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Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics.
Biol Psychiatry 1998; 44(4):235-42BP

Abstract

BACKGROUND

Impulsive violence, suicide, and depression are strongly associated with low concentrations of cerebrospinal fluid 5-hydroxyindoleacetic acid (CSF 5-HIAA). Increased suicide and trauma reported in some cholesterol-lowering trials may be related to altered concentrations of polyunsaturated fatty acids rather than cholesterol, a possible surrogate marker.

METHODS

CSF 5-HIAA and homovanillic acid (HVA), total cholesterol, and plasma fatty acid concentrations were examined in 176 subjects, including 49 healthy volunteers, and 88 early- and 39 late-onset alcoholics.

RESULTS

Among each group, polyunsaturated fatty acids predicted both CSF 5-HIAA and CSF HVA concentrations, but total cholesterol was unrelated to either neurotransmitter metabolite. The relationships between plasma 22: 6n3 and CSF 5-HIAA were significantly different when healthy volunteers (r = .35) were compared to early-onset alcoholics (r = -.38) (p < .0002).

CONCLUSIONS

Dietary studies are indicated to determine if essential fatty acid supplementation can influence central nervous system serotonin and dopamine metabolism and modify impulsive behaviors related to these neurotransmitters.

Authors+Show Affiliations

Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9715354

Citation

Hibbeln, J R., et al. "Essential Fatty Acids Predict Metabolites of Serotonin and Dopamine in Cerebrospinal Fluid Among Healthy Control Subjects, and Early- and Late-onset Alcoholics." Biological Psychiatry, vol. 44, no. 4, 1998, pp. 235-42.
Hibbeln JR, Linnoila M, Umhau JC, et al. Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics. Biol Psychiatry. 1998;44(4):235-42.
Hibbeln, J. R., Linnoila, M., Umhau, J. C., Rawlings, R., George, D. T., & Salem, N. (1998). Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics. Biological Psychiatry, 44(4), pp. 235-42.
Hibbeln JR, et al. Essential Fatty Acids Predict Metabolites of Serotonin and Dopamine in Cerebrospinal Fluid Among Healthy Control Subjects, and Early- and Late-onset Alcoholics. Biol Psychiatry. 1998 Aug 15;44(4):235-42. PubMed PMID: 9715354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics. AU - Hibbeln,J R, AU - Linnoila,M, AU - Umhau,J C, AU - Rawlings,R, AU - George,D T, AU - Salem,N,Jr PY - 1998/8/26/pubmed PY - 2001/3/28/medline PY - 1998/8/26/entrez SP - 235 EP - 42 JF - Biological psychiatry JO - Biol. Psychiatry VL - 44 IS - 4 N2 - BACKGROUND: Impulsive violence, suicide, and depression are strongly associated with low concentrations of cerebrospinal fluid 5-hydroxyindoleacetic acid (CSF 5-HIAA). Increased suicide and trauma reported in some cholesterol-lowering trials may be related to altered concentrations of polyunsaturated fatty acids rather than cholesterol, a possible surrogate marker. METHODS: CSF 5-HIAA and homovanillic acid (HVA), total cholesterol, and plasma fatty acid concentrations were examined in 176 subjects, including 49 healthy volunteers, and 88 early- and 39 late-onset alcoholics. RESULTS: Among each group, polyunsaturated fatty acids predicted both CSF 5-HIAA and CSF HVA concentrations, but total cholesterol was unrelated to either neurotransmitter metabolite. The relationships between plasma 22: 6n3 and CSF 5-HIAA were significantly different when healthy volunteers (r = .35) were compared to early-onset alcoholics (r = -.38) (p < .0002). CONCLUSIONS: Dietary studies are indicated to determine if essential fatty acid supplementation can influence central nervous system serotonin and dopamine metabolism and modify impulsive behaviors related to these neurotransmitters. SN - 0006-3223 UR - http://www.unboundmedicine.com/medline/citation/9715354/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(98)00141-3 DB - PRIME DP - Unbound Medicine ER -