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[Patients with acute respiratory distress syndrome mechanically ventilated in prone position].
Ugeskr Laeger. 1998 Aug 03; 160(32):4649-50.UL

Abstract

Animal experiments and human studies have shown better oxygenation in mechanically ventilated patients with ARDS when the patient is situated in the prone position. In contradiction to former theories of a gravitational gradient of lung perfusion, a number of investigators have found that lung perfusion is preferentially distributed to the dorsal lung regions regardless of body position. The basal atelectasis and oedema in ARDS are resolved and only partly distributed anteriorly in the prone position, and these areas are thereby better ventilated. The combination of better ventilation and unchanged perfusion improves the ventilation/perfusion ratio and decreases the shunt in the prone position. In two cases of prone position in mechanically ventilated patients the PaO2/FiO2 ratio increased from 7.5 to 14.3 and from 8.8 to 19.8 after one hour in the prone position, and some of the improvement was permanent. Prone position has only minor side effects and is recommended as the first choice amongst adjunct therapies in mechanical ventilation in patients with ARDS remaining hypoxic in conventional therapy in the supine position.

Authors+Show Affiliations

Aalborg Sygehus, anaestesiafdelingen.No affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

dan

PubMed ID

9719747

Citation

Nielsen, L S., and L Kirkegaard. "[Patients With Acute Respiratory Distress Syndrome Mechanically Ventilated in Prone Position]." Ugeskrift for Laeger, vol. 160, no. 32, 1998, pp. 4649-50.
Nielsen LS, Kirkegaard L. [Patients with acute respiratory distress syndrome mechanically ventilated in prone position]. Ugeskr Laeger. 1998;160(32):4649-50.
Nielsen, L. S., & Kirkegaard, L. (1998). [Patients with acute respiratory distress syndrome mechanically ventilated in prone position]. Ugeskrift for Laeger, 160(32), 4649-50.
Nielsen LS, Kirkegaard L. [Patients With Acute Respiratory Distress Syndrome Mechanically Ventilated in Prone Position]. Ugeskr Laeger. 1998 Aug 3;160(32):4649-50. PubMed PMID: 9719747.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Patients with acute respiratory distress syndrome mechanically ventilated in prone position]. AU - Nielsen,L S, AU - Kirkegaard,L, PY - 1998/8/28/pubmed PY - 1998/8/28/medline PY - 1998/8/28/entrez SP - 4649 EP - 50 JF - Ugeskrift for laeger JO - Ugeskr Laeger VL - 160 IS - 32 N2 - Animal experiments and human studies have shown better oxygenation in mechanically ventilated patients with ARDS when the patient is situated in the prone position. In contradiction to former theories of a gravitational gradient of lung perfusion, a number of investigators have found that lung perfusion is preferentially distributed to the dorsal lung regions regardless of body position. The basal atelectasis and oedema in ARDS are resolved and only partly distributed anteriorly in the prone position, and these areas are thereby better ventilated. The combination of better ventilation and unchanged perfusion improves the ventilation/perfusion ratio and decreases the shunt in the prone position. In two cases of prone position in mechanically ventilated patients the PaO2/FiO2 ratio increased from 7.5 to 14.3 and from 8.8 to 19.8 after one hour in the prone position, and some of the improvement was permanent. Prone position has only minor side effects and is recommended as the first choice amongst adjunct therapies in mechanical ventilation in patients with ARDS remaining hypoxic in conventional therapy in the supine position. SN - 0041-5782 UR - https://www.unboundmedicine.com/medline/citation/9719747/[Patients_with_acute_respiratory_distress_syndrome_mechanically_ventilated_in_prone_position]_ L2 - http://www.diseaseinfosearch.org/result/210 DB - PRIME DP - Unbound Medicine ER -