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Dietary fat type and energy restriction interactively influence plasma leptin concentration in rats.
J Lipid Res. 1998 Aug; 39(8):1655-60.JL

Abstract

To investigate whether dietary fat source and energy restriction interactively influence plasma leptin levels and its association of leptin with insulin action, rats were fed diets containing either fish, safflower oil, or beef tallow (20% wt/wt) for 10 weeks. Groups of rats consumed each diet ad libitum or at 85% or 70% of ad libitum energy intake in a design that held fat intake constant. Graded levels of energy restriction caused body weight to decrease (P < 0.001) differently according to the dietary fat provided. Plasma leptin concentrations were 60% higher (P < 0.05) in the groups fed fish oil and safflower oil ad libitum compared with those in the beef tallow group, despite smaller perirenal fat mass and fat cell size in the fish oil-fed animals. Energy restriction resulted in a 62% decrease (P < 0.05) in leptin levels in fish oil- and safflower oil-fed rats, whereas no changes were observed in beef tallow-fed animals. Plasma insulin levels were lower (P < 0.05) in the fish oil group fed ad libitum compared with those in the two other diet groups. These data demonstrate a hyperleptinemic effect in animals consuming diets rich in polyunsaturated fatty acid, which can be normalized to the level of saturated fat consumption by mild energy restriction. Thus, dietary fatty acid composition, independent of adipose tissue mass, is an important determinant of circulating leptin level in diet-induced obesity.

Authors+Show Affiliations

School of Dietetics and Human Nutrition, Macdonald Campus of McGill University, Ste Anne de Bellevue P.Q., Canada.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9717726

Citation

Cha, M C., and P J. Jones. "Dietary Fat Type and Energy Restriction Interactively Influence Plasma Leptin Concentration in Rats." Journal of Lipid Research, vol. 39, no. 8, 1998, pp. 1655-60.
Cha MC, Jones PJ. Dietary fat type and energy restriction interactively influence plasma leptin concentration in rats. J Lipid Res. 1998;39(8):1655-60.
Cha, M. C., & Jones, P. J. (1998). Dietary fat type and energy restriction interactively influence plasma leptin concentration in rats. Journal of Lipid Research, 39(8), 1655-60.
Cha MC, Jones PJ. Dietary Fat Type and Energy Restriction Interactively Influence Plasma Leptin Concentration in Rats. J Lipid Res. 1998;39(8):1655-60. PubMed PMID: 9717726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat type and energy restriction interactively influence plasma leptin concentration in rats. AU - Cha,M C, AU - Jones,P J, PY - 1998/8/26/pubmed PY - 1998/8/26/medline PY - 1998/8/26/entrez SP - 1655 EP - 60 JF - Journal of lipid research JO - J. Lipid Res. VL - 39 IS - 8 N2 - To investigate whether dietary fat source and energy restriction interactively influence plasma leptin levels and its association of leptin with insulin action, rats were fed diets containing either fish, safflower oil, or beef tallow (20% wt/wt) for 10 weeks. Groups of rats consumed each diet ad libitum or at 85% or 70% of ad libitum energy intake in a design that held fat intake constant. Graded levels of energy restriction caused body weight to decrease (P < 0.001) differently according to the dietary fat provided. Plasma leptin concentrations were 60% higher (P < 0.05) in the groups fed fish oil and safflower oil ad libitum compared with those in the beef tallow group, despite smaller perirenal fat mass and fat cell size in the fish oil-fed animals. Energy restriction resulted in a 62% decrease (P < 0.05) in leptin levels in fish oil- and safflower oil-fed rats, whereas no changes were observed in beef tallow-fed animals. Plasma insulin levels were lower (P < 0.05) in the fish oil group fed ad libitum compared with those in the two other diet groups. These data demonstrate a hyperleptinemic effect in animals consuming diets rich in polyunsaturated fatty acid, which can be normalized to the level of saturated fat consumption by mild energy restriction. Thus, dietary fatty acid composition, independent of adipose tissue mass, is an important determinant of circulating leptin level in diet-induced obesity. SN - 0022-2275 UR - https://www.unboundmedicine.com/medline/citation/9717726/Dietary_fat_type_and_energy_restriction_interactively_influence_plasma_leptin_concentration_in_rats_ L2 - http://www.jlr.org/cgi/pmidlookup?view=long&amp;pmid=9717726 DB - PRIME DP - Unbound Medicine ER -