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Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics.

Abstract

BACKGROUND

Impulsive violence, suicide, and depression are strongly associated with low concentrations of cerebrospinal fluid 5-hydroxyindoleacetic acid (CSF 5-HIAA). Increased suicide and trauma reported in some cholesterol-lowering trials may be related to altered concentrations of polyunsaturated fatty acids rather than cholesterol, a possible surrogate marker.

METHODS

CSF 5-HIAA and homovanillic acid (HVA), total cholesterol, and plasma fatty acid concentrations were examined in 176 subjects, including 49 healthy volunteers, and 88 early- and 39 late-onset alcoholics.

RESULTS

Among each group, polyunsaturated fatty acids predicted both CSF 5-HIAA and CSF HVA concentrations, but total cholesterol was unrelated to either neurotransmitter metabolite. The relationships between plasma 22: 6n3 and CSF 5-HIAA were significantly different when healthy volunteers (r = .35) were compared to early-onset alcoholics (r = -.38) (p < .0002).

CONCLUSIONS

Dietary studies are indicated to determine if essential fatty acid supplementation can influence central nervous system serotonin and dopamine metabolism and modify impulsive behaviors related to these neurotransmitters.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.

    , , , ,

    Source

    Biological psychiatry 44:4 1998 Aug 15 pg 235-42

    MeSH

    Adult
    Age of Onset
    Alcoholism
    Biomarkers
    Case-Control Studies
    Cholesterol
    Cross-Sectional Studies
    Docosahexaenoic Acids
    Dopamine
    Fatty Acids, Unsaturated
    Female
    Homovanillic Acid
    Humans
    Hydroxyindoleacetic Acid
    Male
    Middle Aged
    Regression Analysis
    Serotonin
    Statistics, Nonparametric

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    9715354

    Citation

    Hibbeln, J R., et al. "Essential Fatty Acids Predict Metabolites of Serotonin and Dopamine in Cerebrospinal Fluid Among Healthy Control Subjects, and Early- and Late-onset Alcoholics." Biological Psychiatry, vol. 44, no. 4, 1998, pp. 235-42.
    Hibbeln JR, Linnoila M, Umhau JC, et al. Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics. Biol Psychiatry. 1998;44(4):235-42.
    Hibbeln, J. R., Linnoila, M., Umhau, J. C., Rawlings, R., George, D. T., & Salem, N. (1998). Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics. Biological Psychiatry, 44(4), pp. 235-42.
    Hibbeln JR, et al. Essential Fatty Acids Predict Metabolites of Serotonin and Dopamine in Cerebrospinal Fluid Among Healthy Control Subjects, and Early- and Late-onset Alcoholics. Biol Psychiatry. 1998 Aug 15;44(4):235-42. PubMed PMID: 9715354.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics. AU - Hibbeln,J R, AU - Linnoila,M, AU - Umhau,J C, AU - Rawlings,R, AU - George,D T, AU - Salem,N,Jr PY - 1998/8/26/pubmed PY - 2001/3/28/medline PY - 1998/8/26/entrez SP - 235 EP - 42 JF - Biological psychiatry JO - Biol. Psychiatry VL - 44 IS - 4 N2 - BACKGROUND: Impulsive violence, suicide, and depression are strongly associated with low concentrations of cerebrospinal fluid 5-hydroxyindoleacetic acid (CSF 5-HIAA). Increased suicide and trauma reported in some cholesterol-lowering trials may be related to altered concentrations of polyunsaturated fatty acids rather than cholesterol, a possible surrogate marker. METHODS: CSF 5-HIAA and homovanillic acid (HVA), total cholesterol, and plasma fatty acid concentrations were examined in 176 subjects, including 49 healthy volunteers, and 88 early- and 39 late-onset alcoholics. RESULTS: Among each group, polyunsaturated fatty acids predicted both CSF 5-HIAA and CSF HVA concentrations, but total cholesterol was unrelated to either neurotransmitter metabolite. The relationships between plasma 22: 6n3 and CSF 5-HIAA were significantly different when healthy volunteers (r = .35) were compared to early-onset alcoholics (r = -.38) (p < .0002). CONCLUSIONS: Dietary studies are indicated to determine if essential fatty acid supplementation can influence central nervous system serotonin and dopamine metabolism and modify impulsive behaviors related to these neurotransmitters. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/9715354/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(98)00141-3 DB - PRIME DP - Unbound Medicine ER -