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Cardiopulmonary bypass with danaparoid sodium and ancrod in heparin-induced thrombocytopenia.
Ann Thorac Surg 1998; 66(2):567-9AT

Abstract

Heparin is the standard anticoagulant for patients undergoing cardiopulmonary bypass. There are some patients for whom heparin is unsuitable and ancrod (a defibrinogenating enzyme) has been used as an alternative. We present a patient with heparin-induced thrombocytopenia in whom treatment ancrod was ineffective. The addition of danaparoid sodium (a heparinoid) allowed safe cardiopulmonary bypass. We discuss the reasons for this and suggest that the combination of ancrod and danaparoid sodium is a logical one in such cases.

Authors+Show Affiliations

Department of Cardiothoracic Surgery, St George's Hospital, London, England. rkanaga@sghms.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

9725413

Citation

Kanagasabay, R R., et al. "Cardiopulmonary Bypass With Danaparoid Sodium and Ancrod in Heparin-induced Thrombocytopenia." The Annals of Thoracic Surgery, vol. 66, no. 2, 1998, pp. 567-9.
Kanagasabay RR, Unsworth-White MJ, Robinson G, et al. Cardiopulmonary bypass with danaparoid sodium and ancrod in heparin-induced thrombocytopenia. Ann Thorac Surg. 1998;66(2):567-9.
Kanagasabay, R. R., Unsworth-White, M. J., Robinson, G., Bevan, D., Farnsworth, G., Haxby, E. J., & Smith, E. E. (1998). Cardiopulmonary bypass with danaparoid sodium and ancrod in heparin-induced thrombocytopenia. The Annals of Thoracic Surgery, 66(2), pp. 567-9.
Kanagasabay RR, et al. Cardiopulmonary Bypass With Danaparoid Sodium and Ancrod in Heparin-induced Thrombocytopenia. Ann Thorac Surg. 1998;66(2):567-9. PubMed PMID: 9725413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiopulmonary bypass with danaparoid sodium and ancrod in heparin-induced thrombocytopenia. AU - Kanagasabay,R R, AU - Unsworth-White,M J, AU - Robinson,G, AU - Bevan,D, AU - Farnsworth,G, AU - Haxby,E J, AU - Smith,E E, PY - 1998/9/2/pubmed PY - 1998/9/2/medline PY - 1998/9/2/entrez SP - 567 EP - 9 JF - The Annals of thoracic surgery JO - Ann. Thorac. Surg. VL - 66 IS - 2 N2 - Heparin is the standard anticoagulant for patients undergoing cardiopulmonary bypass. There are some patients for whom heparin is unsuitable and ancrod (a defibrinogenating enzyme) has been used as an alternative. We present a patient with heparin-induced thrombocytopenia in whom treatment ancrod was ineffective. The addition of danaparoid sodium (a heparinoid) allowed safe cardiopulmonary bypass. We discuss the reasons for this and suggest that the combination of ancrod and danaparoid sodium is a logical one in such cases. SN - 0003-4975 UR - https://www.unboundmedicine.com/medline/citation/9725413/Cardiopulmonary_bypass_with_danaparoid_sodium_and_ancrod_in_heparin_induced_thrombocytopenia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-4975(98)00511-6 DB - PRIME DP - Unbound Medicine ER -