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Blood glucose control on Sunday in IDDM patients: intensified conventional insulin therapy versus continuous subcutaneous insulin infusion.
Diabetes Res Clin Pract. 1998 Jun; 40(3):175-80.DR

Abstract

We have assessed the capacity of continuous subcutaneous insulin infusion (CSII) to maintain good blood glucose metabolic control on Sundays, when waking is delayed, with reference to intensified conventional insulin therapy by multiple daily injections (MDI). The study lasted 3 weeks, including 3 week-ends. A total of 20 IDDM patients were selected for metabolic control: ten were treated by CSII and ten by MDI. Blood glucose was determined at least three times a day (fasting on waking, pre-lunch and pre-dinner). The times of blood glucose determinations and their values were recorded in a memory reflectance meter. Waking, the first blood glucose measurement and the first insulin injection (MDI) or bolus (CSII) were about 1 h later on Sundays than on a weekday (44 +/- 4 min in MDI group, P < 0.04; and 59 +/- 7 min in CSII group, P < 0.02). The times of the pre-lunch and pre-dinner blood glucose determinations were not significantly different. The mean waking and pre-lunch blood glucose values of the MDI group were higher on Sundays (11.5 +/- 3.8 and 9.7 +/- 4.5 mmol/l) than on weekdays (8.7 +/- 2.3 and 7.1 +/- 2.5 mmol/1)(P < 0.01). The pre-prandial blood glucose levels of the CSII group on Sundays and weekdays were not statistically different at any time. Changes in the waking time and the subsequent delay in the first insulin bolus on Sunday may alter blood glucose control in patients on MDI, but CSII allows such changes without any glycemic side effects.

Authors+Show Affiliations

Guerci B
Service de Diabétologie, Maladies Métaboliques et Nutrition, Centre d'Investigation Clinique-INSERM/CHU de Nancy, Hôpital Jeanne d'Arc, Centre Hospitalo-Universitaire de Nancy, Toul, France.
Meyer L
No affiliation info available
Delbachian I
No affiliation info available
Kolopp M
No affiliation info available
Ziegler O
No affiliation info available
Drouin P
No affiliation info available

MeSH

AdultBlood GlucoseDiabetes Mellitus, Type 1HumansInfusion Pumps, ImplantableInsulinInsulin Infusion SystemsMiddle AgedTime Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9716921

Citation

Guerci, B, et al. "Blood Glucose Control On Sunday in IDDM Patients: Intensified Conventional Insulin Therapy Versus Continuous Subcutaneous Insulin Infusion." Diabetes Research and Clinical Practice, vol. 40, no. 3, 1998, pp. 175-80.
Guerci B, Meyer L, Delbachian I, et al. Blood glucose control on Sunday in IDDM patients: intensified conventional insulin therapy versus continuous subcutaneous insulin infusion. Diabetes Res Clin Pract. 1998;40(3):175-80.
Guerci, B., Meyer, L., Delbachian, I., Kolopp, M., Ziegler, O., & Drouin, P. (1998). Blood glucose control on Sunday in IDDM patients: intensified conventional insulin therapy versus continuous subcutaneous insulin infusion. Diabetes Research and Clinical Practice, 40(3), 175-80.
Guerci B, et al. Blood Glucose Control On Sunday in IDDM Patients: Intensified Conventional Insulin Therapy Versus Continuous Subcutaneous Insulin Infusion. Diabetes Res Clin Pract. 1998;40(3):175-80. PubMed PMID: 9716921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blood glucose control on Sunday in IDDM patients: intensified conventional insulin therapy versus continuous subcutaneous insulin infusion. AU - Guerci,B, AU - Meyer,L, AU - Delbachian,I, AU - Kolopp,M, AU - Ziegler,O, AU - Drouin,P, PY - 1998/8/26/pubmed PY - 1998/8/26/medline PY - 1998/8/26/entrez SP - 175 EP - 80 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 40 IS - 3 N2 - We have assessed the capacity of continuous subcutaneous insulin infusion (CSII) to maintain good blood glucose metabolic control on Sundays, when waking is delayed, with reference to intensified conventional insulin therapy by multiple daily injections (MDI). The study lasted 3 weeks, including 3 week-ends. A total of 20 IDDM patients were selected for metabolic control: ten were treated by CSII and ten by MDI. Blood glucose was determined at least three times a day (fasting on waking, pre-lunch and pre-dinner). The times of blood glucose determinations and their values were recorded in a memory reflectance meter. Waking, the first blood glucose measurement and the first insulin injection (MDI) or bolus (CSII) were about 1 h later on Sundays than on a weekday (44 +/- 4 min in MDI group, P < 0.04; and 59 +/- 7 min in CSII group, P < 0.02). The times of the pre-lunch and pre-dinner blood glucose determinations were not significantly different. The mean waking and pre-lunch blood glucose values of the MDI group were higher on Sundays (11.5 +/- 3.8 and 9.7 +/- 4.5 mmol/l) than on weekdays (8.7 +/- 2.3 and 7.1 +/- 2.5 mmol/1)(P < 0.01). The pre-prandial blood glucose levels of the CSII group on Sundays and weekdays were not statistically different at any time. Changes in the waking time and the subsequent delay in the first insulin bolus on Sunday may alter blood glucose control in patients on MDI, but CSII allows such changes without any glycemic side effects. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/9716921/Blood_glucose_control_on_Sunday_in_IDDM_patients:_intensified_conventional_insulin_therapy_versus_continuous_subcutaneous_insulin_infusion_ DB - PRIME DP - Unbound Medicine ER -

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