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Low-affinity kainate receptors and long-lasting depression of NMDA-receptor-mediated currents in rat superficial dorsal horn.
J Neurophysiol. 1998 Aug; 80(2):895-902.JN

Abstract

In an in vitro spinal cord slice preparation whole cell electrophysiological recordings of rat superficial dorsal horn neurons responding differentially to glutamate (Glu) and N-methyl-D-aspartate (NMDA) were investigated systematically for the role of kainate (KA) receptors in modulating their activity. In these neurons, coapplication of Glu and NMDA, as well as application of Glu immediately before NMDA, induced long- and short-lasting depressions of NMDA-induced currents as well as depression of NMDA-receptor-mediated excitatory postsynaptic currents. KA applied before NMDA mimicked Glu-induced attenuating effects. Furthermore, the low-affinity KA receptor antagonist 5-nitro-6,7,8,9- tetrahydrobenzo[G]indole-2,3-dione-3-oxime potentiated Glu-induced NMDA-receptor-mediated currents in neurons responding differentially to Glu and NMDA. These results provide evidence for a novel mechanism, which may relate to classical long-term depression, involving low-affinity KA receptors in long-lasting modulation of NMDA-receptor-mediated currents. This implies a physiological role of KA receptors in long-term modulation of sensory transmission in the superficial dorsal horn of rat spinal cord.

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Authors+Show Affiliations

Sequeira S
Department of Cellular and Molecular Pharmacology, Discovery Division, Astra Pain Control AB, S-141 57 Huddinge, Sweden.
Näsström J
No affiliation info available

MeSH

Action PotentialsAnimalsCalciumCycloleucineElectrophysiologyExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsGanglia, SpinalGlutamic AcidIndolesIon Channel GatingKainic AcidMaleN-MethylaspartateNeurons, AfferentNeuroprotective AgentsOximesQuinoxalinesRatsRats, Sprague-DawleyReceptors, Kainic AcidReceptors, N-Methyl-D-AspartateSpinal CordSpinal Nerve RootsSynaptic Transmission

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9705476

Citation

Sequeira, S, and J Näsström. "Low-affinity Kainate Receptors and Long-lasting Depression of NMDA-receptor-mediated Currents in Rat Superficial Dorsal Horn." Journal of Neurophysiology, vol. 80, no. 2, 1998, pp. 895-902.
Sequeira S, Näsström J. Low-affinity kainate receptors and long-lasting depression of NMDA-receptor-mediated currents in rat superficial dorsal horn. J Neurophysiol. 1998;80(2):895-902.
Sequeira, S., & Näsström, J. (1998). Low-affinity kainate receptors and long-lasting depression of NMDA-receptor-mediated currents in rat superficial dorsal horn. Journal of Neurophysiology, 80(2), 895-902.
Sequeira S, Näsström J. Low-affinity Kainate Receptors and Long-lasting Depression of NMDA-receptor-mediated Currents in Rat Superficial Dorsal Horn. J Neurophysiol. 1998;80(2):895-902. PubMed PMID: 9705476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-affinity kainate receptors and long-lasting depression of NMDA-receptor-mediated currents in rat superficial dorsal horn. AU - Sequeira,S, AU - Näsström,J, PY - 1998/8/15/pubmed PY - 1998/8/15/medline PY - 1998/8/15/entrez SP - 895 EP - 902 JF - Journal of neurophysiology JO - J Neurophysiol VL - 80 IS - 2 N2 - In an in vitro spinal cord slice preparation whole cell electrophysiological recordings of rat superficial dorsal horn neurons responding differentially to glutamate (Glu) and N-methyl-D-aspartate (NMDA) were investigated systematically for the role of kainate (KA) receptors in modulating their activity. In these neurons, coapplication of Glu and NMDA, as well as application of Glu immediately before NMDA, induced long- and short-lasting depressions of NMDA-induced currents as well as depression of NMDA-receptor-mediated excitatory postsynaptic currents. KA applied before NMDA mimicked Glu-induced attenuating effects. Furthermore, the low-affinity KA receptor antagonist 5-nitro-6,7,8,9- tetrahydrobenzo[G]indole-2,3-dione-3-oxime potentiated Glu-induced NMDA-receptor-mediated currents in neurons responding differentially to Glu and NMDA. These results provide evidence for a novel mechanism, which may relate to classical long-term depression, involving low-affinity KA receptors in long-lasting modulation of NMDA-receptor-mediated currents. This implies a physiological role of KA receptors in long-term modulation of sensory transmission in the superficial dorsal horn of rat spinal cord. SN - 0022-3077 UR - https://www.unboundmedicine.com/medline/citation/9705476/Low_affinity_kainate_receptors_and_long_lasting_depression_of_NMDA_receptor_mediated_currents_in_rat_superficial_dorsal_horn_ L2 - https://journals.physiology.org/doi/10.1152/jn.1998.80.2.895?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -