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Effect of selenium-enriched yeast pretreatment on the antioxidative defense in the skin of rats exposed to heat shock.
J Environ Pathol Toxicol Oncol. 1998; 17(3-4):305-11.JE

Abstract

Skin protection against heat shock and the specificity in the organization of antioxidative defenses were examined in rats given oral antioxidative pretreatment with selenium (Se)-enriched yeast and vitamins E, C, and A for 15 days and then exposed to hyperthermia. The activity of antioxidative enzymes in the skin and the liver was monitored 1 hour and 3 hours after heat shock. Glutathione peroxidase (GSH-Px) activity was increased in the skin after heat shock in the groups supplemented with antioxidants, but not in the controls. In contrast, the activity of liver GSH-Px was increased only in the controls receiving antioxidants. Heat shock led to a decrease in liver superoxide dismutase (SOD) activity at 1 hour in the antioxidant-supplemented group, but this was unchanged in the liver of all other groups and in the skin. The activity of thioredoxin reductase (TR) in the skin was increased in the antioxidant supplemented group 1 hour after heat shock, whereas the hepatic thioredoxin reductase activity was decreased. The activities of catalase (CAT), glutathione reductase (GR), and glutathione-S-transferase (GST) were unaffected by either treatment. These results suggest that supplementation with antioxidants protects the skin against heat shock, especially with respect to the GSH-Px and TR activity. The different response of the skin in comparison with the liver probably reflects differences in organization and regulation of antioxidative defenses.

Authors+Show Affiliations

Institute for Biological Research, Belgrade, Yugoslavia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9726807

Citation

Korać, B, et al. "Effect of Selenium-enriched Yeast Pretreatment On the Antioxidative Defense in the Skin of Rats Exposed to Heat Shock." Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer, vol. 17, no. 3-4, 1998, pp. 305-11.
Korać B, Buzadzić B, Saicić ZS, et al. Effect of selenium-enriched yeast pretreatment on the antioxidative defense in the skin of rats exposed to heat shock. J Environ Pathol Toxicol Oncol. 1998;17(3-4):305-11.
Korać, B., Buzadzić, B., Saicić, Z. S., Radojicić, R., & Petrović, V. M. (1998). Effect of selenium-enriched yeast pretreatment on the antioxidative defense in the skin of rats exposed to heat shock. Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer, 17(3-4), 305-11.
Korać B, et al. Effect of Selenium-enriched Yeast Pretreatment On the Antioxidative Defense in the Skin of Rats Exposed to Heat Shock. J Environ Pathol Toxicol Oncol. 1998;17(3-4):305-11. PubMed PMID: 9726807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of selenium-enriched yeast pretreatment on the antioxidative defense in the skin of rats exposed to heat shock. AU - Korać,B, AU - Buzadzić,B, AU - Saicić,Z S, AU - Radojicić,R, AU - Petrović,V M, PY - 1998/9/3/pubmed PY - 1998/9/3/medline PY - 1998/9/3/entrez SP - 305 EP - 11 JF - Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer JO - J. Environ. Pathol. Toxicol. Oncol. VL - 17 IS - 3-4 N2 - Skin protection against heat shock and the specificity in the organization of antioxidative defenses were examined in rats given oral antioxidative pretreatment with selenium (Se)-enriched yeast and vitamins E, C, and A for 15 days and then exposed to hyperthermia. The activity of antioxidative enzymes in the skin and the liver was monitored 1 hour and 3 hours after heat shock. Glutathione peroxidase (GSH-Px) activity was increased in the skin after heat shock in the groups supplemented with antioxidants, but not in the controls. In contrast, the activity of liver GSH-Px was increased only in the controls receiving antioxidants. Heat shock led to a decrease in liver superoxide dismutase (SOD) activity at 1 hour in the antioxidant-supplemented group, but this was unchanged in the liver of all other groups and in the skin. The activity of thioredoxin reductase (TR) in the skin was increased in the antioxidant supplemented group 1 hour after heat shock, whereas the hepatic thioredoxin reductase activity was decreased. The activities of catalase (CAT), glutathione reductase (GR), and glutathione-S-transferase (GST) were unaffected by either treatment. These results suggest that supplementation with antioxidants protects the skin against heat shock, especially with respect to the GSH-Px and TR activity. The different response of the skin in comparison with the liver probably reflects differences in organization and regulation of antioxidative defenses. SN - 0731-8898 UR - https://www.unboundmedicine.com/medline/citation/9726807/Effect_of_selenium_enriched_yeast_pretreatment_on_the_antioxidative_defense_in_the_skin_of_rats_exposed_to_heat_shock_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -