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Blood and plasma selenium levels and GSH-Px activities in patients with arterial hypertension and chronic heart disease.
J Environ Pathol Toxicol Oncol. 1998; 17(3-4):285-9.JE

Abstract

The purpose of this study was to examine the relationship between arterial hypertension (HTN), chronic heart disease (CHD), and selenium (Se) status. Blood and plasma Se concentrations and Se-dependent GSH-Px activities were determined in 40 patients (HTN = 20; CHD = 20) and 17 healthy volunteers aged 41 to 66 years. Whole blood and plasma Se concentrations were significantly lower in the patients with HTN (19.1% and 26.3%, respectively) and CHD (33.1% and 29.4%, respectively) compared with the values obtained in the controls. The hypertensive patients had lower plasma Se-GSH-Px (26.7%), and those with CHD had both lower whole blood (19.5%) and plasma Se-GSH-Px activities (30.2%). A significant positive correlation between plasma Se-GSH-Px activity and ejection fraction (EF) was found in patients with CHD. There were significant correlations between plasma and whole blood Se concentration, plasma Se concentration and Se-GSH-Px activity, and whole blood Se and Se-GSH-Px activity. Our results showed that hypertensive patients and those with CHD had lower Se levels compared with controls. We conclude that low Se content might be a risk factor for development of HTN and CHD.

Authors+Show Affiliations

Department of Physiology, Faculty of Veterinary Medicine, Belgrade, Yugoslavia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9726804

Citation

Mihailović, M B., et al. "Blood and Plasma Selenium Levels and GSH-Px Activities in Patients With Arterial Hypertension and Chronic Heart Disease." Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer, vol. 17, no. 3-4, 1998, pp. 285-9.
Mihailović MB, Avramović DM, Jovanović IB, et al. Blood and plasma selenium levels and GSH-Px activities in patients with arterial hypertension and chronic heart disease. J Environ Pathol Toxicol Oncol. 1998;17(3-4):285-9.
Mihailović, M. B., Avramović, D. M., Jovanović, I. B., Pesut, O. J., Matić, D. P., & Stojanov, V. J. (1998). Blood and plasma selenium levels and GSH-Px activities in patients with arterial hypertension and chronic heart disease. Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer, 17(3-4), 285-9.
Mihailović MB, et al. Blood and Plasma Selenium Levels and GSH-Px Activities in Patients With Arterial Hypertension and Chronic Heart Disease. J Environ Pathol Toxicol Oncol. 1998;17(3-4):285-9. PubMed PMID: 9726804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blood and plasma selenium levels and GSH-Px activities in patients with arterial hypertension and chronic heart disease. AU - Mihailović,M B, AU - Avramović,D M, AU - Jovanović,I B, AU - Pesut,O J, AU - Matić,D P, AU - Stojanov,V J, PY - 1998/9/3/pubmed PY - 1998/9/3/medline PY - 1998/9/3/entrez SP - 285 EP - 9 JF - Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer JO - J Environ Pathol Toxicol Oncol VL - 17 IS - 3-4 N2 - The purpose of this study was to examine the relationship between arterial hypertension (HTN), chronic heart disease (CHD), and selenium (Se) status. Blood and plasma Se concentrations and Se-dependent GSH-Px activities were determined in 40 patients (HTN = 20; CHD = 20) and 17 healthy volunteers aged 41 to 66 years. Whole blood and plasma Se concentrations were significantly lower in the patients with HTN (19.1% and 26.3%, respectively) and CHD (33.1% and 29.4%, respectively) compared with the values obtained in the controls. The hypertensive patients had lower plasma Se-GSH-Px (26.7%), and those with CHD had both lower whole blood (19.5%) and plasma Se-GSH-Px activities (30.2%). A significant positive correlation between plasma Se-GSH-Px activity and ejection fraction (EF) was found in patients with CHD. There were significant correlations between plasma and whole blood Se concentration, plasma Se concentration and Se-GSH-Px activity, and whole blood Se and Se-GSH-Px activity. Our results showed that hypertensive patients and those with CHD had lower Se levels compared with controls. We conclude that low Se content might be a risk factor for development of HTN and CHD. SN - 0731-8898 UR - https://www.unboundmedicine.com/medline/citation/9726804/Blood_and_plasma_selenium_levels_and_GSH_Px_activities_in_patients_with_arterial_hypertension_and_chronic_heart_disease_ L2 - http://www.diseaseinfosearch.org/result/130 DB - PRIME DP - Unbound Medicine ER -