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Vaccination with BV8S2 protein amplifies TCR-specific regulation and protection against experimental autoimmune encephalomyelitis in TCR BV8S2 transgenic mice.
J Immunol 1998; 161(5):2178-86JI

Abstract

TCR determinants overexpressed by autopathogenic Th1 cells can naturally induce a second set of TCR-specific regulatory T cells. We addressed the question of whether immune regulation could be induced naturally in a genetically restricted model in which a major portion of TCR-specific regulatory T cells expressed the same target TCR BV8S2 chain as the pathogenic T cells specific for myelin basic protein (MBP). We found vigorous T cell responses to BV8S2 determinants in naive mice that could be further potentiated by vaccination with heterologous BV8S2 proteins, resulting in the selective inhibition of MBP-specific Th1 cells and protection against experimental encephalomyelitis. Moreover, coculture with BV8S2-specific T cells or their supernatants reduced proliferation, IFN-gamma secretion, and encephalitogenic activity of MBP-specific T cells. These results suggest that immune regulation occurs through a nondeletional cytokine-driven suppressive mechanism.

Authors+Show Affiliations

Portland Veterans Affairs Medical Center, Department of Neurology, Oregon Health Sciences University 97201, USA. offner.halina@portland.va.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9725209

Citation

Offner, H, et al. "Vaccination With BV8S2 Protein Amplifies TCR-specific Regulation and Protection Against Experimental Autoimmune Encephalomyelitis in TCR BV8S2 Transgenic Mice." Journal of Immunology (Baltimore, Md. : 1950), vol. 161, no. 5, 1998, pp. 2178-86.
Offner H, Adlard K, Bebo BF, et al. Vaccination with BV8S2 protein amplifies TCR-specific regulation and protection against experimental autoimmune encephalomyelitis in TCR BV8S2 transgenic mice. J Immunol. 1998;161(5):2178-86.
Offner, H., Adlard, K., Bebo, B. F., Schuster, J., Burrows, G. G., Buenafe, A. C., & Vandenbark, A. A. (1998). Vaccination with BV8S2 protein amplifies TCR-specific regulation and protection against experimental autoimmune encephalomyelitis in TCR BV8S2 transgenic mice. Journal of Immunology (Baltimore, Md. : 1950), 161(5), pp. 2178-86.
Offner H, et al. Vaccination With BV8S2 Protein Amplifies TCR-specific Regulation and Protection Against Experimental Autoimmune Encephalomyelitis in TCR BV8S2 Transgenic Mice. J Immunol. 1998 Sep 1;161(5):2178-86. PubMed PMID: 9725209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vaccination with BV8S2 protein amplifies TCR-specific regulation and protection against experimental autoimmune encephalomyelitis in TCR BV8S2 transgenic mice. AU - Offner,H, AU - Adlard,K, AU - Bebo,B F,Jr AU - Schuster,J, AU - Burrows,G G, AU - Buenafe,A C, AU - Vandenbark,A A, PY - 1998/9/2/pubmed PY - 2001/3/28/medline PY - 1998/9/2/entrez SP - 2178 EP - 86 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J. Immunol. VL - 161 IS - 5 N2 - TCR determinants overexpressed by autopathogenic Th1 cells can naturally induce a second set of TCR-specific regulatory T cells. We addressed the question of whether immune regulation could be induced naturally in a genetically restricted model in which a major portion of TCR-specific regulatory T cells expressed the same target TCR BV8S2 chain as the pathogenic T cells specific for myelin basic protein (MBP). We found vigorous T cell responses to BV8S2 determinants in naive mice that could be further potentiated by vaccination with heterologous BV8S2 proteins, resulting in the selective inhibition of MBP-specific Th1 cells and protection against experimental encephalomyelitis. Moreover, coculture with BV8S2-specific T cells or their supernatants reduced proliferation, IFN-gamma secretion, and encephalitogenic activity of MBP-specific T cells. These results suggest that immune regulation occurs through a nondeletional cytokine-driven suppressive mechanism. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/9725209/Vaccination_with_BV8S2_protein_amplifies_TCR_specific_regulation_and_protection_against_experimental_autoimmune_encephalomyelitis_in_TCR_BV8S2_transgenic_mice_ L2 - http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=9725209 DB - PRIME DP - Unbound Medicine ER -