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Vegetable and fruit consumption and prostate cancer risk: a cohort study in The Netherlands.

Abstract

The association between 21 vegetables and eight fruits and prostate cancer risk was assessed in the Netherlands Cohort Study among 58,279 men of ages 55-69 years at baseline in 1986. After 6.3 years of follow-up, 610 cases with complete vegetable data and 642 cases with complete fruit data were available for analysis. In multivariate case-cohort analyses, the following rate ratios (RRs) and 95% confidence intervals (CIs) for vegetable consumption were found (comparing highest versus lowest quintile): total vegetables (RR, 0.80; CI, 0.57-1.12); prepared vegetables (RR, 0.85; CI, 0.61-1.19); and raw vegetables (RR, 0.96; CI, 0.69-1.34). For vegetables categorized in botanical groups, no associations were found except for consumption of pulses (RR, 0.71; CI, 0.51-0.98; P for trend, 0.01). The RRs for total fruit and citrus fruit were 1.31 (CI, 0.96-1.79) and 1.27 (CI, 0.93-1.73), respectively; the corresponding Ps for trend were 0.02 and 0.01, respectively. In a continuous model, no association for total fruit was observed. Individual vegetables and fruits were evaluated as continuous variables (g/day). Nonsignificant inverse associations (RRs per increment of 25 g/day) were found for consumption of kale (RR, 0.74), raw endive (RR, 0.72), mandarins (RR, 0.75), and raisins or other dried fruit (RR, 0.49). Observed positive associations were significant for consumption of leek (RR, 1.38) and oranges (RR, 1.07) and nonsignificant for sweet peppers (RR, 1.60) and mushrooms (RR, 1.49). Results in subgroups of cases were more or less consistent with the overall results. From our study, we cannot conclude that vegetable consumption is important in prostate cancer etiology, but for certain vegetables or fruits, an association cannot be excluded.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Maastricht University, The Netherlands. AG.Schuurman@Epid.UniMass.NL

    , ,

    Source

    MeSH

    Age Distribution
    Aged
    Cohort Studies
    Confidence Intervals
    Dietary Fiber
    Fruit
    Humans
    Incidence
    Male
    Middle Aged
    Multivariate Analysis
    Netherlands
    Prostatic Neoplasms
    Risk Factors
    Surveys and Questionnaires
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    9718219

    Citation

    Schuurman, A G., et al. "Vegetable and Fruit Consumption and Prostate Cancer Risk: a Cohort Study in the Netherlands." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 7, no. 8, 1998, pp. 673-80.
    Schuurman AG, Goldbohm RA, Dorant E, et al. Vegetable and fruit consumption and prostate cancer risk: a cohort study in The Netherlands. Cancer Epidemiol Biomarkers Prev. 1998;7(8):673-80.
    Schuurman, A. G., Goldbohm, R. A., Dorant, E., & van den Brandt, P. A. (1998). Vegetable and fruit consumption and prostate cancer risk: a cohort study in The Netherlands. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 7(8), pp. 673-80.
    Schuurman AG, et al. Vegetable and Fruit Consumption and Prostate Cancer Risk: a Cohort Study in the Netherlands. Cancer Epidemiol Biomarkers Prev. 1998;7(8):673-80. PubMed PMID: 9718219.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vegetable and fruit consumption and prostate cancer risk: a cohort study in The Netherlands. AU - Schuurman,A G, AU - Goldbohm,R A, AU - Dorant,E, AU - van den Brandt,P A, PY - 1998/8/26/pubmed PY - 1998/8/26/medline PY - 1998/8/26/entrez SP - 673 EP - 80 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 7 IS - 8 N2 - The association between 21 vegetables and eight fruits and prostate cancer risk was assessed in the Netherlands Cohort Study among 58,279 men of ages 55-69 years at baseline in 1986. After 6.3 years of follow-up, 610 cases with complete vegetable data and 642 cases with complete fruit data were available for analysis. In multivariate case-cohort analyses, the following rate ratios (RRs) and 95% confidence intervals (CIs) for vegetable consumption were found (comparing highest versus lowest quintile): total vegetables (RR, 0.80; CI, 0.57-1.12); prepared vegetables (RR, 0.85; CI, 0.61-1.19); and raw vegetables (RR, 0.96; CI, 0.69-1.34). For vegetables categorized in botanical groups, no associations were found except for consumption of pulses (RR, 0.71; CI, 0.51-0.98; P for trend, 0.01). The RRs for total fruit and citrus fruit were 1.31 (CI, 0.96-1.79) and 1.27 (CI, 0.93-1.73), respectively; the corresponding Ps for trend were 0.02 and 0.01, respectively. In a continuous model, no association for total fruit was observed. Individual vegetables and fruits were evaluated as continuous variables (g/day). Nonsignificant inverse associations (RRs per increment of 25 g/day) were found for consumption of kale (RR, 0.74), raw endive (RR, 0.72), mandarins (RR, 0.75), and raisins or other dried fruit (RR, 0.49). Observed positive associations were significant for consumption of leek (RR, 1.38) and oranges (RR, 1.07) and nonsignificant for sweet peppers (RR, 1.60) and mushrooms (RR, 1.49). Results in subgroups of cases were more or less consistent with the overall results. From our study, we cannot conclude that vegetable consumption is important in prostate cancer etiology, but for certain vegetables or fruits, an association cannot be excluded. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/9718219/Vegetable_and_fruit_consumption_and_prostate_cancer_risk:_a_cohort_study_in_The_Netherlands_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=9718219 DB - PRIME DP - Unbound Medicine ER -