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Rates of change in spinal bone density among Japanese women.

Abstract

To determine the rates of change in bone mineral density (BMD) at the spine in healthy Japanese women, longitudinal measurements of spinal BMD using dual X-ray absorptiometry were collected from 984 women over 17 years of age (mean age 51.6) at eight medical research centers. They were followed up for 20.9 months on average without any treatment influencing bone and calcium metabolism. Measurements of BMD obtained by two different scanners were converted into standardized BMD (sBMD) values. The multiple linear regression model predicts that spinal sBMD increases up to about 23 years of age: the estimated average rates of increases were 0.13%/year for women aged 20 years. After the age of 23, the sBMD began decreasing: the rates of loss increased by 0.045%/year for each year increase in age among premenopausal women. In perimenopausal women, the rate of loss was 2. 1%/year. In postnatural menopausal women, the rates of loss decreased exponentially with increasing years since menopause. The rates of loss increased by 0.04%/year for 1 kg decrease in body weight or by 0.1%/year for 1 kg/m2 decrease in body mass index. No significant differences in changes in sBMD were found between scanners and between centers after multiple adjustment. We conclude that the rates of change in spinal sBMD are associated with age in premenopausal women, and with years since menopause and weight or BMI in postmenopausal women. Caution is needed, however, when using data from different densitometers to evaluate rates in bone loss in multicenter trials.

Authors+Show Affiliations

,

Department of Clinical Studies, Radiation Effects Research Foundation, 5-2 Hijiyama Park, Minami-Ku, Hiroshima, 732 Japan.

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Source

Calcified tissue international 63:3 1998 Sep pg 202-7

MeSH

Adolescent
Adult
Aged
Aging
Bone Density
Female
Humans
Japan
Menopause
Middle Aged
Osteoporosis
Postmenopause
Premenopause
Regression Analysis
Spine

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9701623

Citation

Fujiwara, S, et al. "Rates of Change in Spinal Bone Density Among Japanese Women." Calcified Tissue International, vol. 63, no. 3, 1998, pp. 202-7.
Fujiwara S, Fukunaga M, Nakamura T, et al. Rates of change in spinal bone density among Japanese women. Calcif Tissue Int. 1998;63(3):202-7.
Fujiwara, S., Fukunaga, M., Nakamura, T., Chen, J. T., Shiraki, M., Hashimoto, T., ... Orimo, H. (1998). Rates of change in spinal bone density among Japanese women. Calcified Tissue International, 63(3), pp. 202-7.
Fujiwara S, et al. Rates of Change in Spinal Bone Density Among Japanese Women. Calcif Tissue Int. 1998;63(3):202-7. PubMed PMID: 9701623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rates of change in spinal bone density among Japanese women. AU - Fujiwara,S, AU - Fukunaga,M, AU - Nakamura,T, AU - Chen,J T, AU - Shiraki,M, AU - Hashimoto,T, AU - Yoh,K, AU - Nakamura,T, AU - Mizunuma,H, AU - Tomomitsu,T, AU - Kasagi,F, AU - Masunari,N, AU - Orimo,H, PY - 1998/8/14/pubmed PY - 1998/8/14/medline PY - 1998/8/14/entrez SP - 202 EP - 7 JF - Calcified tissue international JO - Calcif. Tissue Int. VL - 63 IS - 3 N2 - To determine the rates of change in bone mineral density (BMD) at the spine in healthy Japanese women, longitudinal measurements of spinal BMD using dual X-ray absorptiometry were collected from 984 women over 17 years of age (mean age 51.6) at eight medical research centers. They were followed up for 20.9 months on average without any treatment influencing bone and calcium metabolism. Measurements of BMD obtained by two different scanners were converted into standardized BMD (sBMD) values. The multiple linear regression model predicts that spinal sBMD increases up to about 23 years of age: the estimated average rates of increases were 0.13%/year for women aged 20 years. After the age of 23, the sBMD began decreasing: the rates of loss increased by 0.045%/year for each year increase in age among premenopausal women. In perimenopausal women, the rate of loss was 2. 1%/year. In postnatural menopausal women, the rates of loss decreased exponentially with increasing years since menopause. The rates of loss increased by 0.04%/year for 1 kg decrease in body weight or by 0.1%/year for 1 kg/m2 decrease in body mass index. No significant differences in changes in sBMD were found between scanners and between centers after multiple adjustment. We conclude that the rates of change in spinal sBMD are associated with age in premenopausal women, and with years since menopause and weight or BMI in postmenopausal women. Caution is needed, however, when using data from different densitometers to evaluate rates in bone loss in multicenter trials. SN - 0171-967X UR - https://www.unboundmedicine.com/medline/citation/9701623/Rates_of_change_in_spinal_bone_density_among_Japanese_women_ L2 - https://medlineplus.gov/bonedensity.html DB - PRIME DP - Unbound Medicine ER -