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Apolipoprotein E genotypes in sporadic early and late-onset Alzheimer's disease.
Arch Immunol Ther Exp (Warsz). 1998; 46(3):177-81.AI

Abstract

Recent data have demonstrated that presence of apolipoprotein E (APOE) epsilon *4 allele is a major risk factor of Alzheimer's disease (AD). We determined the APOE genotypes in 64 patients with sporadic probable AD and 43 non-demented aged controls selected from Poznań region and the western part of Poland using the polymerase chain reaction (PCR) followed by the restriction fragment length polymorphism (RFLP) analysis. We confirmed a strong correlation of the APOE epsilon *4 allele with sporadic late-onset AD. In contrast to many previous reports we did not found an association between the APOE epsilon *4 allele and sporadic early-onset AD.

Authors+Show Affiliations

Institute of Human Genetics, Polish Academy of Sciences, Poznań, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9704150

Citation

Kowalska, A, et al. "Apolipoprotein E Genotypes in Sporadic Early and Late-onset Alzheimer's Disease." Archivum Immunologiae Et Therapiae Experimentalis, vol. 46, no. 3, 1998, pp. 177-81.
Kowalska A, Florczak J, Pruchnik-Wolińska D, et al. Apolipoprotein E genotypes in sporadic early and late-onset Alzheimer's disease. Arch Immunol Ther Exp (Warsz). 1998;46(3):177-81.
Kowalska, A., Florczak, J., Pruchnik-Wolińska, D., Kraszewski, A., & Wender, M. (1998). Apolipoprotein E genotypes in sporadic early and late-onset Alzheimer's disease. Archivum Immunologiae Et Therapiae Experimentalis, 46(3), 177-81.
Kowalska A, et al. Apolipoprotein E Genotypes in Sporadic Early and Late-onset Alzheimer's Disease. Arch Immunol Ther Exp (Warsz). 1998;46(3):177-81. PubMed PMID: 9704150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E genotypes in sporadic early and late-onset Alzheimer's disease. AU - Kowalska,A, AU - Florczak,J, AU - Pruchnik-Wolińska,D, AU - Kraszewski,A, AU - Wender,M, PY - 1998/8/15/pubmed PY - 1998/8/15/medline PY - 1998/8/15/entrez SP - 177 EP - 81 JF - Archivum immunologiae et therapiae experimentalis JO - Arch. Immunol. Ther. Exp. (Warsz.) VL - 46 IS - 3 N2 - Recent data have demonstrated that presence of apolipoprotein E (APOE) epsilon *4 allele is a major risk factor of Alzheimer's disease (AD). We determined the APOE genotypes in 64 patients with sporadic probable AD and 43 non-demented aged controls selected from Poznań region and the western part of Poland using the polymerase chain reaction (PCR) followed by the restriction fragment length polymorphism (RFLP) analysis. We confirmed a strong correlation of the APOE epsilon *4 allele with sporadic late-onset AD. In contrast to many previous reports we did not found an association between the APOE epsilon *4 allele and sporadic early-onset AD. SN - 0004-069X UR - https://www.unboundmedicine.com/medline/citation/9704150/Apolipoprotein_E_genotypes_in_sporadic_early_and_late_onset_Alzheimer's_disease_ L2 - https://medlineplus.gov/alzheimersdisease.html DB - PRIME DP - Unbound Medicine ER -