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The frequency of Lewy bodies in a consecutive autopsy series.
Clin Neuropathol. 1998 Jul-Aug; 17(4):204-9.CN

Abstract

In a consecutive autopsy series comprising 284 subjects > or = 50 years, 22 cases (7.7%) revealed Lewy bodies (LBs) of whom 21 had LBs in substantia nigra and/or locus ceruleus and 9 (3.2%) in the cerebral cortex. Only one case had cortical LBs without concomitant inclusions in the brain stem. The mean age of subjects with LBs was significantly higher than in those without (78.0 vs. 72.3 years). Cortical LBs had not been demonstrated in routine HE stains in any case and their identification necessitated the use of staining for ubiquitin. Although great care was taken not to interpret globose neurofibrillary tangles (NFTs) as LBs, anti-tau staining revealed that many of the suspected LBs were in fact NFTs. Thus, we recommend to apply both anti-ubiquitin and anti-tau staining for the demonstration of cortical LBs. In this material 21 of the 22 cases with LBs (95.5%) also revealed Alzheimer type of pathology as compared with 187 of 262 cases without LBs (71.4%). This difference may be explained by the higher age of subjects with LBs. Altogether 96 of the 284 cases (33.8%) had cerebrovascular lesions. None of the 9 cases with cortical LBs were clinically demented, and our results do not support the assertion that Lewy body-associated dementias should outnumber those of vascular origins.

Authors+Show Affiliations

Department of Pathology, Vest-Agder Central Hospital, Kristiansand, Norway.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9707335

Citation

Lindboe, C F., and H B. Hansen. "The Frequency of Lewy Bodies in a Consecutive Autopsy Series." Clinical Neuropathology, vol. 17, no. 4, 1998, pp. 204-9.
Lindboe CF, Hansen HB. The frequency of Lewy bodies in a consecutive autopsy series. Clin Neuropathol. 1998;17(4):204-9.
Lindboe, C. F., & Hansen, H. B. (1998). The frequency of Lewy bodies in a consecutive autopsy series. Clinical Neuropathology, 17(4), 204-9.
Lindboe CF, Hansen HB. The Frequency of Lewy Bodies in a Consecutive Autopsy Series. Clin Neuropathol. 1998 Jul-Aug;17(4):204-9. PubMed PMID: 9707335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The frequency of Lewy bodies in a consecutive autopsy series. AU - Lindboe,C F, AU - Hansen,H B, PY - 1998/8/26/pubmed PY - 1998/8/26/medline PY - 1998/8/26/entrez SP - 204 EP - 9 JF - Clinical neuropathology JO - Clin Neuropathol VL - 17 IS - 4 N2 - In a consecutive autopsy series comprising 284 subjects > or = 50 years, 22 cases (7.7%) revealed Lewy bodies (LBs) of whom 21 had LBs in substantia nigra and/or locus ceruleus and 9 (3.2%) in the cerebral cortex. Only one case had cortical LBs without concomitant inclusions in the brain stem. The mean age of subjects with LBs was significantly higher than in those without (78.0 vs. 72.3 years). Cortical LBs had not been demonstrated in routine HE stains in any case and their identification necessitated the use of staining for ubiquitin. Although great care was taken not to interpret globose neurofibrillary tangles (NFTs) as LBs, anti-tau staining revealed that many of the suspected LBs were in fact NFTs. Thus, we recommend to apply both anti-ubiquitin and anti-tau staining for the demonstration of cortical LBs. In this material 21 of the 22 cases with LBs (95.5%) also revealed Alzheimer type of pathology as compared with 187 of 262 cases without LBs (71.4%). This difference may be explained by the higher age of subjects with LBs. Altogether 96 of the 284 cases (33.8%) had cerebrovascular lesions. None of the 9 cases with cortical LBs were clinically demented, and our results do not support the assertion that Lewy body-associated dementias should outnumber those of vascular origins. SN - 0722-5091 UR - https://www.unboundmedicine.com/medline/citation/9707335/The_frequency_of_Lewy_bodies_in_a_consecutive_autopsy_series_ DB - PRIME DP - Unbound Medicine ER -