during their use of oral contraceptives.
TY - JOUR
T1 - Resistance to activated protein C, highly prevalent amongst users of oral contraceptives with venous thromboembolism.
AU - Bennet,L,
AU - Odeberg,H,
PY - 1998/8/11/pubmed
PY - 1998/8/11/medline
PY - 1998/8/11/entrez
KW - Biology
KW - Blood Coagulation Effects
KW - Contraception
KW - Contraceptive Agents, Female--pharmacodynamics
KW - Contraceptive Agents, Progestin--pharmacodynamics
KW - Contraceptive Agents--pharmacodynamics
KW - Contraceptive Methods--side effects
KW - Desogestrel--pharmacodynamics
KW - Developed Countries
KW - Diseases
KW - Embolism
KW - Europe
KW - Family Planning
KW - Genetics
KW - Hematological Effects
KW - Hemic System
KW - Northern Europe
KW - Oral Contraceptives, Combined--side effects
KW - Oral Contraceptives--side effects
KW - Physiology
KW - Research Methodology
KW - Research Report
KW - Retrospective Studies
KW - Risk Factors
KW - Scandinavia
KW - Studies
KW - Sweden
KW - Thromboembolism
KW - Vascular Diseases
SP - 27
EP - 32
JF - Journal of internal medicine
JO - J Intern Med
VL - 244
IS - 1
N2 - OBJECTIVE: Inherited resistance to activated protein C (APC resistance), which is caused by a single point mutation in the factor V gene, is a frequent risk factor for venous thromboembolism. The aim of this study was to determine the prevalence of APC resistance and other coagulation disorders in fertile women with venous thromboembolism and also the risk factors these women had been exposed to in connection with thromboembolic events. DESIGN: A retrospective, case-control study of 36 month duration. SETTING: The study was carried out at Blekinge Hospital, Karlskrona, Sweden. SUBJECTS: The study population comprised 27 fertile women age 16-47 years with thromboembolic complications, referred to the department of Internal Medicine at Blekinge Hospital in Karlskrona during a 36-month period. RESULTS: APC resistance was found in 10 out of 27 women. APC resistance was associated with treatment with oral contraceptives in five out of six women and with pregnancy in one of seven women. All women with resistance to APC developed venous thrombosis in association with a predisposing situation (risk situation) such as surgery, trauma, immobilization, pregnancy, inflammatory state or the use of oral contraceptives. Amongst women not resistant to APC, all but one developed thrombosis in connection with a risk situation. CONCLUSION: APC resistance was found to be highly prevalent amongst fertile women with a history of thromboembolic complication occurring during their use of oral contraceptives.
SN - 0954-6820
UR - https://www.unboundmedicine.com/medline/citation/9698021/Resistance_to_activated_protein_C_highly_prevalent_amongst_users_of_oral_contraceptives_with_venous_thromboembolism_
L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-6820&date=1998&volume=244&issue=1&spage=27
DB - PRIME
DP - Unbound Medicine
ER -
