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The effect of furosemide on renal blood flow and renal tissue oxygen tension in dogs.
Ann Chir Gynaecol. 1976; 65(4):272-6.AC

Abstract

The effect of furosemide (2 mg/kg i.v.) on blood flowin the renal artery and the tissue oxygen tension of the renal cortex and medulla was investigated in six dogs. The flow was measured with an electromagnetic flowmeter and the tissue oxygen tension with IBC tissue oxygen electrodes. The flow in the renal artery increased significantly (p less than 0.05) 5-15 minutes after furosemide administration. 40 minutes after the injection the flow had returned to its initial level. The tissue oxygen tension of both the cortex and the medulla showed significant elevation following furosemide administration. The maximum increase of tissue oxygen tension was recorded 10-20 minutes after the injection. The oxygen tension values exceeded the initial level by 22% in the cortex and by 48% (p less than 0.001) in the medulla. Simultaneously, with the changes in oxygen tension, urine output increase considerably and urine osmolality declined. Application of these renal effects of furosemide in clinical work, particularly in cardiopulmonary bypass surgery, is discussed.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

970904

Citation

Nuutinen, L S., and S Tuononen. "The Effect of Furosemide On Renal Blood Flow and Renal Tissue Oxygen Tension in Dogs." Annales Chirurgiae Et Gynaecologiae, vol. 65, no. 4, 1976, pp. 272-6.
Nuutinen LS, Tuononen S. The effect of furosemide on renal blood flow and renal tissue oxygen tension in dogs. Ann Chir Gynaecol. 1976;65(4):272-6.
Nuutinen, L. S., & Tuononen, S. (1976). The effect of furosemide on renal blood flow and renal tissue oxygen tension in dogs. Annales Chirurgiae Et Gynaecologiae, 65(4), 272-6.
Nuutinen LS, Tuononen S. The Effect of Furosemide On Renal Blood Flow and Renal Tissue Oxygen Tension in Dogs. Ann Chir Gynaecol. 1976;65(4):272-6. PubMed PMID: 970904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of furosemide on renal blood flow and renal tissue oxygen tension in dogs. AU - Nuutinen,L S, AU - Tuononen,S, PY - 1976/1/1/pubmed PY - 1976/1/1/medline PY - 1976/1/1/entrez SP - 272 EP - 6 JF - Annales chirurgiae et gynaecologiae JO - Ann Chir Gynaecol VL - 65 IS - 4 N2 - The effect of furosemide (2 mg/kg i.v.) on blood flowin the renal artery and the tissue oxygen tension of the renal cortex and medulla was investigated in six dogs. The flow was measured with an electromagnetic flowmeter and the tissue oxygen tension with IBC tissue oxygen electrodes. The flow in the renal artery increased significantly (p less than 0.05) 5-15 minutes after furosemide administration. 40 minutes after the injection the flow had returned to its initial level. The tissue oxygen tension of both the cortex and the medulla showed significant elevation following furosemide administration. The maximum increase of tissue oxygen tension was recorded 10-20 minutes after the injection. The oxygen tension values exceeded the initial level by 22% in the cortex and by 48% (p less than 0.001) in the medulla. Simultaneously, with the changes in oxygen tension, urine output increase considerably and urine osmolality declined. Application of these renal effects of furosemide in clinical work, particularly in cardiopulmonary bypass surgery, is discussed. SN - 0355-9521 UR - https://www.unboundmedicine.com/medline/citation/970904/The_effect_of_furosemide_on_renal_blood_flow_and_renal_tissue_oxygen_tension_in_dogs_ DB - PRIME DP - Unbound Medicine ER -