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Sudden coronary death in women.
Am Heart J. 1998 Aug; 136(2):205-12.AH

Abstract

OBJECTIVES

The objective of this study was to examine prospectively the incidence, predisposing cardiovascular conditions, and risk factors for sudden death in women compared with men.

METHODS AND RESULT

The study design was a prospective general population examination of a cohort of 2873 women for development of sudden coronary death in relation to antecedent overt coronary heart disease (CHD), cardiac failure, and risk factors for coronary heart disease. Participants were women aged 30 to 62 years participating in the Framingham Study, receiving routine biennial examinations for risk factors and cardiovascular conditions. Among women monitored over a period of 38 years, there were 750 initial coronary events, of which 94 (12%) were sudden cardiac deaths. Of the 292 CHD fatalities in women, 32% were sudden cardiac deaths and 37% of the women had a history of prior CHD. Sudden death incidence in women logged behind that in men by >10 years. However, above age 75 years, 17% of all CHD events in women were sudden deaths. Sudden death risk in women with CHD was half as high as in men if they had CHD. In both sexes, a myocardial infarction conferred twice the risk of angina. Cardiac failure escalated sudden death risk of women 5-fold but was only one fourth that of men with failure or CHD. Ventricular ectopy increased sudden death risk only in women without prior overt CHD. Except for diabetes, CHD risk factors imposed a lower sudden death risk in women than men. However, even in women, sudden death risk increased over a 17-fold range in relation to their burden of CHD risk factors.

CONCLUSIONS

Sudden death is a prominent feature of CHD in women as well as men, particularly in advanced age. A higher fraction of sudden deaths in women than men is unexpected occurring in the absence of prior overt CHD. It is subject to the same risk factors and as predictable in women as in men. However, at any level of multivariate risk, women are less vulnerable to sudden death than men.

Authors+Show Affiliations

Department of Medicine, Evans Memorial Research Foundation, Boston, Mass., USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9704680

Citation

Kannel, W B., et al. "Sudden Coronary Death in Women." American Heart Journal, vol. 136, no. 2, 1998, pp. 205-12.
Kannel WB, Wilson PW, D'Agostino RB, et al. Sudden coronary death in women. Am Heart J. 1998;136(2):205-12.
Kannel, W. B., Wilson, P. W., D'Agostino, R. B., & Cobb, J. (1998). Sudden coronary death in women. American Heart Journal, 136(2), 205-12.
Kannel WB, et al. Sudden Coronary Death in Women. Am Heart J. 1998;136(2):205-12. PubMed PMID: 9704680.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sudden coronary death in women. AU - Kannel,W B, AU - Wilson,P W, AU - D'Agostino,R B, AU - Cobb,J, PY - 1998/8/15/pubmed PY - 1998/8/15/medline PY - 1998/8/15/entrez SP - 205 EP - 12 JF - American heart journal JO - Am Heart J VL - 136 IS - 2 N2 - OBJECTIVES: The objective of this study was to examine prospectively the incidence, predisposing cardiovascular conditions, and risk factors for sudden death in women compared with men. METHODS AND RESULT: The study design was a prospective general population examination of a cohort of 2873 women for development of sudden coronary death in relation to antecedent overt coronary heart disease (CHD), cardiac failure, and risk factors for coronary heart disease. Participants were women aged 30 to 62 years participating in the Framingham Study, receiving routine biennial examinations for risk factors and cardiovascular conditions. Among women monitored over a period of 38 years, there were 750 initial coronary events, of which 94 (12%) were sudden cardiac deaths. Of the 292 CHD fatalities in women, 32% were sudden cardiac deaths and 37% of the women had a history of prior CHD. Sudden death incidence in women logged behind that in men by >10 years. However, above age 75 years, 17% of all CHD events in women were sudden deaths. Sudden death risk in women with CHD was half as high as in men if they had CHD. In both sexes, a myocardial infarction conferred twice the risk of angina. Cardiac failure escalated sudden death risk of women 5-fold but was only one fourth that of men with failure or CHD. Ventricular ectopy increased sudden death risk only in women without prior overt CHD. Except for diabetes, CHD risk factors imposed a lower sudden death risk in women than men. However, even in women, sudden death risk increased over a 17-fold range in relation to their burden of CHD risk factors. CONCLUSIONS: Sudden death is a prominent feature of CHD in women as well as men, particularly in advanced age. A higher fraction of sudden deaths in women than men is unexpected occurring in the absence of prior overt CHD. It is subject to the same risk factors and as predictable in women as in men. However, at any level of multivariate risk, women are less vulnerable to sudden death than men. SN - 0002-8703 UR - https://www.unboundmedicine.com/medline/citation/9704680/Sudden_coronary_death_in_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8703(98)00147-1 DB - PRIME DP - Unbound Medicine ER -