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Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer.
J Natl Cancer Inst 1998; 90(16):1219-24JNCI

Abstract

BACKGROUND

In a recent randomized intervention trial, the risk of prostate cancer for men receiving a daily supplement of 200 microg selenium was one third of that for men receiving placebo. By use of a nested case-control design within a prospective study, i.e., the Health Professionals Follow-Up Study, we investigated the association between risk of prostate cancer and prediagnostic level of selenium in toenails, a measure of long-term selenium intake.

METHODS

In 1986, 51,529 male health professionals aged 40-75 years responded to a mailed questionnaire to form the prospective study. In 1987, 33,737 cohort members provided toenail clippings. In 1988, 1990, 1992, and 1994, follow-up questionnaires were mailed. From 1989 through 1994, 181 new cases of advanced prostate cancer were reported. Case and control subjects were matched by age, smoking status, and month of toenail return. Selenium levels were determined by neutron activation. All P values are two-sided.

RESULTS

The selenium level in toenails varied substantially among men, with quintile medians ranging from 0.66 to 1.14 microg/g for control subjects. When matched case-control data were analyzed, higher selenium levels were associated with a reduced risk of advanced prostate cancer (odds ratio [OR] for comparison of highest to lowest quintile = 0.49; 95% confidence interval [CI] = 0.25-0.96; P for trend = .11). After additionally controlling for family history of prostate cancer, body mass index, calcium intake, lycopene intake, saturated fat intake, vasectomy, and geographical region, the OR was 0.35 (95% CI = 0.16-0.78; P for trend = .03).

CONCLUSIONS

Our results support earlier findings that higher selenium intakes may reduce the risk of prostate cancer. Further prospective studies and randomized trials of this relationship should be conducted.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9719083

Citation

Yoshizawa, K, et al. "Study of Prediagnostic Selenium Level in Toenails and the Risk of Advanced Prostate Cancer." Journal of the National Cancer Institute, vol. 90, no. 16, 1998, pp. 1219-24.
Yoshizawa K, Willett WC, Morris SJ, et al. Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer. J Natl Cancer Inst. 1998;90(16):1219-24.
Yoshizawa, K., Willett, W. C., Morris, S. J., Stampfer, M. J., Spiegelman, D., Rimm, E. B., & Giovannucci, E. (1998). Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer. Journal of the National Cancer Institute, 90(16), pp. 1219-24.
Yoshizawa K, et al. Study of Prediagnostic Selenium Level in Toenails and the Risk of Advanced Prostate Cancer. J Natl Cancer Inst. 1998 Aug 19;90(16):1219-24. PubMed PMID: 9719083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer. AU - Yoshizawa,K, AU - Willett,W C, AU - Morris,S J, AU - Stampfer,M J, AU - Spiegelman,D, AU - Rimm,E B, AU - Giovannucci,E, PY - 1998/8/27/pubmed PY - 1998/8/27/medline PY - 1998/8/27/entrez SP - 1219 EP - 24 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 90 IS - 16 N2 - BACKGROUND: In a recent randomized intervention trial, the risk of prostate cancer for men receiving a daily supplement of 200 microg selenium was one third of that for men receiving placebo. By use of a nested case-control design within a prospective study, i.e., the Health Professionals Follow-Up Study, we investigated the association between risk of prostate cancer and prediagnostic level of selenium in toenails, a measure of long-term selenium intake. METHODS: In 1986, 51,529 male health professionals aged 40-75 years responded to a mailed questionnaire to form the prospective study. In 1987, 33,737 cohort members provided toenail clippings. In 1988, 1990, 1992, and 1994, follow-up questionnaires were mailed. From 1989 through 1994, 181 new cases of advanced prostate cancer were reported. Case and control subjects were matched by age, smoking status, and month of toenail return. Selenium levels were determined by neutron activation. All P values are two-sided. RESULTS: The selenium level in toenails varied substantially among men, with quintile medians ranging from 0.66 to 1.14 microg/g for control subjects. When matched case-control data were analyzed, higher selenium levels were associated with a reduced risk of advanced prostate cancer (odds ratio [OR] for comparison of highest to lowest quintile = 0.49; 95% confidence interval [CI] = 0.25-0.96; P for trend = .11). After additionally controlling for family history of prostate cancer, body mass index, calcium intake, lycopene intake, saturated fat intake, vasectomy, and geographical region, the OR was 0.35 (95% CI = 0.16-0.78; P for trend = .03). CONCLUSIONS: Our results support earlier findings that higher selenium intakes may reduce the risk of prostate cancer. Further prospective studies and randomized trials of this relationship should be conducted. SN - 0027-8874 UR - https://www.unboundmedicine.com/medline/citation/9719083/Study_of_prediagnostic_selenium_level_in_toenails_and_the_risk_of_advanced_prostate_cancer_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/90.16.1219 DB - PRIME DP - Unbound Medicine ER -