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CC chemokine receptor 5 polymorphism in rheumatoid arthritis.
J Rheumatol. 1998 Aug; 25(8):1462-5.JR

Abstract

OBJECTIVE

Some chemokine receptors have been shown to be co-receptors for human immunodeficiency virus (HIV-1). A 32 base pair deletion allele in the CC chemokine receptor 5 gene (CCR5 delta32 allele) affects both transmission of HIV-1 and acquired immunodeficiency syndrome (AIDS)-free survival. Chemokines are suggested to be critical for establishment of inflammatory processes in autoimmune diseases such as rheumatoid arthritis (RA). We hypothesized that the defective allele may modulate the inflammatory process in RA.

METHODS

Using polymerase chain reaction methods, we investigated the significance of the CCR5 delta32 allele in 163 Danish patients with RA and monitored clinical and paraclinical variables.

RESULTS

The gene frequency of the CCR5 delta32 allele (0.10) did not deviate significantly from healthy controls and from that reported in healthy Caucasian populations, nor did the distribution deviate from the Hardy-Weinberg predictions (131 wild type, 30 heterozygous, 2 homozygous for the deletion allele; p = 0.85). However, a significantly increased proportion of those carrying the deletion allele were negative for IgM rheumatoid factor (RF) compared to those homozygous for the normal allele (29 vs 9%; p = 0.007). The proportion of CCR5 delta32 allele carriers with swollen joints was decreased compared to those homozygous for the normal allele (35 vs 58%, respectively; p = 0.03), as was the duration of morning stiffness (median 0 vs 60 min, respectively; p = 0.0002).

CONCLUSION

The CCR5 delta32 allele seems to have some influence on RA variables including RF, which suggests that inhibition of chemokine receptors might be a potential target for disease modifying therapy in RA.

Authors+Show Affiliations

Department of Clinical Immunology, The National University Hospital (Rigshospitalet), Copenhagen, Denmark. Garred@post5.tele.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9712084

Citation

Garred, P, et al. "CC Chemokine Receptor 5 Polymorphism in Rheumatoid Arthritis." The Journal of Rheumatology, vol. 25, no. 8, 1998, pp. 1462-5.
Garred P, Madsen HO, Petersen J, et al. CC chemokine receptor 5 polymorphism in rheumatoid arthritis. J Rheumatol. 1998;25(8):1462-5.
Garred, P., Madsen, H. O., Petersen, J., Marquart, H., Hansen, T. M., Freiesleben Sørensen, S., Volck, B., Svejgaard, A., & Andersen, V. (1998). CC chemokine receptor 5 polymorphism in rheumatoid arthritis. The Journal of Rheumatology, 25(8), 1462-5.
Garred P, et al. CC Chemokine Receptor 5 Polymorphism in Rheumatoid Arthritis. J Rheumatol. 1998;25(8):1462-5. PubMed PMID: 9712084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CC chemokine receptor 5 polymorphism in rheumatoid arthritis. AU - Garred,P, AU - Madsen,H O, AU - Petersen,J, AU - Marquart,H, AU - Hansen,T M, AU - Freiesleben Sørensen,S, AU - Volck,B, AU - Svejgaard,A, AU - Andersen,V, PY - 1998/8/26/pubmed PY - 1998/8/26/medline PY - 1998/8/26/entrez SP - 1462 EP - 5 JF - The Journal of rheumatology JO - J. Rheumatol. VL - 25 IS - 8 N2 - OBJECTIVE: Some chemokine receptors have been shown to be co-receptors for human immunodeficiency virus (HIV-1). A 32 base pair deletion allele in the CC chemokine receptor 5 gene (CCR5 delta32 allele) affects both transmission of HIV-1 and acquired immunodeficiency syndrome (AIDS)-free survival. Chemokines are suggested to be critical for establishment of inflammatory processes in autoimmune diseases such as rheumatoid arthritis (RA). We hypothesized that the defective allele may modulate the inflammatory process in RA. METHODS: Using polymerase chain reaction methods, we investigated the significance of the CCR5 delta32 allele in 163 Danish patients with RA and monitored clinical and paraclinical variables. RESULTS: The gene frequency of the CCR5 delta32 allele (0.10) did not deviate significantly from healthy controls and from that reported in healthy Caucasian populations, nor did the distribution deviate from the Hardy-Weinberg predictions (131 wild type, 30 heterozygous, 2 homozygous for the deletion allele; p = 0.85). However, a significantly increased proportion of those carrying the deletion allele were negative for IgM rheumatoid factor (RF) compared to those homozygous for the normal allele (29 vs 9%; p = 0.007). The proportion of CCR5 delta32 allele carriers with swollen joints was decreased compared to those homozygous for the normal allele (35 vs 58%, respectively; p = 0.03), as was the duration of morning stiffness (median 0 vs 60 min, respectively; p = 0.0002). CONCLUSION: The CCR5 delta32 allele seems to have some influence on RA variables including RF, which suggests that inhibition of chemokine receptors might be a potential target for disease modifying therapy in RA. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/9712084/CC_chemokine_receptor_5_polymorphism_in_rheumatoid_arthritis_ L2 - http://www.diseaseinfosearch.org/result/592 DB - PRIME DP - Unbound Medicine ER -