Tags

Type your tag names separated by a space and hit enter

Ambulatory 24-hour blood pressure recordings in patients with Parkinson's disease with or without fludrocortisone.
Int J Clin Pharmacol Ther. 1998 Jul; 36(7):367-9.IJ

Abstract

Orthostatic hypotension is often associated with patients suffering from Parkinson's disease. Only few studies have been published about the ambulatory blood pressure in patients with Parkinson's disease. Fludrocortisone has been used in management of orthostatic hypotension. This study was made to determine the Circadian rhythm of blood pressure in healthy elderly people, in Parkinson's disease patients without orthostatic hypotension and Parkinson's disease patients with fludrocortisone medication for orthostatic hypotension. Ambulatory 24-hour blood pressure recordings were made in 20 elderly Parkinson's disease patients and 21 healthy elderly persons. Eight of the Parkinson's disease patients were on fludrocortisone (Florinef) therapy because of orthostatic hypotension. The mean daytime systolic blood pressure of Parkinson's disease patients without fludrocortisone was 123 mmHg and the mean nighttime systolic blood pressure was 121 mmHg. There was no significant difference between daytime and nighttime systolic blood pressure (Figure 1). Diastolic blood pressure in this group was significantly higher during the day (68 mmHg) than at night (63 mmHg) (Figure 2). The daytime blood pressure of control patients was 135/74 mmHg and at night 127/69 mmHg (Figures 1, 2). The blood pressure of Parkinson's disease patients with fludrocortisone was higher at night (156/83 mmHg) than during the day (134/77 mmHg) (Figures 1, 2). The daytime and nighttime systolic and diastolic blood pressure was significantly lower by non-fludrocortisone Parkinson patients than the blood pressure of fludrocortisone Parkinson patients (Figures 1, 2).

CONCLUSION

The Parkinson's disease patients were non-dippers and with fludrocortisone the blood pressure was higher at night than on day. On day, the blood pressure of the Parkinson's disease patients with fludrocortisone elevated to the level of controls.

Authors+Show Affiliations

Hakamäki T
Department of Medicine, Turku City Hospital, Turku, Finland.
Rajala T
No affiliation info available
Lehtonen A
No affiliation info available

MeSH

AgedAged, 80 and overAnti-Inflammatory AgentsAntiparkinson AgentsBlood PressureBlood Pressure Monitoring, AmbulatoryCircadian RhythmFludrocortisoneHumansHypotension, OrthostaticParkinson DiseaseReference Values

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

9707350

Citation

Hakamäki, T, et al. "Ambulatory 24-hour Blood Pressure Recordings in Patients With Parkinson's Disease With or Without Fludrocortisone." International Journal of Clinical Pharmacology and Therapeutics, vol. 36, no. 7, 1998, pp. 367-9.
Hakamäki T, Rajala T, Lehtonen A. Ambulatory 24-hour blood pressure recordings in patients with Parkinson's disease with or without fludrocortisone. Int J Clin Pharmacol Ther. 1998;36(7):367-9.
Hakamäki, T., Rajala, T., & Lehtonen, A. (1998). Ambulatory 24-hour blood pressure recordings in patients with Parkinson's disease with or without fludrocortisone. International Journal of Clinical Pharmacology and Therapeutics, 36(7), 367-9.
Hakamäki T, Rajala T, Lehtonen A. Ambulatory 24-hour Blood Pressure Recordings in Patients With Parkinson's Disease With or Without Fludrocortisone. Int J Clin Pharmacol Ther. 1998;36(7):367-9. PubMed PMID: 9707350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ambulatory 24-hour blood pressure recordings in patients with Parkinson's disease with or without fludrocortisone. AU - Hakamäki,T, AU - Rajala,T, AU - Lehtonen,A, PY - 1998/8/26/pubmed PY - 1998/8/26/medline PY - 1998/8/26/entrez SP - 367 EP - 9 JF - International journal of clinical pharmacology and therapeutics JO - Int J Clin Pharmacol Ther VL - 36 IS - 7 N2 - UNLABELLED: Orthostatic hypotension is often associated with patients suffering from Parkinson's disease. Only few studies have been published about the ambulatory blood pressure in patients with Parkinson's disease. Fludrocortisone has been used in management of orthostatic hypotension. This study was made to determine the Circadian rhythm of blood pressure in healthy elderly people, in Parkinson's disease patients without orthostatic hypotension and Parkinson's disease patients with fludrocortisone medication for orthostatic hypotension. Ambulatory 24-hour blood pressure recordings were made in 20 elderly Parkinson's disease patients and 21 healthy elderly persons. Eight of the Parkinson's disease patients were on fludrocortisone (Florinef) therapy because of orthostatic hypotension. The mean daytime systolic blood pressure of Parkinson's disease patients without fludrocortisone was 123 mmHg and the mean nighttime systolic blood pressure was 121 mmHg. There was no significant difference between daytime and nighttime systolic blood pressure (Figure 1). Diastolic blood pressure in this group was significantly higher during the day (68 mmHg) than at night (63 mmHg) (Figure 2). The daytime blood pressure of control patients was 135/74 mmHg and at night 127/69 mmHg (Figures 1, 2). The blood pressure of Parkinson's disease patients with fludrocortisone was higher at night (156/83 mmHg) than during the day (134/77 mmHg) (Figures 1, 2). The daytime and nighttime systolic and diastolic blood pressure was significantly lower by non-fludrocortisone Parkinson patients than the blood pressure of fludrocortisone Parkinson patients (Figures 1, 2). CONCLUSION: The Parkinson's disease patients were non-dippers and with fludrocortisone the blood pressure was higher at night than on day. On day, the blood pressure of the Parkinson's disease patients with fludrocortisone elevated to the level of controls. SN - 0946-1965 UR - https://www.unboundmedicine.com/medline/citation/9707350/Ambulatory_24_hour_blood_pressure_recordings_in_patients_with_Parkinson's_disease_with_or_without_fludrocortisone_ DB - PRIME DP - Unbound Medicine ER -