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Comparison of (-)-stepholidine and D1 or D2 agonists on unit firing of globus pallidus in 6-hydroxydopamine-lesioned rats.
Life Sci. 1998; 63(7):537-44.LS

Abstract

(-)-Stepholidine(SPD), isolated from the Chinese herb Stephania, is demonstrated to be a DA antagonist, but it also shows D1 agonistic action on rotational behavior in unilateral 6-hydroxydopamine (6-OHDA) lesioned rats. The present study further ascertains its D1 agonistic property on firing activity of globus pallidus (GP) in control and 6-OHDA-lesioned rats. In the control rats, the firing activities of the GP neurons elicited by DA agonists (i.v.), such as apomorphine (D1/D2), SKF38393 (D1), and LY171555 (D2), were readily reversed by SPD (4 mg/kg, i.v.); but SPD, per se, induced variable alterations. In the 6-OHDA-lesioned rats, apomorphine, SKF38393 and LY171555 displayed the marked inhibition as well as excitation on the unit firing. The individual firing variations (87.1+/-17.8, 55.1+/-15.7 and 62.1+/-16.7%, respectively) were much larger than those in the control group, and were completely abolished by SPD (2 mg/kg). However, SPD also showed D1 partial agonistic action on the GP neuron firing. Moreover, the pre-blockade of D2 receptors with spiperone (0.5 mg/kg, i.v.), SPD exhibited the D1 agonist action which was reversed by the D1 antagonist SCH23390. These results suggest that SPD has a dual action on the GP neuron firing in the 6-OHDA-lesioned rats, i.e., antagonist to D2 DA receptors and partial agonist to D1 receptors.

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Authors+Show Affiliations

Zhang XX
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, PR China.
Zhu ZT
No affiliation info available
Jin GZ
No affiliation info available

MeSH

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAnimalsBenzazepinesBerberineCalcium Channel BlockersDopamine AgonistsDopamine AntagonistsDrug InteractionsGlobus PallidusMaleNeuronsOxidopamineRatsRats, Sprague-DawleyReceptors, Dopamine D1Receptors, Dopamine D2

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9718079

Citation

Zhang, X X., et al. "Comparison of (-)-stepholidine and D1 or D2 Agonists On Unit Firing of Globus Pallidus in 6-hydroxydopamine-lesioned Rats." Life Sciences, vol. 63, no. 7, 1998, pp. 537-44.
Zhang XX, Zhu ZT, Jin GZ. Comparison of (-)-stepholidine and D1 or D2 agonists on unit firing of globus pallidus in 6-hydroxydopamine-lesioned rats. Life Sci. 1998;63(7):537-44.
Zhang, X. X., Zhu, Z. T., & Jin, G. Z. (1998). Comparison of (-)-stepholidine and D1 or D2 agonists on unit firing of globus pallidus in 6-hydroxydopamine-lesioned rats. Life Sciences, 63(7), 537-44.
Zhang XX, Zhu ZT, Jin GZ. Comparison of (-)-stepholidine and D1 or D2 Agonists On Unit Firing of Globus Pallidus in 6-hydroxydopamine-lesioned Rats. Life Sci. 1998;63(7):537-44. PubMed PMID: 9718079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of (-)-stepholidine and D1 or D2 agonists on unit firing of globus pallidus in 6-hydroxydopamine-lesioned rats. AU - Zhang,X X, AU - Zhu,Z T, AU - Jin,G Z, PY - 1998/8/26/pubmed PY - 1998/8/26/medline PY - 1998/8/26/entrez SP - 537 EP - 44 JF - Life sciences JO - Life Sci VL - 63 IS - 7 N2 - (-)-Stepholidine(SPD), isolated from the Chinese herb Stephania, is demonstrated to be a DA antagonist, but it also shows D1 agonistic action on rotational behavior in unilateral 6-hydroxydopamine (6-OHDA) lesioned rats. The present study further ascertains its D1 agonistic property on firing activity of globus pallidus (GP) in control and 6-OHDA-lesioned rats. In the control rats, the firing activities of the GP neurons elicited by DA agonists (i.v.), such as apomorphine (D1/D2), SKF38393 (D1), and LY171555 (D2), were readily reversed by SPD (4 mg/kg, i.v.); but SPD, per se, induced variable alterations. In the 6-OHDA-lesioned rats, apomorphine, SKF38393 and LY171555 displayed the marked inhibition as well as excitation on the unit firing. The individual firing variations (87.1+/-17.8, 55.1+/-15.7 and 62.1+/-16.7%, respectively) were much larger than those in the control group, and were completely abolished by SPD (2 mg/kg). However, SPD also showed D1 partial agonistic action on the GP neuron firing. Moreover, the pre-blockade of D2 receptors with spiperone (0.5 mg/kg, i.v.), SPD exhibited the D1 agonist action which was reversed by the D1 antagonist SCH23390. These results suggest that SPD has a dual action on the GP neuron firing in the 6-OHDA-lesioned rats, i.e., antagonist to D2 DA receptors and partial agonist to D1 receptors. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/9718079/Comparison_of_____stepholidine_and_D1_or_D2_agonists_on_unit_firing_of_globus_pallidus_in_6_hydroxydopamine_lesioned_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S002432059800304X DB - PRIME DP - Unbound Medicine ER -